A bone repair scaffold for bone tuberculosis treatment and its preparation method

Abstract

The invention relates to a bone repair bracket for bone tuberculosis treatment and a preparation method thereof, belonging to the technical field of biomedical engineering. The bone repair scaffold of the invention comprises strontium-doped nano-hydroxyapatite, gelatin and sodium alginate drug-loaded microspheres. The bone repair scaffold of the present invention has an anti-tuberculosis drug slow-release system with a three-dimensional porous scaffold structure, which is more conducive to the growth of cells and blood vessels than other implants, promotes new bone regeneration, and can be localized in tuberculosis lesions for a long time. Effectively release anti-tuberculosis drugs and provide a good local environment for the healing of bone defects; the drug-loaded anti-bone tuberculosis bone repair scaffold of the present invention has good mechanical properties and biocompatibility, can continuously release anti-tuberculosis drugs, and has good Osteoinductive ability and osteoconductive ability can induce the regeneration of bone tissue defects.

Description

technical field [0001] The invention relates to a bone repair bracket for bone tuberculosis treatment and a preparation method thereof, belonging to the technical field of biomedical engineering. Background technique [0002] The incidence of bone and joint tuberculosis accounts for about 3 to 5% of the total incidence of tuberculosis, and is the highest incidence of extrapulmonary tuberculosis. 90% of them invade the load-bearing parts such as vertebral body, knee joint and hip joint. In the infection focus, Mycobacterium tuberculosis causes hypersensitivity reactions through pathogenic components such as lipids, proteins, and polysaccharides, leading to local bone destruction and sequestrum formation. In the late stage of the disease, as the bacterial infection spreads, the bone mass is severely lost, leading to chronic tuberculous osteomyelitis, pathological fractures and paralysis, and the disability rate is extremely high. [0003] At present, the mainstream method fo...

AI Technical Summary

Problems solved by technology

However, this treatment method mainly has two problems: (1) the postoperative systemic drug administration efficiency is too low and the time is too long, generally at least 6 to 9 months of multi-drug combination chemotherapy

Because the bone tissue infected with Mycobacterium tuberculosis is at the end of the blood circulation and there are a large number of bacterial thrombi, the blood supply is poor, and the efficiency of systemic administration is low. Long-term medication not only accelerates the bacterial resistance, but also increases the toxic side effects on the patient's liver and kidneys.

(2) Debridement of the lesion can easily lead to local bone defects, which need to be repaired and reconstructed. However, the characteristics of Mycobacterium tuberculosis that are difficult to eradicate lead to an inflammatory environment in the local area of ​​the lesion, which is extremely unfavorable for the formation of new bone

[0004] The existing drug-loaded anti-tuberculosis bone repair scaffolds generally have the disadvantages of single drug loading, fast drug release, unsatisfactory mechanical properties of the scaffold, and poor degradation performance and osteogenesis ability.

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