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Traditional Chinese medicine composition for treating ulcerative colitis

A technology for ulcerative colitis and composition, applied in the directions of drug combination, antipyretic, anti-inflammatory agent, etc.

Pending Publication Date: 2019-05-07
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But about the application of Chinese medicine composition of the present invention in the treatment of ulcerative colitis, there is no report yet

Method used

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  • Traditional Chinese medicine composition for treating ulcerative colitis
  • Traditional Chinese medicine composition for treating ulcerative colitis
  • Traditional Chinese medicine composition for treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 treats the preparation (1) of the Chinese medicine composition of treating ulcerative colitis

[0020] 30 parts of verbena, 30 parts of purslane, 30 parts of Dijincao, 15 parts of betel nut, 15 parts of citrus aurantium, 15 parts of angelica, decoct according to the conventional method.

Embodiment 2

[0021] Embodiment 2 treats the preparation of the Chinese medicine composition of treatment ulcerative colitis (two)

[0022] 33 parts of verbena, 33 parts of purslane, 30 parts of Dijincao, 15 parts of betel nut, 12 parts of citrus aurantium, 12 parts of angelica, decoct according to conventional methods.

Embodiment 3

[0023] Embodiment 3 treats the preparation of the Chinese medicine composition of treatment ulcerative colitis (three)

[0024] 30 parts of verbena, 30 parts of purslane, 27 parts of Dijincao, 12 parts of betel nut, 18 parts of citrus aurantium, 18 parts of angelica, decoct according to the conventional method.

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Abstract

The present invention relates to a traditional Chinese medicine composition for treating ulcerative colitis. The traditional Chinese medicine composition comprises 27-33 parts of verbena officinalis,27-33 parts of herba portulacae, 27-33 parts of humifuse euphorbia herb, 12-18 parts of betel nut, 12-18 parts of immature bitter oranges and 12-18 parts of angelica sinensis. The present invention also relates to an application of the traditional Chinese medicine composition. A therapeutic effect and a mechanism of the traditional Chinese medicine composition for the ulcerative colitis are studied by establishing a rat ulcerative colitis model. An experiment proves that the traditional Chinese medicine composition can significantly improve DAI score and colon tissue pathological injury of UCrats, at the same time can also significantly inhibit activation of I kappa B / NF-kappa B, thus reduces levels of IL-1 beta, TNF-alpha, etc., inhibits inflammation, and also has an effect significantlybetter than that in a SASP group.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating ulcerative colitis. Background technique [0002] Ulcerative colitis (UC) is a chronic, non-specific enteropathy that mainly occurs in the mucosal layer of the rectum and colon, mainly with ulcers and erosions, mostly involving the distal colon, and can also spread throughout the entire colon. Most of the onset is slow, and a few are acute and catastrophic outbreaks. The course of the disease is long, often recurrent, and can be seen at any age. Bloody diarrhea is the most common early symptom, which can also manifest as abdominal pain, blood in the stool, weight loss, tenesmus, vomiting, etc., and occasionally arthritis, iridocyclitis, liver dysfunction, skin lesions, and fever. Its etiology and pathogenesis are not yet clear, and it may be related to factors such as genetics, infection, and immune a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61P1/00A61P1/04A61P29/00
Inventor 窦丹波顾思臻王宇陈凯俊李鹏帆张玉丽
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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