Nano-silver toner and preparation method thereof

A technology of nano-silver and lotion, which is applied in the field of nano-silver lotion and its preparation, can solve the problems of silver nano-particle agglomeration, restriction, and poor water solubility of curcumin, etc., and achieve the effects of strengthening sterilization and antibacterial, mild performance, and reducing inflammation. Effect

Inactive Publication Date: 2019-03-26
广州菩萃堂医药研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the problems of easy agglomeration of silver nanoparticles and poor water solubility of curcumin, it is limited in practical application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A nano-silver lotion made from the following raw materials by weight: 0.1 part of silver nitrate, 0.3 part of ascorbic acid, 0.3 part of beta-cyclodextrin, 0.1 part of curcumin, 6 parts of cetyl alcohol, 0.2 part of lanolin, horn 0.2 parts of squalane, 0.8 parts of triethanolamine, 10 parts of glycerol, 110 parts of deionized water, and 0.8 parts of laminarin.

[0022] A preparation method of nano silver lotion, comprising the following steps:

[0023] (1) silver nitrate, ascorbic acid, curcumin are added water respectively and are configured into the silver nitrate aqueous solution that concentration is 0.5g / L, the ascorbic acid aqueous solution that concentration is 0.5g / L, the curcumin aqueous solution that molar concentration is 2mmol / L; Ascorbic acid aqueous solution Add it to the silver nitrate aqueous solution, stir for 3 hours, add β-cyclodextrin and curcumin aqueous solution, continue to stir for 7 hours, and then perform dialysis to remove unreacted silver nit...

Embodiment 2

[0028] A nano-silver lotion made from the following raw materials by weight: 0.05 parts of silver nitrate, 0.2 parts of ascorbic acid, 0.2 parts of β-cyclodextrin, 0.05 parts of curcumin, 5 parts of cetyl alcohol, 0.1 part of lanolin, horn 0.1 part of squalane, 0.5 part of triethanolamine, 7 parts of glycerol, 100 parts of deionized water, 0.6 part of Enteromorpha polysaccharide.

[0029] A preparation method of nano silver lotion, comprising the following steps:

[0030] (1) silver nitrate, ascorbic acid, curcumin are added water respectively and are configured into the silver nitrate aqueous solution that concentration is 0.4g / L, the ascorbic acid aqueous solution that concentration is 0.4g / L, the curcumin aqueous solution that molar concentration is 1mmol / L; Ascorbic acid aqueous solution Added in the silver nitrate aqueous solution, stirred for 1 hour and then added beta-cyclodextrin and curcumin aqueous solution, continued to stir for 5 hours and then dialyzed to remove u...

Embodiment 3

[0035] A nano-silver lotion made from the following raw materials by weight: 0.08 parts of silver nitrate, 0.2 parts of ascorbic acid, 0.3 parts of beta-cyclodextrin, 0.08 parts of curcumin, 6 parts of cetyl alcohol, 0.2 parts of lanolin, horn 0.2 parts of squalane, 0.7 parts of triethanolamine, 8 parts of glycerol, 105 parts of deionized water, and 0.7 parts of Enteromorpha polysaccharide.

[0036] A preparation method of nano silver lotion, comprising the following steps:

[0037] (1) silver nitrate, ascorbic acid, curcumin are added water respectively and are configured into the silver nitrate aqueous solution that concentration is 0.5g / L, the ascorbic acid aqueous solution that concentration is 0.5g / L, the curcumin aqueous solution that molar concentration is 2mmol / L; Ascorbic acid aqueous solution Add it into the silver nitrate aqueous solution, stir for 2 hours, add β-cyclodextrin and curcumin aqueous solution, continue to stir for 6 hours, and then perform dialysis to r...

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PUM

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Abstract

The invention discloses nano-silver toner and a preparation method thereof. The nano-silver toner is prepared from the following raw materials in parts by weight: 0.05-0.1 part of silver nitrate, 0.2-0.3 part of ascorbic acid, 0.2-0.3 part of beta-cyclodextrin, 0.05-0.1 part of curcumin, 5-6 parts of hexadecanol, 0.1-0.2 part of lanolin, 0.1-0.2 part of squalane, 0.5-0.8 part of triethanolamine, 7-10 parts of glycerol, 100-110 parts of deionized water and 0.6-0.8 part of algae polysaccharide. Nano-silver and the curcumin which are added in the formula of the nano-silver toner achieve a mutually synergistic effect, the bactericidal and bacteriostatic effects of the nano-silver toner are enhanced, acnes can be treated and prevented, the inflammation reaction is alleviated, the skin barrier function is recovered, performance is mild, irritation to the skin is avoided, in addition, the beta-cyclodextrin is adopted to load the nano-silver and the curcumin, a stable nano-sol system is formedin an aqueous solution, the problem that the nano silver are likely to be agglomerated and the water solubility of the curcumin is poor are solved, and the stability of the toner is improved.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a nano silver lotion and a preparation method thereof. Background technique [0002] In daily life, due to various reasons such as the exposure of the facial skin to the ultraviolet rays of the sun, the pollution of corrosive substances in the air, and careless cleaning, etc., the facial skin often loses moisture, luster and elasticity, becomes rough, deposits pigment, and even produces acne , Seriously affect the appearance and beauty of the face. However, the existing products for treating acne often use ingredients such as hormones, antibiotics, retinoic acid, and fruit acids, which are highly irritating and prone to drug resistance. [0003] Silver nanoparticles are considered as one of the best antimicrobial agents due to their broad-spectrum antibacterial activity and limited bacterial resistance. Silver nanoparticles can increase the permeability of cell membranes, whi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/73A61K8/67A61K8/35A61K8/34A61K8/31A61K8/19A61P17/10A61Q19/00
CPCA61P17/10A61Q19/00A61K8/19A61K8/31A61K8/342A61K8/35A61K8/676A61K8/73A61K8/738A61K8/925
Inventor 张凤娟
Owner 广州菩萃堂医药研发有限公司
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