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Pharmaceutical composition for preventing and / or treating convulsion and prepared from oriental latrine fly larvina

A technology of grain worms and compositions, which is applied in the field of anticancer drug grain worms, and can solve problems such as anti-convulsions of grain worms that do not exist

Active Publication Date: 2019-10-15
浙江佰科堂生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no relevant report that grain worms can be used for anticonvulsant

Method used

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  • Pharmaceutical composition for preventing and / or treating convulsion and prepared from oriental latrine fly larvina
  • Pharmaceutical composition for preventing and / or treating convulsion and prepared from oriental latrine fly larvina

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1: the preparation of grain worm extract

[0057] Prepare the grain worm extract according to the following method:

[0058] 1. Artificially cultured grain worms were freeze-dried, crushed and passed through a 60-mesh sieve, and then extracted with carbon dioxide fluid supercritically. The extraction parameters were pressure 25MPA, temperature 50°C, CO 2 The flow rate was 25 L / h, and the extraction was performed for 2 hours to obtain a crude product.

[0059] 2. Heat the crude product obtained in step 1 to 80°C, add 3% of the volume of the crude product in 80°C distilled water, stir for 30 minutes, and mix thoroughly; centrifuge at 5000r / min to remove the precipitate to obtain degummed grease.

[0060] 3. Take the degummed oil obtained in step 2, heat it to 60°C, add 0.3% (w / w) sodium hydroxide, stir for 1 hour, fine saponified matter appears, raise the temperature to 80°C, flocs appear and coagulate, 5000r / min centrifugal separation. Take the supernatant,...

Embodiment 2

[0062] Example 2: Anticonvulsant pharmacological test of grain worm extract

[0063] 1. Test method

[0064] Eight-week-old male BALB / c mice (body weight 18-22 g) were randomly divided into groups of 10 mice, and administered orally. The blank group was administered physiological saline 30mg / kg, and the administration components were different doses (60mg / kg, 30mg / kg, 10mg / kg) of the five-cereal worm extract group, cysteine ​​group and five-cereal worm extract group of the present invention. , cysteine ​​combination group, and the control group was administered diazepam 30mg / kg. One hour later, pentylenetetrazol (70 mg / kg) (a reagent capable of inducing convulsions) was subcutaneously injected, observed for 30 minutes, and the paroxysmal convulsions of mice maintained for at least 5 seconds or tonic convulsions of hind limbs were taken as convulsion indicators. The convulsion latency of the mice and the number of convulsive mice were recorded.

[0065] 2. Test results

[0...

Embodiment 3

[0073] Embodiment 3: the preparation of tablet

[0074] Grain worm extract 30g

[0075] Cysteine ​​1g

[0076] Get the above-mentioned active ingredient, add appropriate amount of conventional excipients for preparing tablets, mix well, and make 1000 tablets with a conventional tablet press.

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Abstract

The invention relates to a pharmaceutical composition for preventing and / or treating convulsion and prepared from oriental latrine fly larvina, in particular to the use of the oriental latrine fly larvina or extracts of the oriental latrine fly larvina used for preparing an anticonvulsant.

Description

technical field [0001] The invention relates to a new application of the anticancer drug grain worm, in particular, the use of the grain worm or its extract for preparing anticonvulsants. Background technique [0002] Convulsions (convulsion) are commonly known as convulsions, also known as convulsions. It is manifested as paroxysmal limb and facial muscle twitches, often accompanied by upturned eyeballs, staring or strabismus on both sides, and confusion. It is a common emergency in children, especially in infants and young children. The incidence of convulsions in children under the age of 6 is about 4% to 6%, which is 10 to 15 times higher than that of adults, and the younger the age, the higher the incidence. The causes of convulsions can be divided into infectious and non-infectious according to the presence or absence of infection; and can be further divided into intracranial lesions and extracranial lesions according to the parts involved. In the prior art, diazepa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61K31/198A61P25/08
CPCA61K31/198A61K35/64A61P25/08A61K2300/00
Inventor 黄玉水
Owner 浙江佰科堂生物科技股份有限公司
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