Diagnostic marker and equipment for detecting autism spectrum disorders, and application

A diagnostic marker and technology for autism, applied in the field of diagnostic markers for detection of autism spectrum disorders, can solve the problem of no specific therapeutic drugs or specific biodiagnostic markers for detection of autism spectrum disorders, and achieve enhanced objectivity Effect

Inactive Publication Date: 2019-06-28
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the deficiencies in the prior art above, the purpose of the present invention is to provide a diagnostic marker, device and application for detecting autism spec

Method used

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  • Diagnostic marker and equipment for detecting autism spectrum disorders, and application
  • Diagnostic marker and equipment for detecting autism spectrum disorders, and application
  • Diagnostic marker and equipment for detecting autism spectrum disorders, and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Seven differential proteins that were simultaneously changed in the plasma and peripheral blood mononuclear cells of ASD children 1 and healthy controls were obtained, as shown in Table 1 below. Among them, five proteins have the same expression trend in the two, that is, α-1-antitrypsin, complement protein C3, and vitronectin are all up-regulated in plasma and PBMCs cells; integrin α-IIb, thrombospondin-1 It was down-regulated in both plasma and PBMCs cells. The expression trends of the two proteins were opposite, that is, calmodulin and calreticulin were down-regulated in plasma, but up-regulated in PBMCs.

[0022] surface ASD children 1 and control plasma and peripheral blood mononuclear cells co-change differential proteins

[0023]

Embodiment 2

[0025] Three differential proteins that were simultaneously changed in the plasma and peripheral blood mononuclear cells of ASD children 2 and healthy controls were obtained, as shown in Table 2 below. Among them, one protein: α-1-antitrypsin was up-regulated in both plasma and PBMCs cells, and the expression trend was consistent in both; two proteins: calmodulin and calreticulin were down-regulated in plasma, and were down-regulated in plasma. It was up-regulated in PBMCs cells, and the expression trend was opposite in both.

[0026] Table 2 Differential proteins in ASD children 2 and control plasma and peripheral blood mononuclear cells

[0027]

Embodiment 3

[0029] Obtain 5 differential proteins that change simultaneously in plasma and peripheral blood mononuclear cells of ASD children 3 and healthy controls, as shown in Table 3 below. Three of them had the same expression trend in the two, namely: complement protein C3 and vitronectin were up-regulated in both plasma and PBMCs; integrin α-IIb was down-regulated in both plasma and PBMCs. The expression trends of the two proteins were opposite, that is, calmodulin and calreticulin were down-regulated in plasma, but up-regulated in PBMCs.

[0030] Table 3 Differential proteins in ASD children 3 and control plasma and peripheral blood mononuclear cells

[0031]

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Abstract

The invention discloses a diagnostic marker and equipment for detecting the autism spectrum disorders (ASD), and application. The diagnostic marker is one protein combination group that is formed by any three or more than three kinds of proteins including alpha-1-antitrypsin, calmodulin, calreticulin, complement protein C3, integrin alpha-Iib, thrombospondin-1, and vitronectin. According to the invention, the plasma and peripheral blood mononuclear cells protein marker that are used for ASD diagnosis are determined; and the ASD is diagnosed by detecting the expressions of the marker protein inthe plasma and the protein simultaneously, so that the objectivity, specificity and accuracy of diagnosis are enhanced; and since a few of protein types are detected, the detection efficiency is improved.

Description

technical field [0001] The invention relates to the technical field of reagent application, in particular to a diagnostic marker, equipment and application for detecting autism spectrum disorder. Background technique [0002] Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by social communication impairment, narrow range of interests or activities, and repetitive stereotyped behaviors. The prevalence rate of the disease is gradually increasing, seriously affecting the physical and mental health of infants and children, and bringing a heavy burden to families and society. Since the etiology and pathogenesis have not yet been elucidated, there are no specific therapeutic drugs and specific biodiagnostic markers. The current diagnosis of ASD is mainly based on scales, clinical symptoms, and the clinical experience of doctors, which can easily lead to delayed diagnosis or misdiagnosis. [0003] Practice has shown that early diagnosis a...

Claims

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Application Information

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IPC IPC(8): G01N33/53G01N33/535G01N33/68
Inventor 沈立明冯承芸赵丹青
Owner SHENZHEN UNIV
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