Industrial method for producing high-quality silymarin

Abstract

The invention relates to an industrial method for producing high-quality silymarin. The industrial method is characterized by comprising the following steps: (a), extracting by using acetone, namely synchronously extracting silybum marianum oil and silymarin from silybum marianum shells by using the acetone to obtain an acetone extraction solution; (b), separating the silybum marianum oil from thesilymarin, namely concentrating the acetone extraction solution in the step (a) till the concentration of the acetone is 35-45% to obtain the precipitated silybum marianum oil and a silymarin-containing acetone concentrate; (c), purifying by using methanol, namely adding the methanol into the acetone concentrate for washing out impurities. By the industrial method, automatic separation of the silybum marianum oil and the silymarin can be achieved, a complicated technology of separating the silybum marianum oil from the silymarin in the prior art is omitted, a production technology is simplified and the production cost is reduced. An obtained final product has the final moisture content being lower than 5%, the silymarin product content being 85-95% and the silybin content being higher than 85%.

Description

[0001] Technical field [0002] The invention relates to an industrial method for preparing natural extracts, in particular to an industrial method for producing high-quality silymarin. Background technique [0003] Silymarin is a mixture extracted from milk thistle seeds, and silybin is its main active ingredient, which has the effect of protecting the liver. [0004] Silymarin mainly exists in the shell of milk thistle seeds. After the shells and kernels of milk thistle seeds are separated, extracting silymarin from milk thistle shells can effectively reduce the difficulty of separating silymarin, thereby simplifying the process. The milk thistle shell needs to be pretreated to improve the extraction yield. The tableting process can destroy the cell structure to a certain extent, which is more conducive to the contact between the extraction solvent and the cell content. In the patent publication No. CN105503843A, the water fly Thistle seed coats are hydrolyzed with compound...

AI Technical Summary

Problems solved by technology

In terms of purification, in the patent with the publication number CN107098892A, after the extract is concentrated, methanol is added to dissolve and recrystallize for 48-72 hours. The amount of methanol is large, the crystallization time is too long, and the efficiency is low

In the patent with the publication number CN107805245A, silica gel column chromatography and chloroform-methanol gradient elution can be used to prepare products with a purity of more than 99%, but the production efficiency is low and the output is small, so it is not suitable for industrial production

[0005] In a word, in the preparation method of high-purity silymarin, whether it is extracting milk thistle seeds after squeezing or using organic solvents to remove oil, the process is lengthy, time-consuming, complex and inevitably leads to large losses, and it is difficult to guarantee the purity and yield of the product

The refining process continues to use methods such as crystallization, recrystallization, and chromatographic separation, and it is difficult to guarantee the smooth realization of industrialization in terms of cost and efficiency.

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