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Six-arm polyethylene glycol amino hydrogel, its preparation method and application

A technology of polyethylene glycol amino and polyethylene glycol, which is applied in the field of preparation of new six-arm polyethylene glycol hydrogel, can solve the problems of slow response rate of hydrogel and limitation of hydrogel, and achieve external response Fast, low cost, strong in vitro mechanical properties and excellent results

Active Publication Date: 2021-11-09
湖南华腾医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hydrogels synthesized by traditional organic cross-linking methods have a slow response rate to external stimuli, which severely limits the practical application of hydrogels.

Method used

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  • Six-arm polyethylene glycol amino hydrogel, its preparation method and application
  • Six-arm polyethylene glycol amino hydrogel, its preparation method and application
  • Six-arm polyethylene glycol amino hydrogel, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Preparation of six-arm polyethylene glycol hydrogel

[0055] Using six-arm polyethylene glycol amino (n=30) as the raw material of six-arm polyethylene glycol and diethylenetriaminepentaacetic acid as the raw material of polycarboxy compounds, prepare six-arm polyethylene glycol amino hydrogel: weigh diethylene Triaminepentaacetic acid (3mmol), acetic anhydride (2mmol), uniformly mixed and stirred for 12 hours, added 8g six-arm polyethylene glycol amino (1mmol) to the mixture, and added N-methylmorpholine (0.4mmol) simultaneously and mixed Evenly, after stirring for 2 hours, let it stand at room temperature for 12 hours at 35°C. The obtained gel was soaked in ethanol for 1 hour, then the ethanol was filtered off with suction, and the ethanol was filtered off three times. After soaking in water for 1 hour, the suction filtration was repeated three times, and a colorless transparent hydrogel material was obtained.

Embodiment 2

[0057] Preparation of six-arm polyethylene glycol hydrogel

[0058] Using six-arm polyethylene glycol amino (n=10) as the raw material of six-arm polyethylene glycol and diethylenetriaminepentaacetic acid as the raw material of polycarboxy compound, prepare six-arm polyethylene glycol amino hydrogel: weigh diethylene Triaminepentaacetic acid (3mmol), acetic anhydride (3mmol), uniformly mixed and stirred for 12 hours, added 8g six-arm polyethylene glycol amino (1mmol) to the mixture, and simultaneously added pyridine (0.5mmol) and mixed uniformly, stirred for 2 hours Then stand at 45°C for 12h. The obtained gel was soaked in ethanol for 1 hour, then the ethanol was filtered off with suction, and the ethanol was filtered off three times. After soaking in water for 1 hour, the suction filtration was repeated three times, and a colorless transparent hydrogel material was obtained.

Embodiment 3

[0060] Preparation of six-arm polyethylene glycol hydrogel

[0061] Using six-arm polyethylene glycol amino (n=20) as the raw material of new six-arm polyethylene glycol and diethylenetriaminepentaacetic acid as the raw material of polycarboxy compound, prepare six-arm polyethylene glycol amino hydrogel: weigh two Ethylenetriaminepentaacetic acid (3mmol), acetic anhydride (2mmol), uniformly mixed and stirred for 12 hours, added 8g six-arm polyethylene glycol amino (1mmol) to the mixture, and simultaneously added triethylamine (0.1mmol) and mixed uniformly, After stirring for 2 hours, stand at 50°C for 12h. The obtained gel was soaked in ethanol for 1 hour, then the ethanol was filtered off with suction, and the ethanol was filtered off three times. After soaking in water for 1 hour, the suction filtration was repeated three times, and a colorless transparent hydrogel material was obtained.

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Abstract

The application relates to a six-arm polyethylene glycol amino hydrogel and a preparation method thereof. The method comprises the step of reacting raw materials obtained by uniformly mixing six-arm polyethylene glycol amino groups, polycarboxy compounds and acetic anhydride under the condition of the presence of a catalyst to form a gel. In the method, group-selective capped six-arm polyethylene glycol amino groups are used as raw materials, polycarboxy compounds are used as cross-linking agents, a network structure is formed by adding acetic anhydride, and one-step reaction is carried out at room temperature under catalyst conditions. The method is simple; the mechanical properties of the hydrogel can be adjusted by controlling the type and ratio of the polycarboxy compound and the chain length of the novel six-armed polyethylene glycol amino group.

Description

technical field [0001] The invention belongs to the field of organic polymer materials, and relates to a preparation method and application of a novel six-arm polyethylene glycol hydrogel with controllable mechanical properties. Background technique [0002] As a new type of functional polymer material, hydrogel has attracted the attention of more and more researchers due to its high water absorption, excellent biocompatibility and stimuli response ability, and has been widely used in biological tissue engineering, pharmaceuticals, etc. Controlled release, wastewater treatment, chemical mechanical devices, daily necessities and other fields. With the development of the industry and the advancement of science and technology, people have put forward more stringent requirements for the comprehensive performance of hydrogels. The research hotspots of scientists are mainly focused on improving the mechanical properties of hydrogels and increasing the response rate of hydrogels, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/24C08J3/075C08L71/02
Inventor 张安林邓泽平成佳赵春晖赵洁吴四清
Owner 湖南华腾医药有限公司
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