A bone repair scaffold for bone tuberculosis treatment and its preparation method
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A technology for bone repair and bone tuberculosis, applied in the field of biomedical engineering, can solve the problems of low systemic drug delivery efficiency, single drug loading, long time, etc., and achieve good osteoinductive ability and bone conduction ability, good biocompatibility , the effect of good mechanical properties
Active Publication Date: 2021-06-01
GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
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Problems solved by technology
However, this treatment method mainly has two problems: (1) the postoperative systemic drug administration efficiency is too low and the time is too long, generally at least 6 to 9 months of multi-drug combination chemotherapy
Because the bone tissue infected with Mycobacterium tuberculosis is at the end of the blood circulation and there are a large number of bacterial thrombi, the blood supply is poor, and the efficiency of systemic administration is low. Long-term medication not only accelerates the bacterial resistance, but also increases the toxic side effects on the patient's liver and kidneys.
(2) Debridement of the lesion can easily lead to local bone defects, which need to be repaired and reconstructed. However, the characteristics of Mycobacterium tuberculosis that are difficult to eradicate lead to an inflammatory environment in the local area of the lesion, which is extremely unfavorable for the formation of new bone
[0004] The existing drug-loaded anti-tuberculosis bone repair scaffolds generally have the disadvantages of single drug loading, fast drug release, unsatisfactory mechanical properties of the scaffold, and poor degradation performance and osteogenesis ability.
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Embodiment 1
[0043] A bone repair bracket for treating bone tuberculosis, comprising the following materials in parts by weight: 20 parts of strontium-doped nano-hydroxyapatite, 40 parts of gelatin, and 10 parts of sodium alginate drug-loaded microspheres.
[0044] The preparation method of the bone repair bracket of this embodiment is:
[0045] (1) Preparation of strontium-doped nano-hydroxyapatite scaffolds
[0046] Weigh calcium nitrate tetrahydrate and put it in a beaker, add deionized water to dissolve it, the solution A with a concentration of 2mol / L is used for later use; weigh strontium nitrate and put it in a beaker, add deionized water to dissolve it, and make a solution with a concentration of 2mol / L B, for standby; Weigh diammonium hydrogen phosphate and place it in a beaker, add deionized water to dissolve, the concentration is solution C of 2mol / L, and set aside;
[0047] Add an equal volume of liquid B to liquid A, add NH 3 ·H 2 O adjusts the pH to 11, and adds sodium lau...
Embodiment 2
[0059] A bone repair bracket for treating bone tuberculosis, comprising the following materials in parts by weight: 45 parts of strontium-doped nano-hydroxyapatite, 50 parts of gelatin, and 5 parts of sodium alginate drug-loaded microspheres.
[0060] The preparation method of the bone repair scaffold in this example is the same as that in Example 1.
Embodiment 3
[0062] A bone repair bracket for treating bone tuberculosis, comprising the following materials in parts by weight: 45 parts of strontium-doped nano-hydroxyapatite, 45 parts of gelatin, and 10 parts of sodium alginate drug-loaded microspheres.
[0063] The preparation method of the bone repair scaffold in this example is the same as that in Example 1.
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Abstract
The invention relates to a bone repair bracket for bone tuberculosis treatment and a preparation method thereof, belonging to the technical field of biomedical engineering. The bone repair scaffold of the invention comprises strontium-doped nano-hydroxyapatite, gelatin and sodium alginate drug-loaded microspheres. The bone repair scaffold of the present invention has an anti-tuberculosis drug slow-release system with a three-dimensional porous scaffold structure, which is more conducive to the growth of cells and blood vessels than other implants, promotes new bone regeneration, and can be localized in tuberculosis lesions for a long time. Effectively release anti-tuberculosis drugs and provide a good local environment for the healing of bone defects; the drug-loaded anti-bone tuberculosis bone repair scaffold of the present invention has good mechanical properties and biocompatibility, can continuously release anti-tuberculosis drugs, and has good Osteoinductive ability and osteoconductive ability can induce the regeneration of bone tissue defects.
Description
technical field [0001] The invention relates to a bone repair bracket for bone tuberculosis treatment and a preparation method thereof, belonging to the technical field of biomedical engineering. Background technique [0002] The incidence of bone and joint tuberculosis accounts for about 3 to 5% of the total incidence of tuberculosis, and is the highest incidence of extrapulmonary tuberculosis. 90% of them invade the load-bearing parts such as vertebral body, knee joint and hip joint. In the infection focus, Mycobacterium tuberculosis causes hypersensitivity reactions through pathogenic components such as lipids, proteins, and polysaccharides, leading to local bone destruction and sequestrum formation. In the late stage of the disease, as the bacterial infection spreads, the bone mass is severely lost, leading to chronic tuberculous osteomyelitis, pathological fractures and paralysis, and the disability rate is extremely high. [0003] At present, the mainstream method fo...
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