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A kind of anti-inflammatory pharmaceutical composition and its application

The technology of an anti-inflammatory drug and composition, applied in the field of medicine, can solve the problems of insufficient anti-inflammatory effect, poor water solubility of cannabidiol, low cytotoxicity and the like

Active Publication Date: 2021-05-28
YANTAI HEMP BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the defects of poor water solubility and insufficient anti-inflammatory effect of existing cannabidiol, the present invention provides an anti-inflammatory pharmaceutical composition containing danshenin and cannabidiol, which are defined in the present invention It can synergize under the weight ratio, improve anti-inflammatory effect, low cytotoxicity, and Danshensu can promote the dissolution of cannabidiol

Method used

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  • A kind of anti-inflammatory pharmaceutical composition and its application
  • A kind of anti-inflammatory pharmaceutical composition and its application
  • A kind of anti-inflammatory pharmaceutical composition and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 Danshensu + cannabidiol injection freeze-dried preparation

[0028] prescription:

[0029]

[0030] Operation: Weigh the prescribed amount of cannabidiol and danshensu, add cannabidiol to the oily danshensu, stir to form a uniform transparent solution; weigh the prescribed amount of sodium chloride and mannitol, add 50% of the prescribed amount of Water for injection, stirring to dissolve, adding the above-mentioned Danshensu dissolved in cannabidiol, stirring to dissolve, replenishing water for injection.

[0031] Add 0.15% activated carbon for needles by mass, stir for 25 minutes, filter for decarburization, check the intermediate, filter and sterilize with a 0.22 μm filter membrane after passing the test, pour the filtrate into a vial, and freeze-dry to obtain freeze-dried powder for injection , after passing the inspection, pack.

Embodiment 2

[0032] The preparation of embodiment 2 danshensu+cannabidiol dropping pills

[0033] prescription:

[0034]

[0035] Operation: Weigh the prescribed amount of cannabidiol and danshensu, add cannabidiol to the oily danshensu, stir to form a uniform transparent solution; weigh the prescribed amount of PEG400, PEG4000, sodium carboxymethyl starch, povidone K30, put into the dripping pill machine and melt at 95°C, add the above-mentioned Danshensu dissolved in cannabidiol while stirring, mix well, the temperature of the medicinal material is 85°C, the medicinal material is dropped at a distance of 20cm, and the dripping speed is 28 drops / min Drop into liquid paraffin, condense at 10°C, solidify to form drop pills, take out and dry to obtain.

Embodiment 3

[0036] The preparation of embodiment 3 danshensu+cannabidiol injection emulsion

[0037] prescription:

[0038]

[0039]

[0040] Operation: Weigh the prescribed amount of cannabidiol and danshensu, add cannabidiol to the oily danshensu, stir to form a uniform and transparent solution; weigh the prescribed amount of glycerin, add an appropriate amount of water for injection, dissolve, and make glycerin Aqueous solution, keep warm at 50-60°C, as the water phase; weigh the prescribed amount of phospholipid, poloxamer and soybean oil, mix, stir and dissolve at 50-70°C, and use it as the oil phase; Add phenolic danshensu into the oil phase, stir to mix evenly, add to the water phase while shearing, high-speed shearing to form uniform colostrum, and use water for injection to make the volume to 5000mL, pass through a homogenizer to obtain uniform particle size, Lipid microspheres with an average particle size of 160-280nm; the prepared liquid is filtered through a 0.22 μm me...

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Abstract

The present invention provides an anti-inflammatory pharmaceutical composition and its application, and relates to the field of medical technology. In the anti-inflammatory pharmaceutical composition, Danshensu and Cannabidiol are included; the weight ratio of Danshensu and Cannabidiol is 1:(0.01 ~100). The research of the present invention shows that danshensu can be used as a solubilizer to improve the dissolution of cannabidiol, and the anti-inflammatory drug composition has high water solubility and good rehydration property. Under the weight ratio defined by the invention, the danshensu and the cannabidiol have a synergistic effect, the anti-inflammatory effect is significantly improved, and the cytotoxicity is small. The anti-inflammatory pharmaceutical composition of the invention can be used in the preparation of medicines for preventing or treating inflammation, and provides a new approach for the treatment of inflammation-related diseases.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an anti-inflammatory pharmaceutical composition and its application. Background technique [0002] Inflammatory response is a common pathological process in clinical practice. It is a complex defense response of biological organisms with vascular system to damage factors (such as allergic reactions produced by bacteria, viruses, antigens, and nuclear antibodies, etc.), and can occur in various parts of the body. Tissues and organs of the site. When the inflammatory factors act on the body, the body eliminates the inflammatory factors through the inflammatory response, which is a process of injury and anti-injury. Many common diseases, such as folliculitis, tonsillitis, pneumonia, hepatitis, pancreatitis, nephritis, etc., as well as autoimmune diseases, atherosclerosis, wound repair, etc., all belong to the category of inflammation. Anti-inflammatory drugs are the second larges...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/192A61P29/00A61P1/18A61P19/02A61P1/04A61P1/00A61P25/00A61P17/02A61K31/05
Inventor 曲桂武崔明
Owner YANTAI HEMP BIOTECHNOLOGY CO LTD
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