Traditional Chinese medicine decoction pieces and preparation method thereof

A technology for Chinese herbal decoction pieces and traditional Chinese medicine, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as unfavorable subsequent utilization of Chinese herbal medicine decoction pieces, easy occurrence of moth-eaten, mildew, etc. Preservation quality, non-perishable effect

Inactive Publication Date: 2019-08-09

亳州市汇仁堂医药科技有限公司

3 Cites 1 Cited by

AI-Extracted Technical Summary

Problems solved by technology

In the prior art, Chinese herbal medicines are processed, then dried and packaged for storage. In the process of storage,...

Method used

First medicine intermediate product is placed in dry heat environment and carry out pre-sterilization, can promote the temperature of drug intermediate product, stay 30-40min under dry heat environment simultaneously, can make the part bacterium of drug intermediate product or fungus directly in It is killed in a dry heat environment, which reduces the operation time of subsequent sterilization.

The application adopts to carry out dry heat pre-sterilization earlier, then carry out microwave intermittent sterilization under dry h...

Abstract

The invention relates to the field of preparation of traditional Chinese medicine materials, and provides traditional Chinese medicine decoction pieces and a preparation method thereof. The preparation process of the traditional Chinese medicine decoction pieces comprises the steps that traditional Chinese medicine raw materials are processed and dried to obtain a pharmaceutical intermediate product, the pharmaceutical intermediate product is sterilized and then packaged. The traditional Chinese medicine decoction pieces are prepared by adopting the preparation process of the traditional Chinese medicine decoction pieces. The traditional Chinese medicine decoction pieces and the preparation method thereof have the advantages that the pharmaceutical intermediate product is sterilized afterdrying and before packaging, and bacteria and fungi in the traditional Chinese medicine decoction pieces can be killed, thereby prolonging the preservation time of the traditional Chinese medicine decoction pieces and improving the preservation quality of the traditional Chinese medicine decoction pieces, so that the traditional Chinese medicine decoction pieces do not rot and mildew easily, and the product quality is good.

Application Domain

HeatChemicals +2

Technology Topic

Traditional Chinese medicineMedicine +3

Examples

Experimental program(3)
Comparison scheme(10)
Effect test(1)

Example Embodiment

[0011] The embodiment of the present invention provides a preparation process of decoction pieces of traditional Chinese medicine, which includes: processing and drying the raw materials of traditional Chinese medicine to obtain intermediate medicines, sterilizing the intermediate medicines, and then packaging.

[0012] Among them, the method and process of processing and drying the raw materials of Chinese medicine are the prior art, and also refer to the existing processing and drying methods, which will not be described in detail in this application. Similarly, packaging products is also a routine operation, and this application will not elaborate on it.

[0013] Sterilizing the intermediate drug includes microwave drying and sterilizing the intermediate drug in a dry heat environment of 100-130°C.

[0014] Specifically, before microwave drying and sterilization, the drug intermediate product is placed in a dry heat environment for 30-40 minutes for pre-sterilization, and then placed in a dry heat environment for microwave drying and sterilization.

[0015] Put the intermediate drug product in a dry heat environment for pre-sterilization, which can increase the temperature of the drug intermediate product, and at the same time stay in the dry heat environment for 30-40 minutes, so that some bacteria or fungi of the drug intermediate product can be directly exposed to the dry heat environment The lower part is killed, reducing the operation time of subsequent sterilization.

[0016] In this application, the frequency of microwave drying and sterilization is 3.0×10 2 ~3.0×10 5 MHz, sterilization time is 1-2min. Further, the microwave drying and sterilization is performed multiple times, with an interval of 1-2 min between each time. That is, after performing a microwave drying and sterilization, stop for 1-2 minutes, and then perform microwave drying and sterilization. Intermittent operation can make the intermediate drug product in microwave drying. Microwave sterilization is the combined effect of microwave heat and biological effects. the result of. Thermal effect of microwave energy: Under the action of a certain intensity of microwave field, insects and bacteria in food will absorb microwave energy to heat up due to molecular polarization, thereby denaturing their protein and losing biological activity. The thermal effect of microwave is mainly for rapid heating and sterilization; the non-thermal effect of microwave energy: the high-frequency electric field also changes the membrane potential and polar molecular structure, causing the protein and physiologically active substances in the microorganism to mutate and lose vitality or death.

[0017] After microwave drying and sterilization, reduce the temperature of the dry heat environment to 30-40°C, and then pass ozone for ozone sterilization. Preferably, the cooling rate of the dry heat environment is 5-10°C/min. The concentration of ozone is 20-30g/m 3 , Ozone sterilization time is 10-20min, and the purity of ozone is 50-60%. In the ozone sterilization process, the heating in the dry heat environment is stopped and natural cooling is performed.

[0018] After microwave drying, ozone is used for further sterilization operations. Ozone can react with the double bonds of bacterial cell wall lipids, penetrate into the bacteria, act on proteins and lipopolysaccharides, change the permeability of cells, and cause the death of bacteria. Ozone also acts on nuclear substances in cells, such as purines and pyrimidines in nucleic acids, which destroy DNA. Ozone first acts on the cell membrane, causing damage to the components of the membrane, leading to metabolic disorders. Ozone continues to penetrate through the membrane, destroying lipoproteins and lipopolysaccharides in the membrane, changing the permeability of cells, and leading to cell lysis and death.

[0019] This application uses dry heat pre-sterilization first, then microwave intermittent sterilization in a dry heat environment, and then reduces the temperature of dry heat sterilization and then performs ozone sterilization, and during the ozone sterilization process, the dry heat environment is stopped The heating and natural cooling. The sterilization combination method of the present application has a good sterilization effect on the traditional Chinese medicine decoction pieces, can significantly improve the storage time and preservation quality of the traditional Chinese medicine decoction pieces, and effectively avoid the phenomenon of moth-eaten or mildew.

[0020] In addition, the present application also provides a Chinese medicine decoction piece, which is prepared by the above-mentioned preparation process of the Chinese medicine decoction piece. Its storage time is long, the product quality is good, and it is not easy to deteriorate and mold.

Example Embodiment

[0022] Example 1

[0023] This embodiment provides a traditional Chinese medicine decoction piece, and its preparation method includes the following steps:

[0024] 1. Selection: First, select Chinese medicinal materials to remove impurities, non-medicinal parts and those that have deteriorated and failed;

[0025] 2. Washing and moisturizing: Rinse the selected Chinese medicinal materials to remove fishy, salty, toxic or medicinal materials that need to be soaked thoroughly. Rinse until there is no or slightly fishy or salty taste, without white hearts or poisonous materials. Slightly spicy, without mildew, rot, or rancidity. Then rinse the herbs with water.

[0026] 3. Processing: slice the Chinese medicinal materials to 0.1-0.5mm.

[0027] 4. Drying: Use a drying oven to dry the processed pieces at a temperature of 70°C.

[0028] 5. Sterilization: first place the intermediate drug product in a dry heat environment of 110°C for 30 minutes for pre-sterilization, then continue to place it in a dry heat environment, and perform microwave drying and sterilization 2 times, with an interval of 1 minute each time, each time microwave The frequency of dry sterilization is 3.0×10 2 MHz, the sterilization time is 1 min. After microwave drying and sterilization, the temperature of the dry heat environment was lowered to 40°C at a temperature drop rate of 5°C/min, and then ozone was passed through for ozone sterilization. The concentration of ozone is 25g/m 3 , Ozone sterilization time is 15min, and the purity of ozone is 55%. In the ozone sterilization process, the heating in the dry heat environment is stopped and natural cooling is performed.

[0029] 6. Packaging: The packaging of Chinese herbal medicine should meet the requirements for medicinal use. The packaging (carton) or label of Chinese herbal medicine should indicate the name, address, telephone number, processing specifications adopted, production license number, net weight, production date, and production batch number of the manufacturer, and the outer packaging box should be marked with moisture-proof and moisture-proof Warning signs such as heat and anti-pressure.

Example Embodiment

[0030] Example 2-5

[0031] The preparation method of the traditional Chinese medicine pieces provided in Example 2-5 is roughly the same as that in Example 1, except that the parameters of the sterilization step are different:

[0032] Sterilization in Example 2: First place the drug intermediate product in a dry heat environment at 100°C for 40 minutes for pre-sterilization, then continue to place it in a dry heat environment, and perform microwave drying and sterilization 3 times with an interval of 1 minute each time. The frequency of each microwave drying and sterilization is 3.0×10 3 MHz, the sterilization time is 1 min. After microwave drying and sterilization, the temperature of the dry heat environment is lowered to 30°C at a cooling rate of 10°C/min, and then ozone is passed through for ozone sterilization. The concentration of ozone is 20g/m 3 , Ozone sterilization time is 10min, and the purity of ozone is 50%. In the ozone sterilization process, the heating in the dry heat environment is stopped and natural cooling is performed.

[0033] Sterilization in Example 3: First place the drug intermediate product in a dry heat environment of 130°C for 30 minutes for pre-sterilization, then continue to place it in a dry heat environment, and perform microwave drying and sterilization twice with an interval of 2 minutes. The frequency of each microwave drying and sterilization is 3.0×10 5 MHz, sterilization time is 2min. After microwave drying and sterilization, the temperature of the dry heat environment was lowered to 33°C at a cooling rate of 8°C/min, and then ozone was passed through for ozone sterilization. The concentration of ozone is 30g/m 3 , Ozone sterilization time is 20min, and the purity of ozone is 60%. In the ozone sterilization process, the heating in the dry heat environment is stopped and natural cooling is performed.

[0034] Sterilization in Example 4: First place the drug intermediate product in a dry heat environment of 120°C for 35 minutes for pre-sterilization, then continue to place it in a dry heat environment, and perform microwave drying and sterilization twice, with an interval of 2 minutes each time. The frequency of each microwave drying and sterilization is 3.0×10 4 , Sterilization time is 1min. After the microwave drying and sterilization, the temperature of the dry heat environment was lowered to 32°C at a cooling rate of 6°C/min, and then ozone was passed through for ozone sterilization. The concentration of ozone is 23g/m 3 , Ozone sterilization time is 13min, and the purity of ozone is 58%. In the ozone sterilization process, the heating in the dry heat environment is stopped and natural cooling is performed.

[0035] Sterilization in Example 5: first place the drug intermediate product in a dry heat environment of 125°C for 37 minutes for pre-sterilization, then continue to place it in a dry heat environment, and perform microwave drying and sterilization 3 times with an interval of 1 minute each time. The frequency of each microwave drying and sterilization is 3.0×10 2 MHz, sterilization time is 2min. After microwave drying and sterilization, the temperature of the dry heat environment was lowered to 36°C at a cooling rate of 9°C/min, and then ozone was passed through for ozone sterilization. The concentration of ozone is 28g/m 3 , Ozone sterilization time is 18 minutes, and the purity of ozone is 51%. In the ozone sterilization process, the heating in the dry heat environment is stopped and natural cooling is performed.

[0036] Comparative Experiment

[0037] One, the choice of sterilization process

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Description & Claims & Application Information

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Classification and recommendation of technical efficacy words

Improve preservation quality
Extend storage time

Rare product storage and display microenvironment maintaining system and method based on rare product somatosensory temperature

PendingCN111610811AImprove stabilityImprove preservation quality

Owner:CHINA RAILWAY CONSTR GROUP

Component detection kit applied to chemical drugs

PendingCN112875047AImprove sealingImprove preservation quality

Owner:LIAONING INST OF SCI & TECH

Traditional Chinese medicine decoction pieces and preparation method thereof

AI-Extracted Technical Summary

Problems solved by technology

Method used

Abstract

Examples

Example Embodiment

Example Embodiment

Example Embodiment

PUM

Description & Claims & Application Information

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