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Therapeutic drug for nonalcoholic fatty liver disease

A fatty liver disease, non-alcoholic technology, applied in drug combinations, viral peptides, pharmaceutical formulations, etc.

Inactive Publication Date: 2019-04-26
SHANGHAI HEP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When NASH develops into liver cirrhosis and liver failure, corresponding symptoms and signs may appear, which are indistinguishable from liver cirrhosis and liver failure caused by other causes

Method used

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  • Therapeutic drug for nonalcoholic fatty liver disease
  • Therapeutic drug for nonalcoholic fatty liver disease
  • Therapeutic drug for nonalcoholic fatty liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0143]This example uses the mouse model of nonalcoholic steatohepatitis (NSAH) to evaluate the effect of hepalatide (L47) on the metabolic level and pathological changes of NASH, and to determine whether L47 can improve NASH lesions. Pharmacodynamic evaluation provides a reference.

[0144] 1. Experimental materials and methods

[0145] 1. Experimental materials

[0146] Hepalatide (L47); preparation method: Weigh the required L47 into a 15ml centrifuge tube, add the required volume of 1X PBS buffer, shake and shake well, and prepare it immediately.

[0147] Preparation method: preparation of PBS buffer mother solution:

[0148] Liquid A: 0.2M Na 2 HPO 4 : Weigh 71.6g Na 2 HPO 4 -12H 2 O, 8g NaCl, dissolved in 1000ml water;

[0149] Solution B: 0.2M NaH 2 PO 4 : Weigh 31.2g NaH 2 PO 4 -2H 2 O, 8g NaCl, dissolved in 1000ml water;

[0150] 20X PBS buffer preparation: mix 81ml of solution A and 19ml of solution B to make 100ml;

[0151] 1X PBS buffer preparation: T...

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PUM

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Abstract

The invention relates to a therapeutic drug for nonalcoholic fatty liver disease. In particular, the invention relates to a use of a polypeptide comprising an amino acid sequence derived from hepatitis B virus (HBV) or a pharmaceutical composition thereof in the preparation of a medicament for treating or preventing nonalcoholic fatty liver disease.

Description

technical field [0001] The invention relates to a medicine for treating nonalcoholic fatty liver disease. Background technique [0002] Nonalcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome with liver histological changes similar to alcoholic liver disease but without a history of excessive alcohol consumption. It is an acquired metabolic disease closely related to insulin resistance and genetic susceptibility. The pathological changes of stress-induced liver injury include simple fatty liver (SFL), non-alcoholic steatohepatitis (NASH), fatty liver fibrosis, and liver cirrhosis as the disease progresses. [0003] Insulin resistance is closely associated with risk factors for nonalcoholic fatty liver disease. Recent studies have shown that almost all patients with nonalcoholic fatty liver have insulin resistance in peripheral tissues and liver, and not necessarily accompanied by abnormal glucose tolerance or obesity, but the severity of insulin resistanc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61P1/16
CPCA61K38/162A61K38/16A61P1/16C07K14/02
Inventor 刘宏利
Owner SHANGHAI HEP PHARMA