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Preparation method and analgesic application of bauhinia brachycarpa extract and extractant thereof

A technology of the saddle leaf beetle and its extract, which is applied to the preparation of the saddle leaf beetle extract and its extract, and the application field of analgesics, and can solve the problems such as the absence of the saddle leaf beetle extract

Inactive Publication Date: 2019-03-08
DALI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports on the preparation method of the extract of S. saddleleaf, the drug combination with the extract as the active ingredient, and its application in analgesia at home and abroad.

Method used

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  • Preparation method and analgesic application of bauhinia brachycarpa extract and extractant thereof
  • Preparation method and analgesic application of bauhinia brachycarpa extract and extractant thereof
  • Preparation method and analgesic application of bauhinia brachycarpa extract and extractant thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The preparation of the extract of the present invention and its extract:

[0018] Dry the above-ground part of S. saddleleaf plant (19.6 kg), crush it to 30 mesh, and extract it three times with 95% ethanol at room temperature, 100 L each time for 24 hours, combine the extracts, and concentrate the extracts under reduced pressure Obtain extract (2.4 kg). The obtained extract was suspended with 3.0 kg of water, and then distributed with 3 L of petroleum ether, ethyl acetate and n-butanol successively for 4 times; the extract of the corresponding parts and the remaining water phase were obtained.

Embodiment 2

[0020] The analgesic activity detection of the extract of the present invention and its extract:

[0021] An acetic acid writhing test was used to measure the analgesic activity of the extract of the present invention and the extract thereof. Kunming mice were half male and half female, weighing 18–22 g, fasted and watered 12 hours before the experiment, and randomly divided into control group, sample group, and positive drug group, with 8 mice in each group. Orally administered at a dose of 50–1000 mg / kg, the negative control group was given the same amount of normal saline, and the positive drug group was given aspirin. After 40 minutes of administration, each mouse was intraperitoneally injected with 0.6% glacial acetic acid solution 0.2 mL / 10g After injecting glacial acetic acid for 3-5 minutes, observe and record the number of writhing in mice within 15 minutes, and calculate the inhibitory rate of the test substance on the mice's acetic acid writhing according to the fol...

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Abstract

The invention relates to a preparation method and analgesic application of a bauhinia brachycarpa extract and an extractant thereof and belongs to the pharmaceutical field of traditional Chinese medicines and natural drugs. The invention relates to analgesic drugs taking the bauhinia brachycarpa extract and extractant thereof as active ingredients. According to the invention, the indication of bauhinia brachycarpa medicinal materials is expanded and the medicinal value of traditional bauhinia brachycarpa medicinal materials is increased.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and natural medicine pharmacy, in particular, it relates to a preparation method of the extract and the extract thereof, a drug combination using the extract and the extract as the active ingredient, and an analgesic Applications. Background technique [0002] Saddle leaf sheep's hooves ( Bauhinia brachycarpa Wall.) is also known as saddle leaf sheep's hoof beetle, night close door, saddle leaf, big fly, butterfly wind, sheep's foot vine, night leaf, chaimizi, etc., which is a perennial erect or climbing small shrub of the genus Fabaceae. It is produced in Sichuan, Yunnan, Gansu, Hubei and other places. Born in mountain grass slopes and shrubs beside rivers and streams at an altitude of 800-2200 meters. "Zhonghua Materia Medica" and other Chinese medicine classics record that the branches, leaves or roots of this plant have medicinal properties, and have the effects of dispelling da...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61P29/00
CPCA61K36/48A61K2236/33A61K2236/35A61K2236/39A61K2236/51A61P29/00
Inventor 姜北肖朝江单华董相沈怡刘健雷婷刘晓波
Owner DALI UNIV