Ultrasonic real-time monitoring method of tumor photo-thermal treatment range

A photothermal therapy and real-time monitoring technology, applied in the medical field, can solve problems such as inability to directly measure, inability to effectively monitor temperature changes, and imperfect theory, so as to avoid iatrogenic injury.

A photothermal therapy and real-time monitoring technology, applied in the medical field, can solve problems such as inability to directly measure, inability to effectively monitor temperature changes, and imperfect theory, so as to avoid iatrogenic injury.

CN109770949AInactive Publication Date: 2019-05-21CHONGQING MEDICAL UNIVERSITY
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  • Ultrasonic real-time monitoring method of tumor photo-thermal treatment range
  • Ultrasonic real-time monitoring method of tumor photo-thermal treatment range
  • Ultrasonic real-time monitoring method of tumor photo-thermal treatment range

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Embodiment Construction

[0035] The following is further described in detail through specific implementation methods:

[0036] The specific operation and effect of monitoring the photothermal treatment of living organisms in the embodiment of the method of the present invention will be described below by taking isolated fresh pig liver as an example:

[0037] The changes of the hardness of the liver tissue with the temperature were detected and summarized, and the results were as follows: figure 1 As shown, it can be seen intuitively from the measured liver tissue temperature-hardness change curve that when the temperature is less than 50°C, the tissue hardness value is low and the tissue is soft; when the tissue temperature is greater than 70°C, the tissue hardness value is high and the tissue is hard; When the temperature is 50°C-70°C, the hardness of the tissue changes from soft to hard as the temperature rises. Therefore, the change of tissue hardness is selected as the monitoring object, combine...

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Abstract

The invention relates to the technical field of monitoring in tumor treatment, and discloses an ultrasonic real-time monitoring method of a tumor photo-thermal treatment range. The method includes thestep of monitoring and further includes the step of data quantifying and evaluating. In the step of monitoring, specifically, the tissue hardness of a focus region and surrounding normal tissue is monitored in real time through ultrasonic waves, and a two-dimensional tissue hardness distribution image is output in real time. In the step of data quantifying and evaluating, the output image is quantified and evaluated at intervals according to the two-dimensional tissue hardness distribution image output in real time, and the intensity and the range of photo-thermal treatment are recognized. The tissue hardness is used as a monitoring object, the hardness change of the focus region and the surrounding normal tissue is monitored in real time through the ultrasonic waves, the temperature andhardness change of lesion tissue and normal tissue is acquired, thus, the temperature and hardness change condition of the tissue can be found effectively in time, the power and the duration of near infrared light can be adjusted in time, and then the problem of iatrogenic injuries of the normal tissue is effectively avoided.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to an ultrasound real-time monitoring method for the photothermal treatment range of tumors. Background technique [0002] Photothermal therapy technology is a kind of thermal ablation therapy technology. Its working principle is to use materials with high photothermal conversion efficiency and inject them into the interior of organisms, and use targeted recognition technology to make materials in tumor tissue and It is concentrated near the tumor tissue, and under the irradiation of an external light source (usually near-infrared light), the light energy is converted into heat energy to kill tumor cells. In order to achieve the purpose of treatment, it is often necessary to raise the temperature of the treatment area to above 55°C during photothermal therapy to denature proteins to kill cancerous cells. During this process, the normal tissues around the diseased tissue often caus...

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Application Information

Patent Timeline
21 May 2019
Publication
CN109770949A
IPC
A61B8/08; A61N5/067
Inventors
张存程; 王志刚