Synthesis method of tertiary butyl-9-oxo-2,5,8-triazaspiro[3.5] nonane-2-carboxylate
A technology of a triazaspiro and a synthetic method, which is applied in the field of synthesis of tert-butyl-9-oxygenide-2,5,8-triazaspiro[3.5]nonane-2-carboxylate, capable of Solve the problems of no suitable industrial synthesis methods, etc., and achieve the effects of reasonable reaction process design, easy reaction, and strong repeatability
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0011] Ethylenediamine (5.27 g, 87.62 mmol, 5.86 mL) and benzyltriethylammonium chloride (665.20 mg, 2.92 mmol) were dissolved in chloroform (50.00 mL), and compound 1 (10.00 g, 58.41 mmol , 1.00 eq), and controlled the temperature at 0-10 °C, dissolved sodium hydroxide (11.68 g, 292.05 mmol, 5.00 eq) in water (11.68 mL), added dropwise to the above chloroform (50.00 mL) solution, and Control the temperature below 10°C, and then react at 25°C for 16 hours. After the reaction was complete, the organic layer was separated, the aqueous phase was extracted three times with chloroform, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated to obtain a crude product, which was separated and purified by column chromatography to obtain compound 2 as a white solid (5.6 g). Yield: 41 %. 1 HNMR: CDCl3 Varian_Y_400MHz, δ=4.363 (d, 2H), 3.656 (d, 2H), 3.362 (t, 2H), 3.012 (t, 2H), 1.417 (s, 9H).
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com