Composition for facilitating cerebral injury neural restoration as well as application and evaluation method thereof

A nerve repair and brain injury technology, applied in the field of neural stem cells, can solve problems such as deterioration of the microenvironment, less differentiation of neuron cells, and unsatisfactory repair effects, and achieve the effects of promoting differentiation, promoting recovery, and improving the damaged microenvironment

Inactive Publication Date: 2019-03-22
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The great challenge facing neural stem cell transplantation is that the microenvironment deteriorates after central nervous system injury, and the neural stem cells transplanted into the lesion focus more on astrocytes and oligodendrocytes, and more on neuron cells. Less, leading to unsatisfactory repair effect

Method used

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  • Composition for facilitating cerebral injury neural restoration as well as application and evaluation method thereof
  • Composition for facilitating cerebral injury neural restoration as well as application and evaluation method thereof
  • Composition for facilitating cerebral injury neural restoration as well as application and evaluation method thereof

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Embodiment Construction

[0024] Drugs with microtubule stabilizing effects, such as the anticancer drug paclitaxel, can promote microtubule stability, prevent the formation of axon shrinkage vesicles, and promote nerve regeneration. However, there is no report on the combination of microtubule stabilizing drugs and neural stem cell compositions for the treatment of brain injury nerve repair.

[0025] In view of the deficiencies in the prior art, the inventors of this case have been able to propose the technical solution of the present invention after long-term research and extensive practice, which mainly involves a composition comprising microtubule stabilizing drugs and neural stem cells. The technical solution, its implementation process and principle will be further explained as follows.

[0026] One aspect of the embodiments of the present invention provides the application of the composition for promoting brain injury nerve repair in the preparation of products for repairing brain injury.

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Abstract

The invention discloses a composition for facilitating cerebral injury neural restoration as well as application and an evaluation method thereof. The composition for facilitating cerebral injury neural restoration is prepared from a microtube stabilizing medicament and neural stem cells. The invention further discloses application of the composition to preparation of a product for restoring cerebral injury. The product at least has the functions of relieving the restraining effect of myelin protein molecules after cerebral injury, facilitating the differentiation of nervous stem cells to neuronal cells, and facilitating the growth of axons to realize cerebral injury restoration finally. The composition for facilitating cerebral injury neural restoration provided by the invention can relieve the restraining environment of the myelin protein molecules after cerebral injury, relieve a damage microenvironment through a microtube stabilizing medicament, facilitate the differentiation of the nervous stem cells to the neuronal cells, and facilitate the growth of the axons to finally facilitate the restoration of cerebral injury.

Description

technical field [0001] The invention specifically relates to a composition for promoting nerve repair of brain injury, in particular to a composition for promoting nerve repair of craniocerebral injury, its application in brain injury repair and its evaluation method, belonging to the technical field of neural stem cells. Background technique [0002] Brain injury such as traumatic craniocerebral injury is a common disabling disease in clinical practice, but there is no effective treatment to improve the neurological dysfunction of brain injury. [0003] Stem cell replacement therapy for craniocerebral injury has attracted everyone's attention. Among them, neural stem cells are derived from neural tissue and can differentiate into neurons, astrocytes and oligodendrocytes. The great challenge facing neural stem cell transplantation is that the microenvironment deteriorates after central nervous system injury, and the neural stem cells transplanted into the lesion focus more ...

Claims

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Application Information

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IPC IPC(8): A61K35/30G01N1/36G01N33/15A61P25/28A61P25/00A61K31/337
CPCA61K31/337A61K35/30G01N1/36G01N33/15G01N2001/366A61K2300/00
Inventor戴建武李晓然
OwnerSUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI