EP4 receptor antagonist and PD-1 inhibitor combined and used for treating cancer

A receptor antagonist, PD-1 technology, applied in the field of biomedicine, can solve the problems of low objective response rate and high death toll
CN110386941AInactive Publication Date: 2019-10-29SHANGHAI YUYAO BIOTECH LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI YUYAO BIOTECH LTD
Publication Date
2019-10-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides an EP4 receptor antagonist and a PD-1 inhibitor combined and used for treating cancer. The invention provides the product combination, including a first medicine composition (i)and a second medicine composition (ii), the first medicine composition contains a first active ingredient (a) which is the EP4 receptor antagonist and an acceptable vector on pharmacy, the second medicine composition contains a second active ingredient (b) which is the PD-1 inhibitor, and an acceptable vector on the pharmacy; and the medicine compositions of the first medicine composition and thesecond medicine composition are different, or the same. According to the product combination, malignant tumor can be treated synergistically.
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Description

technical field

[0001] The present invention relates to the field of biomedicine, in particular to the combination of EP4 receptor antagonist and PD-1 inhibitor for the treatment of cancer. Background technique

[0002] Cancer has become one of the most terrifying killers threatening human life and health. According to the 2018 "Global Cancer Report" released by the International Agency for Research on Cancer (IARC), there will be 18.1 million new cancer cases worldwide in 2018, and about 9.6 million people will die of cancer. cancer, and its morbidity and mortality are increasing year by year. According to the report, my country ranks first in the world in terms of cancer incidence and mortality. Among them, the number of new cases in my country accounted for 3.804 million cases and the number of deaths accounted for 2.296 million cases.

[0003] Following surgical treatment, radiotherapy and chemotherapy drug treatment, the development of tumor immunotherapy represented b...

Claims

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