Aqueous formulation
A water-based preparation, selected technology, applied in directions such as non-central analgesics, anti-inflammatory agents, aerosol delivery, etc., can solve problems such as the disclosure and enlightenment of solutions without anti-inflammatory sprays, and achieve a good feeling of taking, The effect of ensuring the circulation process and sufficient stability
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Embodiment 1
[0069] Dissolve 0.2 g of sodium azulene sulfonate in purified water, and dilute to 100 mL. 5 mL of this liquid was put into a volumetric flask, and 15 g of various sugar alcohols were further added as additives, shaken well, and then the volume was adjusted to 50 mL with purified water. This liquid was subdivided into three sample bottles of about 15 cc each, and used as a test liquid. Then, the absorbance of the prepared test solution was measured, and then stored at 60°C for 7 days to measure the absorbance, and the residual rate was calculated based on the decrease in absorbance at the start and after the accelerated test.
[0070] The results are shown in Table 1.
[0071] Table 1
[0072] (w / v%)
[0073]
[0074] From the results in Table 1, it is clear that the stability of sodium azulene sulfonate is significantly deteriorated when sugar alcohol is blended into sodium azulene sulfonate.
Embodiment 2
[0076] Dissolve 0.2 g of sodium azulene sulfonate in purified water, and dilute to 100 mL. After adding 5 mL of this liquid to a volumetric flask, a predetermined amount of maltitol was added and shaken well, and then the volume was adjusted to 50 mL with purified water. This liquid was subdivided into three sample bottles of about 15 cc each, and used as a test liquid. Then, the absorbance of the prepared test solution was measured, and then stored at 60°C for 7 days to measure the absorbance, and the residual rate was calculated based on the decrease in absorbance at the start and after the accelerated test. The results are shown in Table 2.
[0077] Table 2
[0078] (w / v%)
[0079] Example example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Example 10 Example 11 Example 12 Example 13 Sodium azulene sulfonate 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Malt...
Embodiment 3
[0082] Dissolve 0.2 g of sodium azulene sulfonate in purified water, and dilute to 100 mL. 5 mL of this liquid was put into a volumetric flask, and a predetermined amount of specified additives (glycerin and alcohol (ethanol)) was added and shaken well, then purified water was added, and the volume was adjusted to about 80% of 50 mL. Then, a pH regulator was added to adjust the pH to a range of 7.0±0.5, and then the volume was adjusted to 50 mL. This liquid was subdivided into 3 sample bottles of about 15 ㏄ each and used as a test liquid. Then, the absorbance of the prepared test solution was measured, and then stored at 60°C for 7 days to measure the absorbance, and the residual rate was calculated based on the decrease in absorbance at the beginning and after completion of the severe test. The results are shown in Table 3.
[0083] table 3
[0084] (w / v%)
[0085]
[0086] From the results of Table 1 and Table 3, it is clear that adding glycerin or ethanol to sodium a...
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