Application of rapamycin or its derivative as allergic disease drugs
A technology for allergic diseases and rapamycin, which is applied in the application field of rapamycin or its derivatives as drugs for the treatment of allergic diseases, and can solve problems such as obvious side effects, easy induction of infection, tumors, and low immune function of the body , achieve less side effects, alleviate allergic reactions, and achieve the effect of small effective dose
Inactive Publication Date: 2019-06-21
SHENZHEN INST OF ADVANCED TECH
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Problems solved by technology
Although this type of drug has a certain effect on the control of allergic diseases, it has obvious side effects due to its inhibitory effect on most immune cells. If used for a long time, it will lead to low immune function of the body and easily induce infections, tumors and other diseases
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[0026] In this example, mouse-derived ILC2 cells were treated with rapamycin in vitro, and then the level of type II cytokines produced by them was detected, and the level of eosinophils induced by them in vivo was detected. At the same time, an equal volume of DMSO solvent was used as a control. The ILC2 cells in this example were isolated from lymph nodes of mice according to conventional lymphocyte isolation methods. The details are as follows:
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The application discloses application of rapamycin or its derivative as an allergic disease drug. It is discovered via researches that rapamycin can evidently inhibit ILC2 and ICL2-mediated immune response II. The application provides a novel pharmaceutical use of rapamycin by research and development, namely the use as an allergic disease drug. When rapamycin or its pharmaceutically acceptable derivative is used as an allergic disease drug, rapamycin or its derivative requires less effective dose and causes fewer side reactions than existing allergic disease drugs, has a clear acting mechanism, can relieve allergic reaction with high specificity by targeting at ILC2 cells that play an important role in allergic immune reaction, and never causes nonspecific inhibitory action upon other immune cells.
Description
technical field [0001] The application relates to the field of drugs for treating allergic diseases, in particular to the application of rapamycin or its derivatives as drugs for treating allergic diseases. Background technique [0002] At present, the treatment of allergic diseases, such as allergic asthma, mainly uses broad-spectrum immunosuppressants of glucocorticoids. Although these drugs have a certain effect on the control of allergic diseases, they have obvious side effects due to their inhibitory effect on most immune cells. If used for a long time, they will lead to low immune function of the body and easily induce infections, tumors and other diseases. [0003] Rapamycin (also known as "sirolimus") is a secondary metabolite secreted by soil Streptomyces first discovered by scientists in the soil of Easter Island, Chile in 1975. Its chemical structure belongs to the "triene macrolide compounds. In 1977, it was discovered that rapamycin has an immunosuppressive ef...
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IPC IPC(8): A61K31/436A61P37/08
Inventor 万晓春郑超越毕嘉成
Owner SHENZHEN INST OF ADVANCED TECH