47results about How to "Mild aftertreatment" patented technology

The invention relates to three novel compound formulas I, II and III for preparing suvorexant, stereoisomers or salt thereof and a preparation method of the formulas I, II and III. The invention also relates to a method for preparing the suvorexant. The preparation method disclosed by the invention can be used for synthesizing to obtain the chiral compounds I, II and III through a chiral initiator and use the chiral compounds I, II and III for the synthesis of the suvorexant and has the advantages of easiness for operation, moderation in reaction condition, easiness for post processing, easiness for purification, high yield, high ee value and easiness for industrialization.

The invention provides a method for rapidly producing biodiesel from kitchen garbage and produced biodiesel. The method comprises the following steps of: (1) carrying out pretreatment: enabling the kitchen garbage to be subjected to sorting, crushing and vacuum dewatering, thereby obtaining hogwash oil; (2) weighing methanol and the hogwash oil in accordance with that the mass ratio of the methanol to the hogwash oil is (50: 100) to (500: 100), and weighing a catalyst in accordance with that the catalyst accounts for 0.05-5% by mass of the oil; (3) dissolving the catalyst in the methanol, and adding the hogwash oil and the methanol where the catalyst is dissolved to an autoclave for reacting for 3-60 min at the temperature of 80-350 DEG C and the pressure of 1-10 MPa; and (4) after the reaction is completed, carrying out reduced-pressure distillation, recovering excessive methanol, and enabling a product to be subjected to standing for layering, wherein a lower layer is glycerine, and an upper layer is the biodiesel. The method provided by the invention has the characteristics of short reaction time, mild reaction conditions and simple product post-processing.

The invention discloses an NNN ligand, metal complexes thereof, preparation methods and application, and particularly provides an NNN ligand 1, a metal complex 2 of the NNN ligand, a metal complex 3 of the NNN ligand and preparation methods of the NNN ligand 1 and the metal complexes, as well as application of the metal complex 3 of the NNN ligand to catalysis on hydroboration reaction of bis-substituted olefin, especially application of the metal complex 3 to catalysis on asymmetric hydroboration reaction of 1, 1-bis-substituted olefin. The metal complex 3 of the NNN ligand has good catalytic activity in the hydroboration reaction of the bis-substituted olefin, especially asymmetric hydroboration reaction of the 1, 1-bis-substituted olefin, has excellent regioselectivity and enantioselectivity, and is high in yield and mild in reaction conditions; besides, the preparation methods of the NNN ligand and the metal complexes thereof are simple, environment-friendly, mild in reaction conditions, relatively high in yield, and simple in post-processing, and the raw materials are low in cost and easy to obtain, so that the preparation methods are suitable for industrial production. (The formulas of the NNN ligand 1, metal complex 2 and metal complex 3 are shown in the description).

The invention discloses a synthesizing method for an amide compound shown in formula (III). The synthesizing method comprises the following steps: adopting replacing acetonitrile shown in formula (I) and amines compound shown in formula (II) as raw materials in air atmosphere; adopting Ru/C as a catalyst; conducting reaction in solvent to generate the amide compound shown in formula (III); the solvent is one selected from ethyl alcohol, furanidine, methyl sulfoxide and o-dichlorobenzene. The synthesizing method being novel synthesizing route is simple to operate, convenient in post-treatment, high in product yield, and good in product purity; particularly, the catalyst and the solvent can be used repeatedly; air is taken as oxidant; not only production cost is reduced, but also the method is environmental-friendly, and very suitable for large-scale industrialization production.

The invention relates to a synthesis method which comprises the steps of taking uridine as a principal raw material, treating with iodine and dilute nitric acid, obtaining 5-iodine uridine, treating with acetic anhydride to form 2',3',5'-O-trioxide acetyl-5-iodine uridine, allowing 2',3',5'-O-trioxide acetyl-5-iodine uridine to react with 2-(tributyl stannane) furan or thiophene by the action of triphenyl phosphine palladium chloride to form an intermediate, deprotecting by stirring in an ammonia methanol saturated solution at the room temperature by the action of phosphorus pentasulfide, and obtaining 5-(2-furyl or thienyl)-4-sulfur-bearing uridine. The compound has absorption at 363nm, and higher sensitivity to ultraviolet A, can enter inner cells of a tissue and act on cancer cells selectively, and overcomes the disadvantages that a photosensitive reagent for optic treatment at present is not gathered in nuclei and cannot selectively act on the cancer cells. The compound belongs to a novel base sulfur-bearing nucleoside compound, absorption light waves of the compound are in a long wavelength region, and the compound can selectively act on the inner cancer cells of the tissue, has a potential pharmaceutical value, and enters the inner cells of the tissue easily.

The invention discloses a method for preparing an inorganic compound melamine hard foaming nano-material. The method comprises the following steps: A, causing melamine, paraformaldehyde and water to react to produce polyhydroxy melamine; B, adding an inorganic nano-material and a modifying agent into the polyhydroxy melamine to form a prepolymer resin solution; C, adding an emulsifying agent, a foaming agent, a foam stabilizer and a curing agent into the prepolymer resin solution, uniformly stirring, foaming in a microwave oven, and curing to obtain the inorganic compound melamine hard foaming nano-material. According to the method, an inorganic nano-material having an inorganically treated surface and the modifying agent are added into polyhydroxy melamine, so that the inorganic nano-material is directly dispersed in a resin system and participates in an acidic polycondensation process to form a crossed three-dimensional reticular structure with resin, and therefore, the product has the advantages of melamine and the special properties of nano-particles, and has the advantages of high strength, high modulus, good toughness, high temperature resistance and the like on mechanical performance.

The invention relates to Schiff base containing carbazyl and thiadiazolyl and a preparation method thereof; the preparation method comprises: adding acyl carbazole, 2-amino-5-substituted-1,3,4-thiadiazole and p-toluenesulfonic acid, grinding at room temperature, performing TLC (thin layer chromatography) monitoring on reaction until the materials react completely, and standing to obtain a crude product, wherein a molar ratio of the acyl carbazole, 2-amino-5-substituted-1,3,4-thiadiazole and p-toluenesulfonic acid is 1:A:B, and wherein A is 1-1.2 or 2-2.2, and B is 1-1.2 or 2-2.2; subjecting the crude product to washing and suction filtering to obtain the Schiff base containing carbazyl and thiadiazolyl. The reaction time is short, reaction conditions are mild, reacting may be performed at room temperature, equipment requirements are low, post-processing is simple, no solvents are required, and the yield is high; the Schiff base containing carbazyl and thiadiazolyl prepared herein contains multiple C=N fluorescent groups and carbazole groups with good hole transport capacity, and have certain luminescent properties.

The invention relates to a 4-amino-5-substituted-1,2,4-triazole-3-thione Schiff base and a preparation method thereof. The preparation method comprises: adding A mol of 4-amino-5-substituted-1,2,4-triazole-3-thione, B mol of benzaldehyde or substituted benzaldehyde and C mol of p-toluene sulfonic acid to a dried reaction container, grinding the raw materials at a room temperature until the raw materials completely react, and standing to obtain a crude product, wherein a ratio of A to B to C is 1:(1-1.2):(1-1.2); and dissolving the crude product with a solvent, carrying out suction filtration, and concentrating the filtrate until achieving a dry state to obtain the 4-amino-5-substituted-1,2,4-triazole-3-thione Schiff base. According to the present invention, the preparation method adopts the solid phase reaction, the reaction time is short, the reaction conditions are mild, the equipment requirements are low, the operations are simple, the post-treatment is simple, the solvent is not required, characteristics of green, economy and environmental protection are provided, and the yield of the target product is up to more than 86%.

The invention relates to a schiff base containing a carbazolyl group and an oxadiazole group and a preparing method thereof. The method includes the steps that acylcarbazole, 2-amino-5-substituted-1,3,4-oxadiazole and p-toluenesulfonic acid are added into a dry reaction container and ground under the room temperature condition, TLC is used for monitoring the reaction until the raw materials react completely, and a crude product is obtained after standing, wherein the molar ratio of acylcarbazole: 2-amino-5-substituted-1,3,4-oxadiazole: p-toluenesulfonic acid is 1:A:B, wherein the range of A is 1-1.2 or 2-2.2, and the range of B is 1-1.2 or 2-2.2; the schiff base containing the carbazolyl group and the oxadiazole group is obtained after the crude product is washed and filtered in a suction mode. The preparing method is high in reactivity, high in reaction speed and short in reaction time, and the schiff base containing the carbazolyl group and the oxadiazole group contains multiple C=N fluorescent groups and the carbazole group with high hole-transport capacity and has a certain luminescence property.

The invention discloses a method for synthesizing a compound ticagrelor and a synthesized intermediate thereby. The method comprises the following steps: carrying out a substitution reaction between a compound (2) and a compound (3) to prepare a compound (4); carrying out a reduction reaction on the compound (4) to prepare a compound (5); carrying out a chlorination reaction on the compound (5) to prepare a compound (6); carrying out a substitution reaction between the compound (6) and a compound (7) to prepare a compound (8); and finally, carrying out a hydroxyl deprotection reaction on the compound (8), thereby obtaining the ticagrelor (1). The reaction formulas are as shown in the specification. The invention provides a novel method for synthesizing ticagrelor. The synthetic method has the advantages of novel technical route, simple and convenient operation, high synthesis yield, high product purity, cheap and readily available raw materials and the like, and is suitable for industrialized production. Meanwhile, the synthesized ticagrelor intermediate provides a novel intermediate raw material for preparation of the ticagrelor.

The invention discloses a supported catalyst and application thereof in preparation of hydroxyalkyl acrylate. The catalyst is obtained by loading any elemental substance of magnesium, calcium, iron, copper, zinc or aluminum, oxide, sulfate and halide onto a carrier, wherein the weight ratio of the elemental substance of magnesium, calcium, iron, copper, zinc and aluminum, the oxide, the sulfate and the halide is 1:(1-3):(1-10):(1-5), and the weight of the carrier is 1-5 times of the total weight of the elemental substance of magnesium, calcium, iron, copper, zinc and aluminum, the oxide, the sulfate and the halide. The catalyst used in the invention has the advantages of cheap and easily available components, low manufacturing cost, simple operation process, mild conditions, convenient post-treatment, high activity, long service lifetime, and capable of being regenerated and reused. The process of utilizing the catalyst for preparing hydroxyalkyl acrylate is simple, the production process is safe, no polymerization inhibitor is needed, continuous operation can be performed, the raw material conversion rate is 96% or above, and the product purity is 99% or above.

The invention discloses a phosphine pyridine oxazoline compound, a metal complex, and a preparation method and application thereof. According to the invention, the preparation methods of the phosphinepyridine oxazoline compound and the metal complex are simple, wherein the raw materials are cheap and easy to obtain, the process is environmentally friendly, reaction conditions are mild, the yieldis high, aftertreatment is simple, and large-scale production is easy. The phosphine pyridine oxazoline compound has chiral induction capability and can be complexed with metal cobalt or iron to forma chiral metal complex of the phosphine pyridine oxazoline compound. The metal complex disclosed by the invention has excellent catalytic activity in asymmetric hydrogenation reaction of alpha-alkenylsilicon, particularly in asymmetric hydrogenation reaction of alpha-silicon-based styrene compounds, and is excellent in enantioselectivity, high in yield and mild in reaction condition.

The invention discloses alkyl-substituted ethyl acetate-based guanidine ionic liquid as well as preparation and application thereof, which are characterized in that tetramethylguanidine and 2-bromo ester are ionized to obtain alkyl-substituted ethyl acetate-based guanidine ionic liquid, and the alkyl-substituted ethyl acetate-based guanidine ionic liquid is applied as a catalyst to formylation and methylation reactions of carbon dioxide, N-methylaniline and derivatives of the N-methylaniline to selectively generate N-methylformylaniline or N, N-dimethylaniline and derivatives thereof. Compared with the prior art, the alkyl-substituted ethyl acetate-based guanidine ionic liquid has the advantages of good catalytic performance, mild reaction conditions, simple post-treatment, simple synthesis, low cost, greenness and high efficiency, avoids the use of a large amount of organic solvents when being used as a solvent and a catalyst at the same time, and has important meanings in the research of medicinal chemistry and medical intermediate compounds.

Belonging to the field of polymer synthesis, the invention relates to a preparation method of high molecular weight branched polymers. The method includes: taking an alcoholic hydroxyl monomer as a hydroxyl monomer, adopting acrylic ester as a double-bond monomer, catalyzing the Oxa-Michael addition polymerization of hydroxyl and unsaturated double or triple bond in an organic solvent by organophosphorus nitrile base t-BuP2, thus preparing high molecular weight branched polymers with different terminal groups. The branched polymers prepared by the method provided by the invention have the characteristics of controllable and modifiable structure, and are suitable for application in different fields. The method has the advantages of mild reaction conditions, fast reaction, high efficiency and high yield, and the required monomers are all commercial monomers, the catalyst is free of metal residue, safe and environment-friendly, therefore the high molecular weight branched polymers can beused for large-scale production and application, and have huge application prospects.

The invention discloses an NCP ligand, a metal iridium complex thereof, and a preparation method and application of the complex. The NCP ligand has a structure as shown in a formula 1, and can be complexed with metal iridium to form the chiral metal iridium complex of the NCP ligand as shown in a formula 2, and the complex has excellent catalytic activity in hydrogenation reaction of diaryl substituted olefin, and has the advantages of better regioselectivity, better enantioselectivity, high yield, mild reaction conditions and the like especially in asymmetric transfer hydrogenation reaction.