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Preparation method of polyurethane and sericin medical composite film with water absorption and moisture permeability

A technology of sericin and composite film, which is applied in the direction of absorbent pads, medical science, bandages, etc., can solve the problems of waste of resources, environmental pollution, loss, etc., and achieve the effect of being difficult to control, expanding the scope of use, and easy to swell

Inactive Publication Date: 2011-12-28
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sericin is a colloidal protein wrapped around silk fibroin in silk, accounting for 20-30% of silk components. Based on the current production technology in my country, 150-250 Kg of sericin will be produced with wastewater for every 1 ton of silkworm cocoons processed. loss, not only causing environmental pollution, but also a great waste of resources

Method used

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  • Preparation method of polyurethane and sericin medical composite film with water absorption and moisture permeability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Preparation of polyurethane solution: Mix 9 g of aliphatic polyurethane with 16.7 g of N,N-dimethylformamide solvent, and keep stirring in a water bath at 40 °C until completely dissolved to obtain a polyurethane solution with a concentration of 35%.

[0023] (2) Preparation of sericin suspension: Disperse 1 g of sericin particles in 6.6 g of N,N-dimethylformamide solvent and stir for a period of time to obtain a uniformly dispersed sericin suspension;

[0024] (3) Configuration of polyurethane / sericin blend solution: Add the sericin suspension obtained in (2) above into the polyurethane solution in (1) above, and stir at high speed for 30 minutes to obtain a uniformly mixed film-making solution, in which sericin Protein content is 3 wt%;

[0025] (4) Dry film formation: Pour a certain volume of film-forming solution onto the glassine paper, control a certain force and speed with a smear stick, coat the film evenly, and then put it in an oven at 70 °C for 5 minutes ...

Embodiment 2

[0027] (1) Preparation of polyurethane solution: Mix 7 g of medical polyurethane with 10.5 g of N,N-dimethylformamide solvent, and keep stirring in a water bath at 50 °C until completely dissolved to obtain a polyurethane solution with a concentration of 40%;

[0028] (2) Preparation of sericin suspension: Disperse 3 g of sericin particles in 12.8 g of N,N-dimethylformamide solvent and stir for a period of time to obtain a uniformly dispersed sericin suspension;

[0029] (3) Configuration of polyurethane / sericin blend solution: Add the sericin suspension obtained in (2) above into the polyurethane solution in (1) above, and stir at high speed for 30 minutes to obtain a uniformly mixed film-making solution, in which sericin The protein content is 9 wt%;

[0030] (4) Dry film formation: Pour a certain volume of film-forming solution onto the glassine paper, control a certain force and speed with a smear stick, coat the film evenly, and then put it in an oven at 30 °C for 30 minu...

Embodiment 3

[0032] (1) Preparation of polyurethane solution: Mix 5 g of medical polyurethane with 6.1 g of N,N-dimethylformamide solvent, and keep stirring in a water bath at 60 °C until completely dissolved to obtain a polyurethane solution with a concentration of 45%;

[0033] (2) Preparation of sericin suspension: Disperse 5 g of sericin particles in 17.2 g of N,N-dimethylformamide solvent and stir for a period of time to obtain a uniformly dispersed sericin suspension;

[0034] (3) Configuration of polyurethane / sericin blend solution: Add the sericin suspension obtained in (2) above into the polyurethane solution in (1) above, and stir at high speed for 30 minutes to obtain a uniformly mixed film-making solution, in which sericin The protein content is 15 wt%;

[0035] (4) Wet film formation: Pour a certain volume of film-making liquid onto glassine paper, control a certain force and speed with a smear stick, coat the film evenly, and then immerse in a certain volume of clear water to...

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Abstract

The invention discloses a preparation method of a polyurethane and sericin medical composite film with water absorption and moisture permeability. The steps are as follows: (1) preparation of polyurethane solution; (2) preparation of sericin suspension; (3) configuration of aliphatic polyurethane and sericin blend solution; (4) pouring membrane-forming liquid into glassine On the paper, the smear stick is evenly applied, and two methods of dry film formation and wet film formation are used to make a uniform film. Using sericin as the filling material, introducing sericin particles into the matrix not only forms micropores around the sericin particles, but also sericin contains a variety of amino acids with polar groups, and its good hydrophilicity provides a bridge for water transfer , so that the prepared film has good water absorption and moisture permeability. Bioactive ingredients can be loaded during the preparation process, and the bioactive ingredients can include various antibacterial, hemostatic, anti-inflammatory, analgesic drugs and / or growth factors and other active ingredients required for treatment to promote wound healing.

Description

technical field [0001] The invention relates to a preparation method of a medical composite film, in particular to a preparation method of a polyurethane and sericin medical composite film with water absorption and moisture permeability. Background technique [0002] Polyurethane (PU) is a polymer material formed by addition polymerization of organic diisocyanate or polyisocyanate and dihydroxyl or polyhydroxyl compounds. Because of its excellent physical and mechanical properties, good tissue and blood compatibility, low toxicity, etc., It has been widely used in the field of biomedicine and is considered to be one of the most valuable medical synthetic polymer materials. The excellent elasticity and toughness of polyurethane film materials, good waterproof and moisture permeability, and drug resistance make it widely used in medical dressings such as semi-permeable medical dressings, surgical towels, postoperative dressings, and wound dressing materials. [0003] The func...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/26A61L15/42
Inventor 姚菊明胡丹丹刘琳章伟华
Owner ZHEJIANG SCI-TECH UNIV
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