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Application of membrane separation technique in preparation of Xun Ma Zhen pills (urticaria pills)

A preparation process, a technology of urticaria, applied in the field of medicine, can solve problems such as environmental pollution, long production cycle, and difficult guarantee of product quality

Inactive Publication Date: 2019-06-21
刘森
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional process of water extraction and alcohol precipitation method has a long production cycle, low recovery rate of organic solvent, large energy consumption, repeated heating, serious loss of active ingredients, difficult product quality assurance, and easy to cause environmental pollution and other problems

Method used

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  • Application of membrane separation technique in preparation of Xun Ma Zhen pills (urticaria pills)
  • Application of membrane separation technique in preparation of Xun Ma Zhen pills (urticaria pills)
  • Application of membrane separation technique in preparation of Xun Ma Zhen pills (urticaria pills)

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 Urticaria extracts extraction liquid impurity-removing process optimization

[0015] 1. Instruments and reagents

[0016] 1.1 Instrument

[0017] Agilent 1200 high-performance liquid chromatography, USC-502 ultrasonic cleaning instrument (Shanghai Bolong Electronic Equipment Co., Ltd.), the pore diameters of the membrane tube materials are: PVDF microfiltration membrane: pore size 200 nm; PES ultrafiltration membrane: pore size 50 kd, 10 kd, 2.5kd; desktop electric drying oven (Tianjin Test Instrument Co., Ltd., China), membrane separation equipment (Jilin Haipu Technology Co., Ltd.), electronic constant temperature water bath box (Tianjin Test Instrument Co., Ltd., China), electronic balance (Beijing Sartorius Instrument System Co., Ltd.)

[0018] 1.2 Reagent

[0019] Reference substances of baicalin and paeoniflorin (China Institute for Food and Drug Control), acetonitrile and methanol (chromatographically pure, American Tiandi Company), water was doub...

Embodiment 2

[0064] A kind of application of membrane separation technology in the preparation technology of urticaria pill, comprises the following steps:

[0065] 1) Preparation of Urticaria Pill Extract

[0066] Angelica dahurica, Fangfeng, white fresh skin, mint, Chuanxiong, three needles, red peony, clematis, smilax, nepeta, flaxseed, skullcap, cohosh, flavescens, safflower, Polygonum multiflorum, Tribulus terrestris (stir-fried) , chrysanthemum, and angelica are made into coarse powder, and 70% ethanol solution is added to the coarse powder, extracted twice, each time for 2 hours, the extract is filtered and combined to obtain the extract of urticaria pills; The amount of the solution added is Angelica dahurica, Fangfeng, Baixianpi, mint, Chuanxiong, three needles, red peony, Clematis, Smilax, Nepeta, flaxseed, skullcap, cohosh, flavescens, safflower, Polygonum multiflorum, 15 times the total mass of Tribulus terrestris (stir-fried), chrysanthemum and angelica;

[0067] 2) filter ...

Embodiment 3

[0072] A kind of application of membrane separation technology in the preparation technology of urticaria pill, comprises the following steps:

[0073] 1) Preparation of Urticaria Pill Extract

[0074] Angelica dahurica, Fangfeng, white fresh skin, mint, Chuanxiong, three needles, red peony, clematis, smilax, nepeta, flaxseed, skullcap, cohosh, flavescens, safflower, Polygonum multiflorum, Tribulus terrestris (stir-fried) , chrysanthemum, and angelica are made into coarse powder, add 30% ethanol solution to the coarse powder, extract twice, each time for 2 hours, filter the extract, merge to obtain the extract of urticaria pills; The amount of the solution added is Angelica dahurica, Fangfeng, Baixianpi, mint, Chuanxiong, three needles, red peony, Clematis, Smilax, Nepeta, flaxseed, skullcap, cohosh, flavescens, safflower, Polygonum multiflorum, 5-15 times the total mass of Tribulus terrestris (stir-fried), chrysanthemum, and angelica;

[0075] 2) filter

[0076] The urtica...

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Abstract

The invention discloses application of a membrane separation technique in the preparation of Xun Ma Zhen pills (urticaria pills). The membrane separation technique is applied to the preparation of XunMa Zhen pills; the principle of different membrane components intercepting different molecular weights is utilized; through the combination of microfiltration and ultrafiltration, Xun Ma Zhen pills extract is cleaned by membrane filtration before membrane concentration is performed; the cleaning process is optimized, and stability of a preparation is guaranteed. Compared with the traditional water-extracting alcohol-precipitating technique, the membrane separation technique herein gains references to adapt to the Xun Ma Zhen pills extract cleaning process. Experimental results show that bothpaeoniflorin and baicalin transfer rates in the Xun Ma Zhen pills made via the membrane separation technique are higher than 80%; the contents of paeoniflorin and baicalin in the Xun Ma Zhen pills arefar higher than those provided by the traditional alcohol precipitation technique; the production cost can be reduced, treatment effect can be improved, and the traditional water-extracting alcohol-precipitating technique can be replaced.

Description

technical field [0001] The invention belongs to the field of medicine, relates to the technical field of urticarial pills, in particular to the application of a membrane separation technology in the preparation process of urticarial pills. Background technique [0002] The chemical composition of traditional Chinese medicine is very complex, and its molecular weight ranges from tens to millions of daltons. Based on the current research results, it is believed that the main effective substances of traditional Chinese medicines and compound prescriptions are small molecular substances with a relative molecular mass of only a few hundred to a few thousand Daltons, such as alkaloids, flavonoids, saponins, organic acids, etc. The filtrate obtained by using an ultrafiltration membrane with a certain molecular weight cut-off value is different from what is commonly referred to as the "effective part" now. It is a more complex system containing many types of components, which can be...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K36/90A61K9/20A61P17/00A61P37/08
Inventor 刘森刘晓青孟祥军
Owner 刘森
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