Hierarchical-pore-containing bioactive glass/polylactic acid-glycolic acid copolymer composite scaffold and preparation method thereof

A technology of bioactive glass and glycolic acid, which is applied in the field of preparation of biomedical materials, achieves the effects of stable quality, good osteoinductive ability, and favorable infiltration of body fluids

Inactive Publication Date: 2019-05-14
SOUTH CHINA UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The purpose of the present invention is to provide a bioactive glass / polylactic-co-glycolic acid (PLGA) composite scaffold with a hierarchical porous structure and a preparation method thereof, aiming at the structural defects of the existing scaffolds. Hierarchical porous repair scaffold with bioactivity and osteoinductive ability, biomimetic natural bone structure and composition, promoting bone tissue repair and regeneration

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  • Hierarchical-pore-containing bioactive glass/polylactic acid-glycolic acid copolymer composite scaffold and preparation method thereof
  • Hierarchical-pore-containing bioactive glass/polylactic acid-glycolic acid copolymer composite scaffold and preparation method thereof
  • Hierarchical-pore-containing bioactive glass/polylactic acid-glycolic acid copolymer composite scaffold and preparation method thereof

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Effect test

Embodiment 1

[0035] A bioactive glass / polylactic-co-glycolic acid (PLGA) composite scaffold containing a hierarchical pore structure, the preparation method of which is as follows:

[0036] (1) Preparation steps of bioactive glass powder:

[0037] First add 40 g of dodecylamine (DDA) to a mixed solution of 250 mL of deionized water and 800 mL of absolute ethanol, and then place it in a constant temperature water bath at 40°C for magnetic stirring until the dodecylamine is completely dissolved; Add 217.34 mL tetraethyl orthosilicate to the pump at a speed of 0.5 mL / min. During this process, due to the gradual formation of the Si network, the solution becomes turbid and becomes milky white; then add 22.02 mL triethyl phosphate at a speed of 0.5 mL / min with a syringe pump Then, dissolve 137.47 g of calcium nitrate tetrahydrate in 200 mL of deionized water, slowly add to the reaction solution, continue to stir for 3 h, and age at room temperature for 24 h; finally, centrifuge the glass sol to ...

Embodiment 2

[0041]A bioactive glass / polylactic-co-glycolic acid (PLGA) composite scaffold containing a hierarchical pore structure, the preparation method of which is as follows:

[0042] (1) Preparation steps of bioactive glass powder:

[0043] First add 4 g of dodecylamine (DDA) into a mixed solution of 25 mL of deionized water and 80 mL of absolute ethanol, and then place it in a constant temperature water bath at 40°C for magnetic stirring until the dodecylamine is completely dissolved; Add 21.73 mL tetraethyl orthosilicate to the pump at a speed of 0.5 mL / min. During this process, due to the gradual formation of the Si network, the solution becomes turbid and becomes milky white; then add 2.2 mL triethyl phosphate at a speed of 0.5 mL / min with a syringe pump. ester; then dissolve 13.75 g calcium nitrate tetrahydrate in 200 mL deionized water, slowly add into the reaction solution, continue to stir for 3 h, and age at room temperature for 24 h; finally, centrifuge the glass sol to obt...

Embodiment 3

[0047] A bioactive glass / polylactic-co-glycolic acid (PLGA) composite scaffold containing a hierarchical pore structure, the preparation method of which is as follows:

[0048] (1) Preparation steps of bioactive glass powder:

[0049] First add 8 g of dodecylamine (DDA) to a mixed solution of 50 mL of deionized water and 160 mL of absolute ethanol, and then place it in a constant temperature water bath at 40°C for magnetic stirring until the dodecylamine is completely dissolved; Add 43.46 mL tetraethyl orthosilicate to the pump at a speed of 0.5 mL / min. During this process, due to the gradual formation of the Si network, the solution becomes turbid and becomes milky white; then add 4.4 mL triethyl phosphate at a speed of 0.5 mL / min with a syringe pump. ester; then dissolve 27.48 g of calcium nitrate tetrahydrate in 200 mL of deionized water, slowly add to the reaction solution, continue to stir for 3 h, and age at room temperature for 24 h; finally, centrifuge the glass sol to...

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Abstract

The invention discloses a hierarchical-pore-containing bioactive glass/polylactic acid-glycolic acid copolymer composite scaffold and a preparation method thereof. The hierarchical-pore-containing bioactive glass/polylactic acid-glycolic acid copolymer (PLGA) composite scaffold is prepared through the following steps that bioactive glass, camphene and polylactic acid-glycolic acid copolymer (PLGA)are added in an organic solvent 1,4-dioxane in a certain proportion in sequence, ultrasonic treatment, stirring and uniform dispersing are conduced, then the mixture is poured into a mold, freeze drying is conducted after pre-frozen forming. The scaffold is simple in preparation process, convenient to operate and stable in quality; by adding the bioactive glass, the mechanical property can be supplemented and improved, and the good biological activity and osteoinductive property are achieved; in addition, by adding camphene, can build a multistage connected hole structure similar to a naturalbone can be bionically constructed, and the scaffold has good application prospects in the fields of bone defect repair, bone tissue engineering and the like.

Description

technical field [0001] The invention belongs to the field of preparation of biomedical materials, and in particular relates to a bioactive glass / polylactic-co-glycolic acid (PLGA) composite bracket with a hierarchical pore structure and a preparation method thereof. Background technique [0002] At present, traditional autologous bone transplantation and allogeneic bone transplantation are commonly used in the clinical treatment of patients with bone defects. However, due to limited sources of autologous bone transplantation and insufficient donors, allogeneic bone grafts have shortcomings such as immune rejection and disease infection, which are difficult to satisfy patients. The demand for bone repair, so the clinical demand for bone tissue engineering scaffolds with repair function is becoming stronger and stronger, which also promotes the rapid development of bone repair scaffold research, and makes the research and development of bone repair materials become an internati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/46C08J9/28C08L67/04C08K3/40
Inventor 陈晓峰田婷陈雪颖史淼曾蕾
Owner SOUTH CHINA UNIV OF TECH
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