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Preparation method and application of paeonol ferulate
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The technology of acid paeonol and paeonol is applied in the field of preparation of ferulic acid paeonol ester, which can solve the problem of equipment post-treatment, high anti-corrosion requirements, poor fat solubility of ferulic acid, and influence on the effect of ferulic acid. and other problems, to achieve the effect of improving anti-stress ability and immunity, low requirements for response equipment, and enhanced biological activity
Active Publication Date: 2022-06-21
YANGTZE RIVER FISHERIES RES INST CHINESE ACAD OF FISHERY SCI
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However, the fat solubility of ferulic acid is poor, and it is difficult to penetrate the lipid bilayer of biomembrane, which affects the effect of ferulic acid on aquatic products.
Modify the structure of ferulic acid to obtain ferulic acid derivatives, which is beneficial to the play of its effect, but the yield of the preparation of ferulic acid derivatives is generally not high, mostly 60-70%, and the used Most of the reagents are chloroform, thionyl chloride, sodium hydroxide and other highly toxic or corrosive reagents, which are easy to pollute the production environment and have high requirements for equipment post-processing and anti-corrosion
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Embodiment 1
[0031] Add 16.6g paeonol, 23.6g acetyl ferulic acid, 31.8g propyl phosphoric anhydride into the reactor, then add 60 mL of N,N-dimethylformamide, stir at room temperature for 8 hours, add a large amount of water, and filter with suction , drying to obtain the target product; after nuclear magnetic detection, the specific detection results are: 1 H NMR (CHCl 3 ,TMS,300MHz):δ=2.34(s,3H),2.53(s,3H), 3.87-3.89(d,J=6.0Hz,6H),6.62~6.70(m,2H),6.85~6.88(m , 1H), 7.08~7.21 (m, 3H), 7.84~7.90 (m, 2H), it is confirmed that the product obtained in this step of the present invention is acetoferulic acid paeonol ester.
Embodiment 2
[0033] 16.6g paeonol, 19.4g ferulic acid, and 31.8g propyl phosphoric anhydride were added to the reactor, and then 60 mL of N,N-dimethylformamide was added, stirred at room temperature for 8 hours, added a large amount of water, filtered with suction, The target product is obtained by drying; after nuclear magnetic detection, the specific detection results are: 1 H NMR (CHCl 3 ,TMS,300MHz):δ=2.52(d,J=3.0Hz,3H),3.86(d,J=3.0Hz,3H),3.93(s,3H),6.53(d,J=12.0Hz,1H) ,6.68(m,1H),6.86(m,1H),6.99(m,1H),7.09(m,1H),7.26(m,1H),7.80~7.88(m,2H),9.55(s,1H ), confirming that the product obtained in this step of the present invention is paeonol ferulate.
[0034] In the application effect test, in the following test process, the feed ratio of acetyl ferulic acid paeonol ester / ferulic acid paeonol ester is 200mg / kg, and the premix must be gradually expanded into the base material.
[0035] (1) Application effect in tilapia feed
[0036] The same equivalent of ferulic acid, ferulic acid + ...
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Abstract
The invention discloses a preparation method of paeonol ferulic acid, which comprises the steps of: adding paeonol, ferulic acid or acetyl ferulic acid, and propyl phosphoric anhydride into a reactor, and using N,N-dimethyl Use methyl formamide as solvent, stir at room temperature for 8 hours, add a large amount of water, and filter to obtain the target product. Also provided is the application of the prepared paeonol ferulate in feed and other fields. The present invention uses paeonol to modify the structure of ferulic acid to improve the fat solubility and biological activity of ferulic acid. The reagent used in the preparation method of the present invention has low toxicity, fast reaction speed, high reaction efficiency and good repeatability. The equipment requirement is low, the method is simple, the operation is easy, and the yield can reach 85-90%.
Description
technical field [0001] The invention relates to the technical field of ester synthesis methods, in particular to a preparation method of paeonol ferulate and its application in food, medicine, health care products, cosmetics and the like. Background technique [0002] Fish and shrimp and other aquatic products have delicious meat and unique flavor, and are often called "river fresh" and "seafood". With the development of society and the improvement of people's consumption of aquatic products, the wild resources in rivers, lakes and seas cannot fully meet the needs. The development of aquaculture and the protection of resources have become the basic content of my country's fishery modernization. In order to achieve certain economies of scale, operators have mobilized various means to strengthen the degree of intensification, resulting in a significant increase in output. However, this also brings a series of problems that cannot be ignored, such as the increased risk of hig...
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Patent Type & Authority Patents(China)
IPC IPC(8): C07C69/734C07C67/08
CPCC07C67/08C07C69/734
Inventor 喻丽娟文华蒋明吴凡田娟陆星刘伟
Owner YANGTZE RIVER FISHERIES RES INST CHINESE ACAD OF FISHERY SCI
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