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Application of long-chain non-coding RNA NONHSAG039951.2 as diagnostic marker for osteoporosis

A technique of RNANONHSAG039951.2 and lncrnanonhsag039951.2, which is applied in the determination/inspection of microorganisms, biochemical equipment and methods, etc.

Pending Publication Date: 2019-08-09
SHENZHEN PEOPLES HOSPITAL +1
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Problems solved by technology

However, there are few reports on the expression profile characteristics and biological functions of osteoporosis LncRNA at home and abroad.

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  • Application of long-chain non-coding RNA NONHSAG039951.2 as diagnostic marker for osteoporosis
  • Application of long-chain non-coding RNA NONHSAG039951.2 as diagnostic marker for osteoporosis
  • Application of long-chain non-coding RNA NONHSAG039951.2 as diagnostic marker for osteoporosis

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Embodiment Construction

[0019] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. The following examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0020] Application of long-chain non-coding RNA NONHSAG039951.2 as a diagnostic marker for osteoporosis: find lncRNAs related to osteoporosis and predict their functions. In osteoporosis, the expression levels of some specific lncRNAs will change, This change in expression level can be used as a marker for osteoporosis screening. By finding the coding gene that is co-expressed and differentially expressed with the changed LncRNA, the function of the LncRNA can be speculated. Specifically, the present invention proceeds in three stages:

[0021] Phase 1, collecting samples and high-throughput sequencing;

[0022] The second stage, data filtering, sample quantification, calculation of differential expression...

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Abstract

The invention discloses application of long-chain non-coding RNA NONHSAG039951.2 as a diagnostic marker for osteoporosis. Through detection, it is found that the LncRNA NONHSAG039951.2 is expressed inbone tissue of both osteoporosis patients and normal persons, the expression level of the LncRNA NONHSAG039951.2 in the bone tissue of the osteoporosis patients is significantly higher than that of the normal persons, the difference has statistical significance, and it is suggested that the LncRNA NONHSAG039951.2 as the diagnostic marker for the osteoporosis has feasibility and clinical application value. The long-chain non-coding RNA NONHSAG039951.2 can be used as the diagnostic marker for the osteoporosis and achieves the purposes of early diagnosis and early treatment of the osteoporosis.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to the application of a long-chain non-coding RNA NONHSAG039951.2 as a diagnostic marker for osteoporosis. Background technique [0002] Osteoporosis is a complex, multifactorial systemic chronic skeletal disease characterized by decreased bone mass and destruction of bone microarchitecture, leading to increased bone fragility and susceptibility to fracture. With the aggravation of the aging phenomenon in our country, the incidence of osteoporosis has increased year by year, which has brought pain and harm to patients such as bone pain, fractures, and short height, and also brought heavy economic losses to society and families. and living burdens. [0003] The early onset of osteoporosis is hidden and the clinical manifestations are not typical. It can only be discovered by imaging examination and auxiliary serum / urine biochemical index examination, and there are certain limit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/178C12Q2600/158
Inventor 镇万新彭松林徐凤萍陈艳王尚杨玲张晨茜
Owner SHENZHEN PEOPLES HOSPITAL
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