Biomarker of second subtype of osteoarthritis and purpose

A technology for osteoarthritis and biomarkers, applied in biological testing, material inspection products, etc.

Active Publication Date: 2019-05-03
ZHEJIANG UNIV
View PDF9 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Based on the current status of molecular research on osteoarthritis, it can be found that many studies have revealed the common signaling pathway of osteoarthritis, which h

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biomarker of second subtype of osteoarthritis and purpose
  • Biomarker of second subtype of osteoarthritis and purpose
  • Biomarker of second subtype of osteoarthritis and purpose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0039] In order to describe the present invention more specifically, the technical solutions of the present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments. These descriptions only show how the present invention is realized, and cannot limit the specific scope of the present invention.

[0040] The present invention is based on the transcriptomics method for knee arthritis disease typing and the discovery of disease subtype marker genes. The specific steps are as follows:

[0041] Implementation Example 1: Collecting Cases

[0042] Collection of patient samples from multiple centers, this study collected knee joints from patients undergoing bone and joint replacement surgery at four hospitals. Cartilage tissue, subchondral bone tissue and synovial tissue were extracted from the patient.

[0043] Implementation example 2: cDNA library construction and RNA-seq sequencing of samples

[0044]Tissue Sample Ac...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a biomarker of the second subtype of osteoarthritis and the purpose. The purpose of biological substance in the metabolic pathway of collagen degradation and/or collagen fibrillation in the diagnosis of osteoarthritis is mainly involved.

Description

technical field [0001] The present invention relates to a method for typing knee arthritis based on transcriptomics and the detection of disease subtype marker genes and pathways, in particular, it belongs to the type of osteoarthritis diagnosed by using biomarkers. technical background [0002] Osteoarthritis (OA) is one of the most common musculoskeletal diseases encountered in all countries worldwide. In Europe, there is a case of bone and joint replacement surgery every minute and a half; 50% of people over the age of 65 suffer from osteoarthritis worldwide; in China, 25.3% of people over the age of 50 suffer from osteoarthritis. The clinical symptoms of osteoarthritis are pain and joint dysfunction. The progressive decline of joint function leads to the loss of joint mobility and functional limitation; thus, the patient's activities are limited and the quality of life is reduced; about 25% of OA patients cannot complete the main activities in normal life. Osteoarthrit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G01N33/68
Inventor 欧阳宏伟原春晖潘宗友盛紫璇
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap