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Intestinal flora reconstruction method

A technology of intestinal flora and probiotics, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, unknown raw materials, etc., can solve the problems of lack of intestinal flora, improve glucose metabolism, enhance intestinal mucosal barrier, The effect of promoting the reconstruction of intestinal flora

Pending Publication Date: 2019-10-25
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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Problems solved by technology

[0004] But at present, there is still a lack of research on T2DM-related improvement of intestinal flora

Method used

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Embodiment 1

[0033] 1. Processing method

[0034] After the T2DM model was successfully established, in order to maintain the hyperglycemia state, HFD feeding was continued, and 10 mice were kept as the diabetic control group (DM) without any treatment, and the rest were given antibiotic pretreatment (gentamycin sulfate) for 1 week. Injection 80mg: 80,000 units / each), dissolved in drinking water at a concentration of 1g / L, and then randomly divided into 2 groups according to fasting blood sugar and body weight, with at least 10 rats in each group: antibiotic pretreatment + probiotic placebo ( DM+AB), and the antibiotic pretreatment+probiotics experimental group (DM+AB+PRO), were intragastrically administered once a day for 4 weeks in total. The probiotic solvent is in 1×PBS (pH7.4), and the dosage is 10 9 CFU / mouse, each mouse was gavaged with 0.2ml, the DM+AB group was gavaged with the same amount of probiotic placebo, and the DM group was gavaged with the same amount of PBS.

[0035] 2...

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Abstract

The invention relates to an intestinal flora reconstruction method. By the aid of antibiotic pretreatment and probiotic intervention, intestinal flora reconstruction is promoted, intestinal permeability is reduced to enhance intestinal mucosal barriers, and bile acid components are changed to play a certain role in improvement of glucose metabolism.

Description

technical field [0001] The invention belongs to the field of type 2 diabetes, and particularly relates to a method for rebuilding intestinal flora. Background technique [0002] With changes in lifestyle and population aging, the prevalence of type 2 diabetes mellitus (T2DM) is gradually increasing worldwide. According to data from the International Diabetes Federation survey, an estimated 425 million people (20-79 years old) were living with diabetes in 2017, a quarter of them were aged 65 or older, and in high- and middle-income countries, The incidence of diabetes peaks in the 75-79 age group and 60-74 age group respectively. It is estimated that by 2045, the total number of diabetic patients will exceed 629 million, of which T2DM accounts for 90% of diabetes. Therefore, T2DM is the main burden of diseases in the elderly, and it is very important to find and reduce the risk of diabetes to control T2DM. [0003] Among the many risk factors leading to obesity and T2DM, th...

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Application Information

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IPC IPC(8): A61K35/741A61K31/7036A61P1/00A61K35/747A61K35/745
CPCA61K31/7036A61K35/741A61P1/00A61K35/747A61K35/745A61K2300/00
Inventor 顾燕云张翼飞李雪琳王卫庆宁光
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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