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Non-human primate stroke model development method

A primate, stroke technology, applied in the field of clinical scientific research, can solve problems such as long-term evaluation of inability to improve function

Inactive Publication Date: 2019-07-19
KUNMING BIOMED INT
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention provides a non-human primate stroke model research and development method, which solves the problem that the long-term evaluation of functional improvement cannot be performed

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  • Non-human primate stroke model development method
  • Non-human primate stroke model development method
  • Non-human primate stroke model development method

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Embodiment Construction

[0033] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0034] A non-human primate stroke model development method, comprising the following steps:

[0035] A1. Prepare experimental materials: 18gage needle, 5F arterial cannula, 4F arteriography catheter, 0.25mm arteriography micro guide wire, digital subtraction angiography (DSA) system, MRI system, MRI compatible ventilator, MRI compatible Physiological signal detection system.

[0036] A2. Preparation of experimental animals: five young and middle-aged cynomolgus monkeys, male,...

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Abstract

The invention relates to the technical field of a clinical scientific research, and discloses preparing experimental materials: a 18gage needle, a 5F arterial cannula, a 4F angiography catheter, a 0.25mm angiography micro-guidewire, a digital subtraction angiography (DSA) system, a MRI System, a nuclear magnetic resonance compatible respirator, a nuclear magnetic resonance compatible physiologicalsignal detection system. The development method is characterized in that a stable cerebral ischemia-reperfusion animal model of cynomolgus monkey is accurately prepared by intravascular coil embolization, the infarct size of the experimental animal is moderate and no hemorrhagic transformation in the infarct area is generated after reperfusion, the animal can survive for a long time, has the corresponding symptoms of neurological deficit, and the stability of the model is proved through long-term imaging and behavioral evaluation. The method can accurately control the location and extent of stroke, and the experimental animals are able to maintain stable clinical symptoms, so the model is suitable for the assessment of the safety and efficacy of new therapy and new drugs for stroke.

Description

technical field [0001] The invention relates to the technical field of clinical scientific research, in particular to a method for developing a non-human primate stroke model. Background technique [0002] Stroke has become the second most common cause of death in the world, and the death and disability caused by it have brought a heavy economic burden to the world. According to the analysis of the global stroke profile in 2014, the incidence of stroke ranks first in the world, and the death rate ranks second in the world , about 3 / 4 of stroke patients will have sequelae of varying degrees, and ischemic stroke accounts for about 60.3-80.5% of stroke. [0003] Since non-human primates are highly similar to the human nervous system in terms of anatomical structure, development and function, it is necessary to use monkey stroke models to carry out stroke treatment research in order to realize the transformation from more mature rodent models to unknown human clinical applicatio...

Claims

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Application Information

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IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 杨立川
Owner KUNMING BIOMED INT
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