32results about How to "The reaction is easy to scale up" patented technology

The invention provides a preparation method of 3,3'-bisindole compounds. The preparation method comprises the following steps: adding 3-indolone derivatives, indole derivatives and a catalyst into a solvent, reacting and purifying. The reaction general formula of the preparation method is disclosed in the specification. The preparation method provided by the invention has the advantages of accessible raw materials, mild reaction conditions, simple synthesis steps, easy operation, easy separation and purification of the synthetic product, high yield of the target product, and easy amplification for reaction, and thus, has wide application prospects.

The invention relates to a preparation method of (2,4,5,7-tetrahydropyrano[3,4-c]pyrazol-7-yl)methanol, which mainly solves the technical problem that there is no suitable industrial synthesis method at present. The present invention is divided into ten steps: first, compound 1 and triethyl orthoformate generate compound 2 under the action of boron trifluoride ether, then react with benzylhydrazine to obtain compound 3, and react with acetyl chloride to obtain compound 4, then obtain compound 4 in two Add N-bromosuccinimide to the solution of methyl chloride to obtain compound 5, react with ethylene boron trifluoride potassium salt to obtain compound 6, and obtain compound 7 with sodium hydroxide, and obtain compound 7 with N-bromosuccinimide Compound 8 was obtained by the reaction, compound 9 was obtained under the action of methanesulfonic acid, compound 10 was obtained by reacting with silver nitrate in acetonitrile solution, and product 11 was obtained by reacting with hydrogen gas under the catalyst palladium carbon. The compounds obtained in the present invention are useful intermediates or products of many pharmaceutical synthesis.

The invention relates to a preparation method of tertiary butyl 1-hydroxyl-8-azaspirane[4,5]decane-8-carboxylic ester and mainly solves the technical problems that a method suitable for industrial synthesis does not exist at present. The preparation method comprises three steps: firstly, generating a compound 2 by a compound 1 under the action of hydrochloric acid; secondly, obtaining a compound 3 by enabling the compound 2 to react with di-tert-butyl dicarbonate in a mixed solution of dioxane and water under the existence of sodium carbonate; finally, obtaining a product 4 by treating the compound 3 through sodium borohydride, wherein a reaction formula is as shown in the description. The tertiary butyl 1-hydroxyl-8-azaspirane[4,5]decane-8-carboxylic ester obtained through the preparation method disclosed by the invention is a useful intermediate or a product compounded by many medicines.