Quaternary phosphonium salt modified montmorillonite loaded cobalt-doped zinc oxide quantum dot nano-composite antibacterial agent and preparation method thereof

A nano-composite and montmorillonite technology, applied in botany equipment and methods, biocides, disinfectants, etc., can solve the problems of poor biocompatibility, easy aggregation, easy electron-hole recombination, etc., and achieve drug resistance Strong, high antibacterial activity, good biocompatibility

Inactive Publication Date: 2019-10-22
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Relevant studies have shown that the smaller the size of nano-ZnO, the better the antibacterial performance, but the small-sized nano-ZnO itself has a large specific surface area, is easy to agglomerate, and has a wide band gap, poor biocompatibility, and easy electron-hole recombination. It is not conducive to its high-efficiency antibacterial performance

Method used

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  • Quaternary phosphonium salt modified montmorillonite loaded cobalt-doped zinc oxide quantum dot nano-composite antibacterial agent and preparation method thereof
  • Quaternary phosphonium salt modified montmorillonite loaded cobalt-doped zinc oxide quantum dot nano-composite antibacterial agent and preparation method thereof
  • Quaternary phosphonium salt modified montmorillonite loaded cobalt-doped zinc oxide quantum dot nano-composite antibacterial agent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Step 1: Weigh 5g of sodium montmorillonite and disperse it in 100mL of deionized water, heat and stir in a water bath at 80°C for 30min; disperse 2.5g of hexadecyltributylphosphonium bromide in 50mL of deionized water, and wait until it is completely dissolved , added to the sodium-based montmorillonite dispersion, stirred for 2 hours under the condition of heating in a water bath at 60°C, and then left to stand for 1 hour to cool down, then repeatedly filtered and washed with a vacuum filter until no Br ions were detected (use AgNO 3 test). After drying at 60°C for 24 hours, grind it into a fine powder to obtain quaternary phosphonium salt modified montmorillonite;

[0027] Step 2: Weigh 5mmol of zinc acetate dihydrate and 0.035mmol of cobalt acetate tetrahydrate and disperse them in 100mL of absolute ethanol. After stirring evenly, add 30mg of quaternary phosphonium salt modified MMT, pour into a three-necked flask, and heat in a water bath at 80°C React for 1 hour ...

Embodiment 2

[0030] Step 1: Weigh 8g of sodium montmorillonite and disperse it in 150mL of deionized water, heat and stir in a water bath at 80°C for 30min; disperse 4g of hexadecyltributylphosphonium bromide in 75mL of deionized water, and wait until it is completely dissolved, Add it to the sodium-based montmorillonite dispersion, stir for 2 hours under the condition of heating in a water bath at 70°C, then let it stand for 1 hour to cool down, and then use a vacuum filter to filter and wash it repeatedly until no Br ions are detected (use AgNO 3 test). After drying at 60°C for 24 hours, grind it into a fine powder to obtain quaternary phosphonium salt modified montmorillonite;

[0031] Step 2: Weigh 5mmol of zinc acetate dihydrate and 0.035mmol of cobalt acetate tetrahydrate and disperse them in 100mL of absolute ethanol. After stirring evenly, add 40mg of quaternary phosphonium salt modified MMT, pour into a three-necked flask, and heat in a water bath at 70°C React for 1.5 hours to o...

Embodiment 3

[0033]Step 1: Weigh 5g of sodium montmorillonite and disperse it in 100mL of deionized water, heat and stir in a water bath at 80°C for 30min; disperse 2.5g of hexadecyltributylphosphonium bromide in 50mL of deionized water, and wait until it is completely dissolved , added to the sodium-based montmorillonite dispersion, stirred for 2 hours under the condition of heating in a water bath at 80° C., left to stand for 2 hours to cool down, and then repeatedly suction-filtered and washed with a vacuum filtration device until no Br ions were detected (using AgNO 3 test). After drying at 60°C for 24 hours, grind it into a fine powder to obtain quaternary phosphonium salt modified montmorillonite;

[0034] Step 2: Weigh 5mmol of zinc acetate dihydrate and 0.035mmol of cobalt acetate tetrahydrate and disperse them in 100mL of absolute ethanol. After stirring evenly, add 60mg of quaternary phosphonium salt modified MMT, pour into a three-necked flask, and heat in a water bath at 60°C ...

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Abstract

The invention discloses a quaternary phosphonium salt modified montmorillonite (MMT) loaded cobalt-doped zinc oxide quantum dot nano-composite antibacterial agent and a preparation method thereof. Thehuge specific surface area and high absorption rate of quaternary phosphonium salt modified MMT are utilized to adsorb bacteria to the surface, and then the quaternary phosphonium salt modified MMT cooperates with the cobalt (CO) doped zinc oxide quantum dots (ZnO QDs) loaded on the surface and between the layers of montmorillonite to play an efficient antibacterial role so as to kill bacteria, and finally the novel nano-composite antibacterial agent with good biocompatibility and high antibacterial activity can be prepared. The quaternary phosphonium salt modified montmorillonite loaded cobalt-doped zinc oxide quantum dot nano-composite antibacterial agent prepared according to the invention has the advantages of safety, environmental protection, strong drug resistance, etc., and the minimum inhibitory concentration to escherichia coli can reach 1.8mg/mL.

Description

technical field [0001] The invention relates to a high-efficiency antibacterial agent, in particular to a quaternary phosphonium salt-modified montmorillonite-loaded cobalt-doped zinc oxide quantum dot nanocomposite antibacterial agent and a preparation method thereof. Background technique [0002] In recent years, due to insufficient anticipation and poor prevention of the negative impact of highly developed industries, people have led to three global crises: resource shortage, environmental pollution, and ecological destruction. At the same time, the improper use of antimicrobials has led to the emergence of various pathogenic bacteria, fungi and viruses, as well as the increase of drug-resistant bacteria and the emergence of super-resistant bacteria. The research and development of various antibacterial agents has become a current research hotspot, among which inorganic antibacterial materials have received more and more attention because of their low price, high safety p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/16A01N57/34A01N25/08A01P1/00
CPCA01N59/16A01N57/34A01N25/08
Inventor 刘俊莉王宇涵刘辉李军奇何选盟薛祯祯
Owner SHAANXI UNIV OF SCI & TECH
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