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Use of nad precursors for improving maternal health and/or offspring health

A health, precursor technology, applied in metabolic diseases, medical formulations containing active ingredients, drug combinations, etc., can solve problems such as limited methods and treatments

Active Publication Date: 2019-09-13
UNIV OF IOWA RES FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, current methods and treatments for addressing these challenges are limited

Method used

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  • Use of nad precursors for improving maternal health and/or offspring health
  • Use of nad precursors for improving maternal health and/or offspring health
  • Use of nad precursors for improving maternal health and/or offspring health

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0243] Mice are a widely used model of human metabolism because of their ability to recapitulate many aspects of human health. Specifically, female mice gain significant body fat during gestation, and fasting blood glucose levels in weaned pups can be mildly to markedly hypoglycemic despite best animal management practices. Therefore, mice were used in a series of in vivo experiments to evaluate whether maternally supplemented NR has the ability to improve maternal and / or neonatal health and development. Specifically, it was investigated whether adding NR chloride (3 g / kg feed) to the diet of female mice would alter their health during and after gestation and whether this administration would have any beneficial effect on the pups.

[0244] method

[0245] Female C57BL / 6N mice were fed on Teklad 2920X diet (NC) on a 12-h light:dark cycle. Females were fed NC (n=4) or NC+NR (n=4) for 12 weeks prior to mating with a single C57BL / 6N male. Females maintained the same diet throu...

Embodiment 2

[0253] A series of in vivo murine experiments were performed to evaluate whether maternally supplemented NR has the ability to improve maternal and neonatal health and development. Note that in these and subsequent experiments and as Figure 5 As shown in , the mice were provided with NR only after their mothers had given birth. Such as Figure 6A As shown in -D, NR-supplemented mothers ate at least as much as non-supplemented mothers, but lost significant body weight, especially fat mass, while they maintained their lean body mass. These data confirm that NR supplementation increases post-pregnancy weight loss and that NR supplementation can be initiated postpartum to have this effect.

Embodiment 3

[0255] Nicotinamide riboside increases milk quantity and quality by stimulating lactation and stimulating the production of brain-derived neurotrophic factor (BDNF).

[0256] A series of in vivo murine experiments were performed to evaluate the effect of nicotinamide riboside on milk production. Such as Figure 7 As shown in , a large increase in lactation was reproduced by supplementation of post-pregnancy mothers. Such as Figure 8A As shown in -C, the concentrations of protein, carbohydrates and fat in the milk of mothers supplemented with NR were normal. Since NR-supplemented mothers produced approximately 2-fold more milk, NR-supplemented mothers passed on more calories to their offspring, contributing to maternal weight loss and neonatal development. exist Figure 9A In , the concentrations of NAD precursor vitamins in milk from control mothers and mothers supplemented with NR were determined. Milk from NR-supplemented mothers was found to have moderately higher con...

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PUM

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Abstract

Certain embodiments of the invention provide a method for improving maternal and / or offspring health, the method comprising administering an effective amount of a nicotinamide adenine dinucleotide (NAD) precursor to a female mammal (e.g., pregnant or lactating female mammal).

Description

[0001] related application [0002] This application claims priority to US Provisional Application Serial No. 62 / 427,661, filed November 29, 2016, which is incorporated herein by reference. Background technique [0003] There are many challenges associated with maintaining proper maternal health during and after pregnancy. For example, mothers often have difficulty losing unwanted weight gained during pregnancy, maintaining sufficient lactation to efficiently and time-efficiently feed their newborns, and maintaining adequate niacin status (Baker et al., J.Am. 2002 Feb;21(1):33-7). In addition, the health and brain development of newborns and young children are often limited by the availability of breast milk as well as body composition, hypoglycemia, and lack of mobility in newborns and young children. However, current methods and treatments for addressing these challenges are limited. [0004] Accordingly, there is a need for new methods and therapies for improving materna...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/15A61K31/455A61P3/02A61K31/51A61P3/04
CPCA61K45/06A61K31/661A61K31/706A61K31/7076A61P3/04A61P3/02A23L33/17A61P25/28A61P15/14A61P25/22A61K31/7084
Inventor C·M·布伦纳P·H·伊尔A·查德M·E·米古德H·史蒂文斯
Owner UNIV OF IOWA RES FOUND
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