A method for screening radiation biomarkers and predicting radiation dose based on radiation-responsive biological pathways
A biomarker, radiation response technology, applied in the field of screening radiation biomarkers and predicting radiation dose based on radiation response biological pathways, can solve the problem of neglecting biological characteristics
Active Publication Date: 2021-03-16
DALIAN MARITIME UNIVERSITY
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However, the methods involved in these studies mostly ignore the unique biological characteristics. Genes do not actually exist and function in isolation, but usually function in the form of gene regulatory networks or biological pathways.
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[0034] The specific implementation manners of the present invention will be further described in detail below mainly in conjunction with the accompanying drawings.
[0035] figure 1 It is a flow chart of the present invention for screening radiation biomarkers and predicting radiation dose based on radiation-responsive biological pathways.
[0036] The present invention will be described in detail below by taking the peripheral blood gene expression profile data of mice exposed to X-rays as an example (similar data can also be easily obtained in other related experiments or databases).
[0037] The gene expression profile data includes 4 sets of data, respectively irradiating C57BL / 6 male mice with X-rays at a dose rate of 1.03Gy / min, making them receive radiation exposure doses of 0Gy, 1.1Gy, 2.2Gy and 4.4Gy 4 groups, the corresponding sample sizes are 12, 6, 6 and 6, a total of 30 samples, and the mouse peripheral blood expression profile data obtained 24 hours after irradi...
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The invention discloses a method for screening a radiation biomarker and predicting a radiation dose based on a radiation response biological pathway, and belongs to the technical field of biologicalinformation. The method comprises the steps: giving a radiation response biological pathway and retrieving gene ontology semantics, obtaining an annotated gene set in a specific species, exposing expression profile data of the same species through combined radiation, and extracting the expression profile data; obtaining differential expression features and matrixes through single factor variance analysis and protein interaction network analysis; establishing a multiple regression model by using a biostatistics method or a machine learning algorithm, and determining a significant expression feature set and an optimal statistical model type through comparative analysis of model prediction performance, namely a radiation biomarker screened based on the radiation response biological pathway and the method for predicting the radiation dose. The method provided by the invention has a very good prediction effect, and can provide a new technical method for nuclear radiation biological dose monitoring, nuclear radiation damage diagnosis and risk early warning under emergency conditions.
Description
technical field [0001] The invention belongs to the technical field of biological information, and relates to a method for screening radiation biomarkers and predicting radiation dose based on radiation response biological pathways. Background technique [0002] With the wide application of nuclear energy in military affairs or medicine, people have put forward realistic requirements for monitoring and diagnosing the amount of nuclear radiation in emergencies such as nuclear terrorist attacks or nuclear accidents. However, there are many limitations and deficiencies in the use of physical detection methods to monitor the radiation dose received by organisms / personnel and to diagnose radiation damage, such as the long time period required for monitoring, and it is difficult to fully and accurately reflect the absorbed dose of organisms / personnel and evaluate the effects of radiation damage. and risks etc. Therefore, several methods based on biomarkers have been developed to ...
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IPC IPC(8): G16B50/10G16B5/00G16B25/10
CPCG16B5/00G16B25/10G16B50/10
Inventor 赵磊汪燕李安琪陈鑫鹏宓东孙野青
Owner DALIAN MARITIME UNIVERSITY