Activator-cyclodextrin inclusion with protamine and preparation and application thereof
A technology of cyclodextrin inclusion complex and protamine, which can be used in medical preparations containing active ingredients, preparations for skin care, cosmetic preparations, etc., and can solve problems such as the decrease of total concentration
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Embodiment 1
[0094] Weigh 1g of resveratrol and 0.02g of coumarin, dissolve in 10ml of ethanol to obtain a resveratrol solution. Take 9 g of hydroxypropyl-β-cyclodextrin and dissolve it in 20 ml of purified water. The resveratrol solution was slowly added dropwise into the hydroxypropyl-β-cyclodextrin under magnetic stirring (300r / min), and the stirring was continued for 2 hours, and the solution was clear, colorless and transparent. Ethanol was distilled off under reduced pressure at 45°C, and after continuous stirring for 0.5h, freeze-drying, sublimation drying was set at -80 to -40°C, vacuum degree was 1-30Pa, time was 3-21 hours, analytical drying was set at -10-+20°C, The degree of vacuum is 1-30 Pa, the time is 1-10 hours, the water content is controlled between 0-6%, and white loose porous, spongy amorphous powder is obtained. Grind and sieve through 300 mesh to obtain a white composition for later use.
Embodiment 2
[0096] Weigh 1g of resveratrol and 0.02g of coumarin, dissolve in 10ml of ethanol to obtain a resveratrol solution. Take 11 g of hydroxypropyl-β-cyclodextrin and dissolve it in 20 ml of purified water. The resveratrol solution was slowly added dropwise into the hydroxypropyl-β-cyclodextrin under magnetic stirring (300r / min), and the stirring was continued for 2 hours, and the solution was clear, colorless and transparent. Ethanol was distilled off under reduced pressure at 45°C, and after continuous stirring for 0.5h, freeze-drying, sublimation drying was set at -80 to -40°C, vacuum degree was 1-30Pa, time was 3-21 hours, analytical drying was set at -10-+20°C, The degree of vacuum is 1-30 Pa, the time is 1-10 hours, the water content is controlled between 0-6%, and white loose porous, spongy amorphous powder is obtained. Grind and sieve through 300 mesh to obtain a white composition for later use.
Embodiment 3
[0098] Weigh 1g of resveratrol and 0.02g of coumarin, dissolve in 10ml of ethanol to obtain a resveratrol solution. Take 6.5 g of hydroxypropyl-β-cyclodextrin and dissolve it in 20 ml of purified water. The resveratrol solution was slowly added dropwise into the hydroxypropyl-β-cyclodextrin under magnetic stirring (300r / min), and the stirring was continued for 2 hours, and the solution was clear, colorless and transparent. Ethanol was distilled off under reduced pressure at 45°C, and after continuous stirring for 0.5h, freeze-drying, sublimation drying was set at -80 to -40°C, vacuum degree was 1-30Pa, time was 3-21 hours, analytical drying was set at -10-+20°C, The degree of vacuum is 1-30 Pa, the time is 1-10 hours, the water content is controlled between 0-6%, and white loose porous, spongy amorphous powder is obtained. Grind and sieve through 300 mesh to obtain a white composition for later use.
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