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Preparation process of carboxymethyl chitosan of different substitution degrees

A technology of carboxymethyl chitosan and preparation process, which is applied in the field of carboxymethyl chitosan preparation with different degrees of substitution, and can solve the different biological functions, repair, healing, moisturizing and antibacterial of carboxymethyl chitosan sex differences, can not meet the realization of the function of carboxymethyl chitosan and other issues

Inactive Publication Date: 2019-10-11
青岛童医生海洋生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, it has been found that carboxymethyl chitosan with different degrees of substitution has different biological functions, and there are significant differences in repairing, promoting healing, moisturizing, and antibacterial properties.
The control of the degree of substitution in the existing carboxymethyl chitosan production process is a preliminary control of a large range of substitution degrees, which cannot satisfy the realization of the functions of carboxymethyl chitosan with different degrees of substitution

Method used

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  • Preparation process of carboxymethyl chitosan of different substitution degrees
  • Preparation process of carboxymethyl chitosan of different substitution degrees

Examples

Experimental program
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Effect test

Embodiment 1

[0012] The chitosan powder that takes 100 grams is put into vacuum reflux reactor, adds the NaOH solution of 30% concentration of 1000 grams, after alkalization treatment 24h, material solid-liquid separation is added, the 95% concentration ethanol solution of adding 1000ml, then Add 200 grams of sodium monochloroacetate into the system, and react for 6.0 hours under vacuum-0.09MPa and 50°C insulation conditions. The product is obtained after adjusting the pH to 8.0, washing with ethanol and drying, and the detected substitution degree is 75%.

Embodiment 2

[0014] The chitosan powder that takes 100 grams is put into vacuum reflux reactor, adds the NaOH solution of 40% concentration of 1000 grams, after alkalization treatment 24h, material solid-liquid separation is added, the 95% concentration ethanol solution of adding 1000ml, then Add 250 grams of sodium monochloroacetate into the system, and react for 7.0 hours under vacuum-0.09MPa and 55°C insulation conditions. The product is obtained after adjusting the pH to 8.0, washing with ethanol and drying, and the detected substitution degree is 85%.

Embodiment 3

[0016] The chitosan powder that takes by weighing 100 grams is dropped in the vacuum reflux reactor, adds the NaOH solution of the 50% concentration of 1000 grams, after alkalization treatment 24h, material solid-liquid separation is added, the 95% concentration ethanol solution of adding 1000ml, then Add 300 grams of sodium monochloroacetate into the system, and react for 8.0 hours under vacuum-0.09MPa and 60°C insulation conditions. The product is obtained after adjusting the pH to 8.0, washing with ethanol and drying, and the detected substitution degree is 95%.

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Abstract

The invention relates to a preparation process of carboxymethyl chitosan of different substitution degrees. The preparation process includes: weighing a fixed amount of chitosan powder, adding into avacuum reflux reactor, adding a NaOH solution with the weight being 8-10 times of the weight of the chitosan and the concentration being 30-50%, performing alkalization treatment for 24 hours, performing solid-liquid separation, adding an ethanol solution with the weight being 8-10 times of the weight of the chitosan and the concentration being 95%, adding sodium monochloracetate with the weight being different times of the weight of the chitosan into the system, performing reaction under a heat preservation condition with the air pressure being smaller than 0.09MPa and the temperature being 50-60 DEG C for 6.0-8.0 hours, regulating pH to 7.5-8.5, washing with ethanol, and drying to obtain the sodium monochloracetate. The preparation process has the advantages that the carboxymethyl chitosan of different substitution degrees can be prepared, precise control of carboxymethyl chitosan substitution degree can be achieved, and different kinds of product functions can be achieved.

Description

technical field [0001] The invention relates to the field of fine chemical industry, in particular to a preparation process of carboxymethyl chitosan with different degrees of substitution. Background technique [0002] Chitin is a natural cationic polymer, which is non-toxic, harmless, safe and reliable, easy to biodegrade, and has good biocompatibility. Chitin is deacetylated by acid and alkali treatment to generate chitosan, and chitosan is only soluble in acid or acidic solution, which greatly limits its application range. Derivatizing chitosan to improve its solubility and expand its application range has become an important means to realize the application of chitosan. The study found that carboxymethyl chitosan has the best biosafety among chitosan derivatized products. After carboxymethylation modification, due to the introduction of carboxymethyl group, it becomes an amphoteric polyelectrolyte containing both amino group and carboxyl group, which destroys the orig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
CPCC08B37/003
Inventor 夏仁德杜连晖
Owner 青岛童医生海洋生物科技股份有限公司