Biosafety laboratory chemical shower room pressure adjusting method and system

Abstract

The invention discloses a biosafety laboratory chemical shower room pressure adjusting system and method. a high-grade biosafety laboratory is a special laboratory for research on intensive pathogen prevention and treatment, strict negative pressure requirements and directional airflow control of a core area of the laboratory are important technical measures for guaranteeing biosafety, an experimenter wearing the protective clothing needs to pass through a chemical shower room, and chemical liquid medicine in the chemical shower room is sprayed to disinfect the surface of the protective clothing in and out of the chemical shower room, so that negative pressure control of the chemical shower room is seriously influenced by the obvious airflow interference in the chemical shower room: a doorof the chemical shower room is opened and closed; personnel protective clothing is used for breathing, supplying air and discharging; chemical shower liquid is sprayed; 1-3 persons entering the chemical shower room are not fixed; and the instability of a valve characteristic curve is regulated and controlled. Complex airflow interference conditions and related influence factors of the chemical shower room enable a negative pressure regulation scheme of the chemical shower room to face a severe challenge.

Description

technical field [0001] The invention relates to the technical field of pressure regulation, in particular to a method and system for regulating the pressure of a chemical shower in a biosafety laboratory aimed at negative pressure regulation in a chemical shower in a high-level biosafety laboratory. Background technique [0002] Wuhan National Biosafety Laboratory is the first high-level biosafety (Level 4) laboratory in my country. The high-level biosafety laboratory is a special laboratory for research on the prevention and control of severe pathogens. The core area of ​​the laboratory has strict negative pressure requirements and directional airflow Control is an important technical measure to ensure biological safety. Personnel entering and leaving the laboratory need to be disinfected and sterilized by spraying chemical liquid in the chemical shower room. The space in the chemical shower room is small, and the complex airflow interference conditions in the chemical shower...

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Problems solved by technology

[0002] Wuhan National Biosafety Laboratory is the first high-level biosafety (Level 4) laboratory in my country. The high-level biosafety laboratory is a special laboratory for research on the prevention and control of severe pathogens. The core area of ​​the laboratory has strict negative pressure requirements and directional airflow Control is an important technical measure to ensure biological safety. Personnel entering and leaving the laboratory need to be disinfected and sterilized by spraying chemical liquid in the chemical shower room. The space in the chemical shower room is small, and the complex airflow interference conditions in the chemical shower room and related multiple influencing factors make Negative pressure regulation in chemical showers faces serious challenges

[0003] Previously, in my country's P3 laboratory, biological safety cabinets, fume hoods and animal cage ventilation control have encountered similar control problems, but the interference factors are relatively single, and the occurrence space is relatively large. Through simple prediction or The feedback control of the operation signal of the equipment can basically solve the problem. At present, the Venturi valve is generally used for feedback control.

[0004] In view of the multiple and complex interference factors, the relatively high requirements for negative pressure control, the small space of the negative pressure control room, and the high requirements for system airtightness, the negative pressure control of chemical showers in high-level biosafety laboratories is somewhat challenging.

[0005] The existing problem is: when the chemical shower is isolated from the positive pressure changing room and the biosafety laboratory, negative pressure must be maintained, and the negative pressure gradient between the biosafety laboratory, the chemical shower, and the positive pressure changing room is -90pa , -75pa, -50pa, 0pa; the biosafety laboratory is a place used for severe virus or bacterial experiments. When entering the biosafety laboratory from the chemical shower or entering the chemical shower from the biosafety laboratory, the staff must pay attention to the chemical Clean and disinfect the shower room with chemical agents. When disinfecting the chemical shower room, spray compressed air at 30L / min and spray liquid medicine at 15L / min. In order to maintain the relative pressure in the chemical shower room, it is necessary to increase the opening value of the exhaust valve and improve the pumping rate. Gas volume; when entering the chemical shower room, the personnel need to supply air for the protective clothing to breathe, and the gas supply in the chemical shower room should be increased by 60m 3 / h*3 people breathe gas, in order to maintain the relative pressure of the chemical shower room, it is necessary to increase the opening value of the exhaust valve and increase the pumping volume; when the isolation between the biosafety laboratory, the chemical shower room and the positive pressure changing room When the door is opened and then closed, the pressure difference between the chemical shower room and the positive pressure changing room decreases first, and the opening of the regulating valve decreases, and then maintains a greater negative pressure to recover quickly, which is prone to positive pressure, or biosafety experiments. Compared with the chemical shower room, the pressure difference decreases first, the speed of the large exhaust fan increases, and the opening of the pressure regulating valve in the chemical shower room decreases. After being isolated from the biosafety laboratory, it is difficult to open the large pressure regulating valve immediately. Positive pressure is easily generated in the locker room instantly, resulting in the failure of biosafety isolation

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