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Granulation method applicable to viscous materials

A material and viscous technology, which is applied in the field of granulation of viscous materials, can solve the problems of high sugar content, high viscosity and long time consumption of materials, and achieve the effect of uniform granulation, reducing granulation cycle and improving granulation efficiency

Inactive Publication Date: 2019-03-15
BEIJING GOLDENTEAM TECH
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  • Description
  • Claims
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Problems solved by technology

[0006] The purpose of the present invention is to propose a granulation method suitable for viscous materials, which can well solve the problems of easy collapse of the pot and long time consumption caused by the high sugar content and high viscosity of the material. high particle efficiency

Method used

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  • Granulation method applicable to viscous materials

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Embodiment 1

[0032] Prepare 160kg of a certain granule, according to the formula requirements, take by weighing 44.5kg of extract, 5.6kg of amber powder, 23.7kg of dextrin, 23.8kg of β-cyclodextrin, and 62.4kg of sucrose powder. First add amber powder, dextrin, β-cyclodextrin, and sucrose powder to the material pot of the wet granulator, dry mix for 3 minutes, add extract, and granulate for 2 minutes. Make preliminary granules, then dry and pulverize to make 160kg of backfill powder.

[0033] Backfill powder 40kg, weigh again extract 33.4kg, amber powder 4.2kg, dextrin 17.8kg, β-cyclodextrin 17.8kg, sucrose powder 46.8kg, amber powder, dextrin, β-cyclodextrin, sucrose powder 1. Add the backfill powder to the material pot of the wet granulator, dry mix for 3 minutes, add the extract, and granulate for 2 minutes to produce 160kg of the granule. The particle size of the prepared granule is uniform and there is no phenomenon of stepping on the pot.

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Abstract

The invention discloses a granulation method applicable to viscous materials. Materials in a formula are divided into viscous materials and non-viscous materials according to the granulation method, and the method comprises the following steps: firstly, part of the viscous materials and part of the non-viscous materials are mixed for first granulation, and backfill powder is obtained after dryingand smashing; then the viscous materials, the non-viscous materials and the backfill powder are weighed on the basis of second adding quantities and mixed for second granulation, and a to-be-granulated product is obtained. In the granulation process, collapse of the viscous materials in the granulation process can be prevented by adding the backfill powder, and prepared particles are uniform; by means of two times of granulation, material mixing efficiency can be increased, granulation period of the viscous materials can be shortened, and granulation efficiency can be increased. Besides, the backfill powder is prepared in advance, so that the adding quantities of the backfill powder, the viscous materials and the non-viscous materials can be adjusted flexibly according to yield requirementof the to-be-granulated product, the granulation efficiency is further increased, and the process is good in flexibility and suitable for large-scale production of the to-be-granulated product.

Description

[0001] The present invention is a divisional application with the application number 201710183219.3, the application date is March 24, 2017, and the invention name is "a granulation method suitable for viscous materials". technical field [0002] The invention relates to the technical field of granulation methods, in particular to a granulation method suitable for viscous materials. Background technique [0003] The technical background related to the present invention will be described below, but these descriptions do not necessarily constitute the prior art of the present invention. [0004] At present, in the pharmaceutical industry, there are many granulation methods, but wet granulation is mainly used. The granules produced by the wet granulation process are mainly used for granules or tabletting; the characteristics of wet granulation are that the granulation time is short, the granules are irregular, and they need to be dried. In the pharmaceutical industry, some mat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/40
CPCA61K9/1611A61K9/1623A61K9/1652A61K9/1682A61K9/1694
Inventor 邵天君
Owner BEIJING GOLDENTEAM TECH
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