Compound traditional Chinese medicine for relieving depression, dosage form prepared from same and preparation technology of various dosage forms

Abstract

The invention provides a compound traditional Chinese medicine for relieving depression, a dosage form prepared from the same and a preparation technology of various dosage forms. The compound traditional Chinese medicine comprises radix bupleuri, scutellaria baicalensis, white peony root, radix angelica sinensis, ligusticum wallichii, radix curcumae, sun-cured ginseng, rhizoma pinelliae preparata, poria cocos, bighead atractylodes rhizome, cortex albiziae, mint, pericarpium citri reticulatae, ginger, Chinese dates and honey-fried licorice root. According to the traditional Chinese medicine formula and the dosage form prepared from the traditional Chinese medicine, cholinesterase is inhibited, the cholinomimetic function is achieved, and then the regulating effect is exerted on the digestive system and the nervous system; a cortex albiziae aqueous extract and desipramine are similar and can both obviously resist the desperation behavior of a behavioral desperation model mouse, so thatthe stay time is shortened, and the vascular depression curing effect is good; meanwhile, through long-time clinical observation of vascular depression patients, it is found that the traditional Chinese medicine has the effect of relieving clinical symptoms and does not have toxic and side effects.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine science and technology, and in particular relates to a Shuyu compound traditional Chinese medicine, its prepared dosage form and the preparation process of each dosage form. Background technique [0002] Vascular depression (VD) is a hot concept proposed in recent years. In 1997, the concept of "vascular depression" was formally proposed by Alexopoulos et al. Since then, "vascular depression" has been the common concern of many neurologists and psychiatrists. Alexopoulos et al. defined vascular depression as "depression occurring in the presence of vascular risk factors, accompanied by neuropsychological deficits and focal brain pathological changes on imaging", and speculated that vascular depression (age > 50 years old) ) is associated with vascular damage to the subfrontal cortical pathways responsible for emotion regulation and cognition. Therefore, early detection and early in...

AI Technical Summary

Problems solved by technology

[0004] Patients with vascular depression do not respond well to western medicine. Patients with deep WMHs and executive function impairment (which may damage the dorsolateral frontal pathway) are resistant to drugs and have a worse prognosis. disease to improve the frontal-subcortical pathway damage and thus improve the prognosis, while western medicine is expensive and difficult to popularize

The traditional Chinese medicine treatment of vascular depression is currently limited to methods such as tonifying vital energy or promoting blood circulation or resolving phlegm. Although certain curative effects have been obtained, there is still a lack of unified understanding of its pathogenesis, and the research on the pathogenesis is not deep enough, and the pathological aspects of traditional Chinese medicine for vascular depression cannot be revealed yet. Therefore, there are no reports of traditional Chinese medicine prescriptions for vascular depression, and there is still a lack of possible effective treatments for vascular depression.

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