47results about How to "Mild aftertreatment" patented technology

The invention discloses an NNN ligand, metal complexes thereof, preparation methods and application, and particularly provides an NNN ligand 1, a metal complex 2 of the NNN ligand, a metal complex 3 of the NNN ligand and preparation methods of the NNN ligand 1 and the metal complexes, as well as application of the metal complex 3 of the NNN ligand to catalysis on hydroboration reaction of bis-substituted olefin, especially application of the metal complex 3 to catalysis on asymmetric hydroboration reaction of 1, 1-bis-substituted olefin. The metal complex 3 of the NNN ligand has good catalytic activity in the hydroboration reaction of the bis-substituted olefin, especially asymmetric hydroboration reaction of the 1, 1-bis-substituted olefin, has excellent regioselectivity and enantioselectivity, and is high in yield and mild in reaction conditions; besides, the preparation methods of the NNN ligand and the metal complexes thereof are simple, environment-friendly, mild in reaction conditions, relatively high in yield, and simple in post-processing, and the raw materials are low in cost and easy to obtain, so that the preparation methods are suitable for industrial production. (The formulas of the NNN ligand 1, metal complex 2 and metal complex 3 are shown in the description).

The invention discloses a preparation method of a 7,8-dihydroquinoline-2,5(1H,6H)-dione derivative represented by formula (I), the preparation method comprising the following steps: as shown in formula (I) The Baylis-Hillman adduct represented by (II) reacts with 1,3-cyclohexanedione represented by formula (III) or 1,3-cyclohexanedione represented by formula (III) under the action of a base catalyst at 0~100°C in an organic solvent or under solvent-free conditions. The derivative is reacted for 1-12 hours, then primary amine is added to react at 0-100° C. for 1-8 hours, and the compound of formula (I) can be obtained after post-treatment. Compared with the prior art, the present invention is mainly embodied in easy availability of raw materials, simple and convenient operation, mild reaction conditions, high reaction yield, good atom economy, and low environmental pollution, so it has greater practical value and potential social and economic benefits.

The invention relates to a preparation method of a dihydropyridine raw material drug, comprising the following steps: putting ethyl acetoacetate and urotropine into a reaction kettle, mixing them at 15-20°C; slowly adding ethanolamine dropwise, and raising the temperature after the dropwise addition Reaction: cool down to crystallize, centrifuge to obtain crude dihydropyridine; add ethanol and crude dihydropyridine to the refining kettle, heat and stir to dissolve, adjust pH to neutral with glacial acetic acid, add activated carbon, stir for 1 hour, and then press into Crystallization kettle; crystallization at lower temperature, centrifugation, and vacuum drying to obtain dihydropyridine raw material medicine. The reaction process of the invention does not use organic solvents, has simple operation, less environmental pollution, mild reaction conditions, high safety, low cost, good product quality and is beneficial to industrialization.

The invention discloses a method for synthesizing a compound ticagrelor and a synthesized intermediate thereby. The method comprises the following steps: carrying out a substitution reaction between a compound (2) and a compound (3) to prepare a compound (4); carrying out a reduction reaction on the compound (4) to prepare a compound (5); carrying out a chlorination reaction on the compound (5) to prepare a compound (6); carrying out a substitution reaction between the compound (6) and a compound (7) to prepare a compound (8); and finally, carrying out a hydroxyl deprotection reaction on the compound (8), thereby obtaining the ticagrelor (1). The reaction formulas are as shown in the specification. The invention provides a novel method for synthesizing ticagrelor. The synthetic method has the advantages of novel technical route, simple and convenient operation, high synthesis yield, high product purity, cheap and readily available raw materials and the like, and is suitable for industrialized production. Meanwhile, the synthesized ticagrelor intermediate provides a novel intermediate raw material for preparation of the ticagrelor.

The invention discloses a method for synthesizing alpha- pyranone derivant demonstrated in formula (I). It comprises following steps: carrying out cyclic reaction with affixture of Baylis-Hillman and1, 3- cyclohexanone and its derivant demonstrated in formula (III) under catalytic action of alkali and with existence of organic disslovant or without disslovant at subzero 20 to 10 Deg. C, reactingfor 1- 12 hours, post-treating after reaction and getting said alpha- pyranone derivant. The invention is characterized by easy got raw material, simple and safe operation, temperate reaction condition, high productivity, simple post-treatment, little environmental pollution, and great performing value and social and economic benefit.

The invention discloses a carbon fiber modified by a crystalline crosslinkable polyaryletherketone sizing agent and a preparation method thereof, belonging to the technical field of carbon fiber surface treatment. The present invention utilizes difluoro monomers containing aniline side groups and bisphenol monomers to polymerize, or to modify crystalline polyaryletherketones to obtain soluble amorphous polyaryletherketone polymers, and then heat-induced crosslinking The group is capped at both ends of the polymer; at the same time, the surface of the carbon fiber is electrochemically reduced, and the same cross-linking group as mentioned above is grafted to the surface of the carbon fiber; then the carbon fiber whose surface has been treated by electrochemical reduction is drawn through the sizing agent The solution is sized and acidified to restore the crystallinity of the polyaryletherketone sizing agent; finally, after the carbon fiber is processed and formed to prepare the composite material, a high-temperature heat treatment is carried out to initiate the crosslinking reaction, and to improve the crystallization degree of the polyaryletherketone polymer, so that the sizing The agent has a crystalline structure, and at the same time forms a chemical bond connection with the surface of the carbon fiber, improves the interfacial shear strength, and is resistant to high temperature and corrosion.