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Tilmicosin mixed micelle soluble powder and preparation method thereof

A technology of tilmicosin and mixed micelles, which is applied in powder delivery, pharmaceutical formulations, organic active ingredients, etc., can solve the problems of causing negative cardiac effects, affecting the use of tilmicosin, and difficulty in taking animals, so as to reduce the Water consumption, bioavailability improvement, fast dissolution effect

Inactive Publication Date: 2019-07-19
安徽奥力欣生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, intravenous injection of tilmicosin is prohibited. A single intravenous injection of 5 mg / kg can kill cattle, and it is also easy to kill pigs, horses and primates. The target organ of its toxic effect is the heart, which can cause negative cardiodynamic effects.
Moreover, because tilmicosin tastes extremely bitter and stimulates the gastrointestinal tract, it will cause symptoms such as anorexia, nausea and vomiting in livestock and poultry. It is quite difficult for animals to take it, which seriously affects the use of tilmicosin

Method used

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  • Tilmicosin mixed micelle soluble powder and preparation method thereof

Examples

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Effect test

Embodiment 1

[0034] Embodiment 1 A kind of tilmicosin mixed micelle soluble powder is made by the raw material of following weight (g): tilmicosin 10, sodium glycocholate 20, soybean lecithin 40, anhydrous glucose 30,

[0035] The preparation method of tilmicosin mixed micelle soluble powder comprises the following steps:

[0036] 1) Weigh each component raw material according to the formula ratio;

[0037] 2) Add anhydrous ethanol twice the weight of tilmicosin to the weighed sodium glycinate cholate, soybean lecithin, and tilmicosin, stir thoroughly and heat to 40°C, and stir again when all the raw and auxiliary materials are dissolved 60 minutes, requiring that the phosphatidylcholine content in the soybean lecithin used should be greater than 50%;

[0038] 3) Transfer the above solution to the rotary evaporating bottle of the rotary evaporator, and carry out rotary evaporation, and the temperature of the water bath is required to be 45°C;

[0039] 4) When the medicine in the rotary e...

Embodiment 2

[0044] A kind of tilmicosin mixed micelle soluble powder is made from the following weight (g): tilmicosin 20, sodium glycocholate 30, soybean lecithin 50, anhydrous glucose 20,

[0045] Using the same preparation method as in Example 1, tilmicosin mixed micellar soluble powder was obtained.

Embodiment 3

[0047] A kind of tilmicosin mixed micelle soluble powder is made from the raw materials of following weight (g): tilmicosin 30, sodium glycocholate 40, soybean lecithin 30, sorbitol 10,

[0048] Using the same preparation method as in Example 1, tilmicosin mixed micellar soluble powder was obtained.

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Abstract

The present invention discloses tilmicosin mixed micelle soluble powder. The tilmicosin mixed micelle soluble powder is prepared from the following raw and accessory materials in parts by weight: 10-30 parts of tilmicosin, 20-40 parts of sodium glycocholate, 30-50 parts of soybean phospholipids and 10-30 parts of anhydrous glucose. The present invention also discloses a preparation method of the tilmicosin mixed micelle soluble powder. The tilmicosin mixed micelle soluble powder increases palatability under actions of the mixed micelle formed by the sodium glycocholate and soybean phospholipids, at the same time increases bioavailability of the tilmicosin, greatly improves drug stability, also reduces stimulation to the stomach, and thus effectively ensures feed intake of the medicine by diseased animals. The preparation method is simple and high in safety.

Description

[0001] Technical field: [0002] The invention relates to the field of medicaments for livestock and poultry, in particular to a tilmicosin mixed micelle soluble powder and a preparation method thereof. [0003] Background technique: [0004] As a major discovery in the development of human science and technology, antibiotics are a milestone in the fields of biology and medicine. Since the advent of penicillin in 1940, various synthetic and semi-synthetic antibiotics have emerged one after another, becoming an important weapon to protect the health of humans, animals and plants. The research and application of antibiotics are becoming more and more extensive, and they have played an important role in the prevention and control of animal diseases, improving feed utilization, and promoting the growth of livestock and poultry. [0005] Timicosin is a semi-synthetic macrolide antibiotic for livestock and poultry developed in the 1980s, with a molecular weight of 869.15. Tylosin i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K9/14A61K47/28A61K47/24A61K31/706A61P31/04
CPCA61K9/1075A61K9/145A61K31/706A61K47/24A61K47/28A61P31/04
Inventor 丁国平
Owner 安徽奥力欣生物科技有限公司
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