Xanthene organic compound and its preparation method and application
An organic compound, xanthene technology, applied in the field of xanthene organic compounds and their preparation, can solve the problems of different performance
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Embodiment 1
[0042] Embodiment 1: the synthesis of compound 1
[0043]
[0044] Under nitrogen atmosphere, 2-aminobenzophenone (19.7g, 100mmol) and NaOt-Bu (19.2g, 200mmol) were added to 200mL dry toluene and stirred for 20min, then bromobenzene (15.6g, 100mmol), Pd( OAc)2 (0.2g, 1mmol) and P(t-Bu) 3 (0.8g, 2mmol), heated to 80°C for 6h. After monitoring the reaction, cool to room temperature, add 300 mL of water to wash, separate layers, extract, and separate by silica gel column chromatography to obtain 4.58 g of compound C-1 with a yield of 90%.
[0045] Intermediate C-1 (24.58g, 90mmol) was dissolved in 300mL of anhydrous tetrahydrofuran, cooled to about 0°C, phenylmagnesium bromide solution (44mL, 110mmol) was added dropwise, and then raised to 40°C for 6h. After the reaction, cool to normal temperature, add 300mL water to wash, separate layers, extract with 300mL ethyl acetate, wash the obtained organic phase with saturated aqueous sodium bicarbonate solution, dry and separate b...
Embodiment 2
[0050] Embodiment 2: the synthesis of compound 2
[0051]
[0052] Compound 2 was prepared according to the method of compound 1 in Example 1. The difference is that the intermediate J-1 in Example 1 was replaced by intermediate J-2 (tetrabromobiphenyl), and the rest were the same to obtain compound 2 with a yield of 78%. ESI-MS (m / z) (M+): The theoretical value is 574.24, and the measured value is 574.54.
Embodiment 3
[0053] Embodiment 3: the synthesis of compound 10
[0054]
[0055] Compound 10 was prepared according to the method of compound 1 in Example 1. The difference is that intermediate J-1 in Example 1 was replaced by intermediate J-10 (3-bromo-9-phenylcarbazole), and the rest were the same to obtain compound 10 with a yield of 80%. ESI-MS (m / z) (M+): The theoretical value is 663.27, and the measured value is 663.74.
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