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A magnetic size-dependent microfluidic chip

A microfluidic chip and size technology, applied in laboratory containers, laboratory utensils, chemical instruments and methods, etc., can solve the problems of inability to ensure accurate separation of magnetic microspheres, difficult channel processing, and inaccurate separation. , to achieve the effect of reducing manual contact, less reagent consumption and simple operation

Active Publication Date: 2021-09-07
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the channel processing of this microfluidic chip is difficult and the detection method is complicated. Using a magnetic field to separate the magnetic microspheres cannot guarantee the accurate separation of magnetic microspheres with similar quality, or the magnetic microspheres of the same marker have the same quality, and the magnetic field force have the same effect, and cannot be separated accurately

Method used

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  • A magnetic size-dependent microfluidic chip
  • A magnetic size-dependent microfluidic chip
  • A magnetic size-dependent microfluidic chip

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Embodiment Construction

[0022] The present invention will be described in detail below in conjunction with the accompanying drawings.

[0023] The schematic diagram of the structure of the magnetic size-dependent microfluidic chip provided by the present invention is as follows: figure 1 with figure 2 As shown, it includes a cover sheet 1 and a base sheet 2, the cover sheet 1 is located directly above the base sheet 2, and the cover sheet 1 and the base sheet 2 are hermetically connected.

[0024] Such as figure 2 As shown, a magnetophoretic separation structure is provided on the lower surface of the cover sheet 1 , and the magnetophoretic separation structure includes a buffer moving channel 3 , a sample moving channel 4 , a confluence channel 5 , a capture channel 6 and a waste liquid discharge channel 7 . In this embodiment, the buffer moving channel, the sample moving channel, the merging channel, the capturing channel and the waste liquid discharge channel are all square channels, and the w...

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Abstract

The invention discloses a magnetic size-dependent microfluidic chip, which comprises a cover and a substrate, the cover and the substrate are sealed and connected, a magnetophoretic separation structure and a size sorting channel are provided on the lower surface of the cover, and the magnetophoretic The separation structure is used to separate the magnetic-target complex, and the size sorting channel is used to separate and capture magnetic microspheres of different sizes. The microfluidic chip has a simple structure, is easy to manufacture, and has low cost, and can complete all detection steps in the microcavity without moving an external magnet, thereby improving detection efficiency and accuracy.

Description

technical field [0001] The invention relates to the technical field of biological detection, in particular to a magnetic size-dependent microfluidic chip. Background technique [0002] Quantum dots have unique and superior optical properties, such as large extinction coefficient, high quantum yield, wide excitation spectrum, narrow emission spectrum, 10-100 times higher brightness than traditional fluorescent dyes, and 100 times higher photostability than traditional fluorescent dyes. Features such as -1000 times have been widely used in bioluminescence labeling, providing an important tool for the instant detection and typing of various substances to be detected. [0003] The Chinese patent "Microfluidic Chip for Quantitative Detection of Multiple Targets Based on Magnetic Particle Chemiluminescence" (CN105259164B) discloses a microfluidic chip, which moves an external magnet at a certain speed to make the sample and enzyme label The antibody reacts fully, releases differe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
CPCB01L3/5027B01L2200/10B01L2300/0861B01L2300/0887
Inventor 刘侃张泽芬
Owner WUHAN TEXTILE UNIV