Apparatus and methods for continuous diagnostics of macromolecules

A macromolecular, molar technology, applied in the field of equipment and methods for continuous diagnosis of macromolecules, capable of solving problems of reliability, high error rate, poor signal-to-noise ratio, etc.

Active Publication Date: 2019-10-22
AXBIO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Variations in the mass of the device in a module can lead to poor signal-to-noise ratios, while differences in osmolality of solutions on either side of a membrane containing nanopores can cause reliability issues
Furthermore, the methods used to control the rate of movement of macromolecules across nanopores can be less than ideal, leading to high error rates

Method used

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  • Apparatus and methods for continuous diagnostics of macromolecules
  • Apparatus and methods for continuous diagnostics of macromolecules
  • Apparatus and methods for continuous diagnostics of macromolecules

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Embodiment Construction

[0019] For the purposes of the following description, it is to be understood that, unless expressly indicated to the contrary, the embodiments provided by the invention may assume various alternative modifications and step sequences. Furthermore, except in the examples or where otherwise indicated, all numbers used in the specification and claims, eg, expressing amounts of ingredients, are to be understood as being modified in all instances by the term "about". Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and claims are approximations that can vary depending upon the desired properties sought to be obtained. At the very least, and not as an attempt to limit the application of the doctrine of equivalents to the scope of the claims, each numerical parameter should at least be construed in light of the number of reported significant digits and by applying normal rounding techniques.

[0020] Notwithstanding that ...

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Abstract

Devices, apparatus and methods for nanopore sequencing macromolecules are disclosed. The devices and apparatus include independently controllable fluid channels (101, 104) bi-directionally coupled toa measurement module (100). By flowing a lipid-containing solution through the channels (101, 104), a lipidic bilayer nanopore (111) can be assembled in the measurement module (100).

Description

[0001] This application claims the benefit of U.S. Provisional Application No. 62 / 458,840, filed February 14, 2017, which is hereby incorporated by reference in its entirety, under Title 35, United States Code, Section 119(e). technical field [0002] The present invention relates to devices, devices and methods for sequencing macromolecules. The apparatus and apparatus include independently controllable fluid channels bi-directionally coupled to a measurement module. Background technique [0003] Solid-state nanopores and biological nanopores are increasingly becoming the focus of developing low-cost high-throughput macromolecular sequencing systems. The approach to nanopore-based sensing employs the measurement of ion current flow through nanopores incorporated within a high resistance amphiphilic membrane between electrodes provided on either side of the membrane. The flow of ion currents through the nanopore is regulated by the different nucleotide bases of the DNA stra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/487
CPCC12Q1/6869G01N33/48721G01N27/44791B01L3/502715B01L3/502738B01L3/502707B01L2400/0622B01L2300/0645B01L2300/0861B01L2300/0896C12Q2535/122C12Q2565/629C12Q2565/631
Inventor 伊戈尔·伊万诺夫牛立程艾伯特·楚恩田辉邓素华
Owner AXBIO INC
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