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Device for preparing coaxial multilayer hollow gel fiber pipe and using method and application thereof

A technology for hollow gel fiber tubes and preparation devices, which is applied in biochemical equipment and methods, tissue cell/virus culture devices, biochemical instruments, etc., and can solve the problems of complicated processes, difficult assembly of manufacturing devices, and difficulty in large-scale industrial production and manufacturing And other issues

Pending Publication Date: 2019-06-25
哈尔滨工大国际干细胞工程研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Hollow gel fiber tubes are also involved in the fields of textile, medicine, chemical industry, and environmental protection, but the assembly of the manufacturing device itself is already very difficult, and the preparation of coaxial multi-layer hollow gel fiber tubes through nested assembly will make the process more complicated. Complicated and difficult for large-scale industrial production

Method used

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  • Device for preparing coaxial multilayer hollow gel fiber pipe and using method and application thereof
  • Device for preparing coaxial multilayer hollow gel fiber pipe and using method and application thereof
  • Device for preparing coaxial multilayer hollow gel fiber pipe and using method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0028] Such as Figure 1 to Figure 4 As shown, the present invention provides a preparation device for a coaxial multilayer hollow gel fiber tube, comprising a T-shaped three-way pipe 1, and the T-shaped three-way pipe 1 is provided with a first open end 2 and a second open end 3 and a third open end 4, the first open end 2 is provided with a first first Luer female connector 5, the second open end 3 is provided with a second second Luer female connector 6, and the third open end 4 A Luer male connector 7 is provided, and an inner straight pipe 8 is arranged horizontally in the T-shaped tee pipe. The ratio of the outer diameter of the direct inner pipe to the inner diameter of the first open end is between 0.05 and 0.95, and the inner diameter The straight tube 8 is a circular tube structure with two ends open, one end of the inner straight tube 8 is fixed on the first Luer female connector 5, the third open end 4 is an arc-shaped structure 9, An opening is set on the arc str...

Embodiment 2

[0030] Get a T-shaped three-way pipe 1 (the ratio of the inner diameter of the inner straight pipe 8 to the inner diameter of the T-shaped three-way pipe 1 is 0.4), connect the first Luer female connector 5 to the ultrapure water input device, and connect the second Luer female connector 5 to the ultrapure water input device. The Luer female connector 6 is connected to the 2% sodium alginate glue input device, and the needle 10 with an inner diameter of the needle tube of 0.69 mm is connected to the Luer male connector 7 .

[0031] First pump ultrapure water into the T-shaped tee pipe 1 through the first Luer female connector 5, and then pump 2% sodium alginate glue into the T-shaped tee pipe 1 through the second Luer female connector 6 Under the push of the delivery pump, the T-shaped tee tube 1 forms a tubular structure with glue on the outside and ultrapure water in the center. It is squeezed into the Luer male connector 7 and the needle 10 through the arc structure 9, and i...

Embodiment 3

[0033] Get a T-shaped three-way pipe 1 (the ratio of the inner diameter of the inner straight pipe 8 to the inner diameter of the T-shaped three-way pipe 1 is 0.05), connect the first Luer female connector 5 with the ultrapure water input device, and connect the second The Luer female connector 6 is connected with the 1% sodium alginate glue input device, and the needle 10 with a needle inner diameter of 1.04 mm (No. 17) is connected with the Luer male connector 7 .

[0034] First pump ultrapure water into the T-shaped tee pipe 1 through the first Luer female connector 5, and then pump 1% sodium alginate glue into the T-shaped tee pipe 1 through the second Luer female connector 6 Under the push of the delivery pump, the T-shaped tee tube 1 forms a tubular structure with glue on the outside and ultrapure water in the center. It is squeezed into the Luer male connector 7 and the needle 10 through the arc structure 9, and is received by the needle 10. Further extrusion finally fo...

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Abstract

The invention provides a coaxial multi-layer hollow gel fiber pipe which comprises a T-shaped three-way pipe. The T-shaped three-way pipe is provided with three open ends, two open ends of the T-shaped three-way pipe are connected with a female luer connector, the other open end of the T-shaped three-way pipe is provided with a male luer connector, and an internal straight pipe is horizontally arranged in the T-shaped three-way pipe. The coaxial multi-layer hollow gel fiber pipe is manufactured step by step from inside to outside by using a special T-shaped tee joint with a luer joint. Finally, the coaxial multi-layer hollow gel fiber pipes with different outer diameters are prepared by replacing needle heads with the luer connectors, the coaxial multi-layer hollow gel fiber pipe can be conveniently prepared by the method, the coaxial multi-layer hollow gel fiber pipe is prepared by utilizing the fluidity of a glue solution, the problem is solved that the coaxial multi-layer hollow gelfiber pipe is manufactured by utilizing a glass capillary pipe at present, the method can be used in the fields of medicine, textile, chemical engineering and the like, and is suitable for large-scale production and manufacturing of stem cells based on the hollow gel fiber pipes.

Description

technical field [0001] The invention belongs to the technical field of functional materials and the fields of stem cell research, medicine, textile, chemical industry, and environmental protection, and specifically relates to a preparation device for a coaxial multi-layer hollow gel fiber tube and its use method and application. Background technique [0002] The use of hollow gel capsules or hollow gel fiber tubes for stem cell culture can transform the traditional 2D culture mode into 3D culture, which can effectively save production space and reduce production costs, which is of great significance for the large-scale application of stem cells. [0003] When using hollow gel fiber tubes for stem cell culture, it is generally necessary to nest and assemble glass capillaries of different diameters. The manufacturing process is very complicated, and sometimes it is necessary to prepare capillaries of different diameters for assembly through the glass needle drawing process. In...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00
Inventor 华子昂刘宝全竹添孙宁万君兴朱美瑛张建王娇李娜王秋燕
Owner 哈尔滨工大国际干细胞工程研究院有限公司