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Preparation method of semen persicae formula granules

A technology of formula granules and peach kernels, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as peach kernel formula granules that have not yet been seen, to improve the physical dissolution transfer rate, reduce chemical changes, and prevent changes Effect

Inactive Publication Date: 2019-04-05
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on the preparation of peach kernel formula granules by continuous dynamic countercurrent extraction process

Method used

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  • Preparation method of semen persicae formula granules

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A preparation method of peach kernel formula granules, comprising the steps of:

[0042] a. Select peach kernel medicinal materials, shake and sieve to remove impurities, and crush them into 0.5cm particles to obtain peach kernel decoction pieces;

[0043] b. The crushed peach kernel decoction pieces are continuously input into the extraction tube of the spiral continuous countercurrent extraction machine (two-stage 10-section tube structure) from the feed port, and the material is continuously pushed forward through a set of spiral structures in the extraction tube. Extract the slag from the slag discharge port of the extraction tube, and continuously add 14 times the amount of 95°C hot water at the end of the extraction tube at each level for continuous countercurrent extraction for 1 hour, collect the extract, and squeeze the peach kernel medicinal residue to recover part of the medicinal liquid before Eject, the recovered part of the medicinal liquid is combined wit...

Embodiment 2

[0048] A preparation method of peach kernel formula granules, comprising the steps of:

[0049] a. Select peach kernel medicinal materials, shake and sieve to remove impurities, and crush them into 0.5cm particles to obtain peach kernel decoction pieces;

[0050] b. The crushed peach kernel decoction pieces are continuously input into the extraction tube of the spiral continuous countercurrent extraction machine (two-stage 10-section tube structure) from the feed port, and the material is continuously pushed forward through a set of spiral structures in the extraction tube. Extract the slag from the slag discharge port of the extraction tube, and continuously add 14 times the amount of 95°C hot water at the end of the extraction tube at each level for continuous countercurrent extraction for 1 hour, collect the extract, and squeeze the peach kernel medicinal residue to recover part of the medicinal liquid before Eject, the recovered part of the medicinal liquid is combined wit...

Embodiment 3

[0055] A preparation method of peach kernel formula granules, comprising the steps of:

[0056] a. Select peach kernel medicinal materials, shake and sieve to remove impurities, and crush them into 0.5cm particles to obtain peach kernel decoction pieces;

[0057] b. The crushed peach kernel decoction pieces are continuously input into the extraction tube of the spiral continuous countercurrent extraction machine (two-stage 10-section tube structure) from the feed port, and the material is continuously pushed forward through a set of spiral structures in the extraction tube. Extract the slag from the slag outlet of the extraction tube, and continuously add 14 times the amount of hot water at 95°C to the end of the extraction tube at each level for continuous countercurrent extraction for 1 hour, collect the extract, and discharge the peach kernel drug residue; the input speed of the peach kernel decoction pieces is 100kg / h, and the flow rate of reversely adding hot water is 140...

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Abstract

The invention discloses a preparation method of semen persicae formula granules. The preparation method comprises the steps that a, semen persicae is crushed or cut to obtain semen persicae decoctionpieces; b, the semen persicae decoction pieces are continuously input into extraction pipes of a continuous dynamic countercurrent extraction machine, hot water is reversely and continuously added atthe tail ends of the extraction pipes of each grade for continuous dynamic countercurrent extraction, and an extracting solution is collected; c, the extracting solution is filtered and subjected to superhigh temperature instantaneous sterilization, and filtrate is concentrated under reduced pressure to form a clear paste; d, excipients are added to the clear paste for dissolution, and spray drying is performed to obtain dry extract powder; and e, preparation excipients are added to the dry extract powder, and dry granulation is performed to obtain the semen persicae formula granules. The preparation method adopts a production process of continuous countercurrent extraction, superhigh temperature instantaneous sterilization, pressure-reduced concentration, spray drying and dry granulation,and researches various process parameters, so that the content of effective elements in the semen persicae formula granules can continuously and stably achieve a higher level, it is ensured that theactive ingredient transfer rate is consistent with semen persicae standard decoction, and the product quality of the semen persicae formula granules is improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a preparation method of peach kernel formula granules. Background technique [0002] Peach kernel is Rosaceae plant peach Prunus persica (L.) Batsch or Hickory Prunus davidiana (Carr.) The dried mature seeds of Franch. are recorded in the 2015 edition of "Chinese Pharmacopoeia". Carbuncle, injury from falling, intestinal dryness and constipation, cough and asthma. Modern studies have shown that one of the main active ingredients of peach kernels is amygdalin, which is an index compound for quality control in the "Chinese Pharmacopoeia". and immunomodulatory pharmacological effects. Amygdalin is easily decomposed by the amygdalin enzyme in the seeds when it meets water. The suitable temperature is 20~40°C to produce hydrocyanic acid and benzaldehyde. Hydrocyanic acid has a certain inhibitory effect on the respiratory center, m...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61K9/16A61P1/10A61P11/06A61P11/14A61P29/00A61P15/00A61P35/00A61P11/00A61P1/00
CPCA61K9/1611A61K9/1617A61K9/1623A61K9/1652A61K36/736A61K2236/15A61K2236/331A61K2236/51A61P1/00A61P1/10A61P11/00A61P11/06A61P11/14A61P15/00A61P29/00A61P35/00
Inventor 程学仁刘燎原张志鹏张雪兰邓李红杜泳祥蔡盛康
Owner GUANGDONG YIFANG PHARMA