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Anti-myeloma drug-loaded microspheres with targeting and response slow-release properties and preparation method

A technology of drug-loaded microspheres and myeloma, which is applied in the field of biomedicine, can solve the problems of human body toxicity and side effects, and achieve the effect of no biological toxicity, target effect and simple process

Active Publication Date: 2022-03-25
EAST CHINA JIAOTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the research and development of drug carrier polymer materials has received a lot of attention, because it enters the body with drugs, some stay in the body temporarily, and some are degraded and absorbed in the body, so it may cause toxic and side effects to the human body

Method used

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  • Anti-myeloma drug-loaded microspheres with targeting and response slow-release properties and preparation method
  • Anti-myeloma drug-loaded microspheres with targeting and response slow-release properties and preparation method
  • Anti-myeloma drug-loaded microspheres with targeting and response slow-release properties and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: At room temperature, 30ml of a 2.5% calcium chloride aqueous solution was poured into a three-necked flask containing 150ml of MMT aqueous suspension at a constant speed, mechanically stirred for 4 hours, and thoroughly mixed. Slowly add 30ml mass concentration of 5%Na 2 CO 3 Aqueous solution, while controlling the pH at 7, after the dropwise addition of the solution, continue to stir for 2 hours, let stand for aging for 24 hours, filter and wash with suction, dry in an oven at 80°C for 2 hours, and roast in a tube furnace for 1 hour. After grinding the roasted product, configure it into an aqueous suspension with a mass concentration of 5%, add 10 ml of an aqueous sodium dihydrogen phosphate solution with a concentration of 0.1 mol / L dropwise into the suspension, stir it mechanically for 0.5 h, and transfer the mixed solution to In a polytetrafluoroethylene-lined hydrothermal reaction kettle, react at 120° C. for 1 hour, pour out the product in the hydrothe...

Embodiment 2

[0025] Example 2: At room temperature, 30 ml of a 1% calcium chloride aqueous solution was poured into a three-necked flask containing 150 ml of MMT aqueous suspension at a constant speed, mechanically stirred for 4 hours, and thoroughly mixed. Slowly add 30ml mass concentration of 2%Na 2 CO 3 Aqueous solution, while controlling the pH at 8, after adding the solution dropwise, continue to stir for 2 hours, let stand for aging for 24 hours, filter and wash with suction, dry in an oven at 80°C for 2 hours, and roast in a tube furnace for 1 hour. After grinding the roasted product, configure it into an aqueous suspension with a mass concentration of 5%, add 10 ml of a disodium hydrogen phosphate aqueous solution with a concentration of 0.1 mol / L dropwise into the suspension, stir it mechanically for 0.5 h, and transfer the mixed solution to In a polytetrafluoroethylene-lined hydrothermal reaction kettle, react at 120° C. for 1 hour, pour out the product in the hydrothermal react...

Embodiment 3

[0026] Example 3: At room temperature, 30 ml of a 5% calcium chloride aqueous solution was poured into a three-necked flask containing 150 ml of MMT water suspension at a constant speed, mechanically stirred for 4 hours, and thoroughly mixed. Slowly add 30ml mass concentration of 8%Na 2 CO 3Aqueous solution, while controlling the pH at 7, after the dropwise addition of the solution, continue to stir for 2 hours, let stand for aging for 24 hours, filter and wash with suction, dry in an oven at 80°C for 2 hours, and roast in a tube furnace for 1 hour. After grinding the roasted product, configure it into an aqueous suspension with a mass concentration of 5%, add 10 ml of a disodium hydrogen phosphate aqueous solution with a concentration of 0.1 mol / L dropwise into the suspension, stir it mechanically for 0.5 h, and transfer the mixed solution to In a polytetrafluoroethylene-lined hydrothermal reaction kettle, react at 120° C. for 1 hour, pour out the product in the hydrothermal...

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Abstract

An anti-myeloma drug-loaded microsphere with targeted and responsive slow-release properties and a preparation method thereof, the method uses layered montmorillonite as a support carrier, and synthesizes particle sizes between montmorillonite layers through cation exchange Controllable Spherical Nano-CaCO3, Preparation of MMT‑NanoCaCO 3 as the precursor template; through anion exchange, spherical NanoCaCO 3 Transform into nano-HAp to obtain HAp-MMT drug carrier; at the same time, connect chitosan oligosaccharide as a linker through electrostatic adsorption on the surface of MMT; use chitosan oligosaccharide amino terminal to covalently bind carboxyl terminal to introduce anti-myeloma cell targeting properties Polypeptide A54, preparing a drug-loaded microsphere with active targeting and pH-responsive slow-release functions. The method of the invention is simple in process, and the chemical reagents used are all common reagents. The prepared drug-loaded microspheres have both pH response characteristics and strong drug loading capacity. targeting effect. The vector aids in bone repair during myeloma healing.

Description

technical field [0001] The invention relates to an anti-myeloma drug-loaded microsphere with targeting and response slow-release characteristics and a preparation method, belonging to the technical field of biomedicine. Background technique [0002] Multiple myeloma (multiple myeloma, MM) is a malignant proliferative disease originating from plasma cells. The monoclonal immunoglobulin produced and secreted by myeloma cells, and the cytokines secreted by plasma cells and bone marrow stromal cells eventually lead to Multiple myeloma clinical symptoms including anemia, renal insufficiency, hypercalcemia, and bone pain (CRAB). MM is the second largest tumor of the blood system. The annual incidence of MM in North America, Europe and Asia is about 3.5-4.5 / 100,000, 2.5-3.5 / 100,000, and 0.5-2.0 / 100,000, respectively. Dr. Akana Swami of the United States recently published a research paper in the Proceedings of the National Academy of Sciences of the United States, saying that the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K47/64A61K47/60A61K47/54A61P35/00
CPCA61K47/549A61K47/60A61K47/64A61K47/6923A61P35/00
Inventor 王少会温博谈逸茗王少民谌芸谢小丽
Owner EAST CHINA JIAOTONG UNIVERSITY
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