Asthma biomarker and application thereof

A biomarker and asthma technology, applied in the field of biomedicine, can solve the problems that asthma diagnosis methods cannot achieve early warning, cannot predict the onset and development trend of asthma, and achieve the goal of improving efficiency, ensuring accuracy, and improving comparison efficiency effect

Pending Publication Date: 2019-11-01
SHENZHEN HUADA GENE INST
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Therefore, the object of the present invention is to provide biomarkers for assessing the risk of asthma or early diagnosis of asthma, as well as methods for diagnosing and asse

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Asthma biomarker and application thereof
  • Asthma biomarker and application thereof
  • Asthma biomarker and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] 1.1 Sample collection

[0096] Referring to the method described in A metagenome-wide association study of gut microbiota in type2diabetes (Qin, J. et al. Nature 490, 55-60 (2012)), the feces samples were collected and transported frozen and quickly transferred to -80°C for storage. Perform DNA extraction to obtain an extracted DNA sample. Stool samples from asthmatic and non-asthmatic subjects were obtained from adult twins in the UK, totaling 250 cases, and then 29 samples with missing phenotypes were discarded from the 250 total samples. The means can not determine the samples of disease or not, the remaining 221 samples include 185 healthy samples and 36 asthmatic samples.

[0097] 1.2 Metagenome sequencing and assembly

[0098] The extracted DNA samples were used to construct a sequencing library, and two-way (Paired-end) metagenomic sequencing (insert fragment 350bp, read length 100bp) was performed on the Illumina HiSeq2000 sequencing platform. Filter the data...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the field of biomedicine and particularly relates to an asthma biomarker and application thereof. The biomarker for asthma or related diseases comprises at least one of Bacterodies stercoris and/or analogue thereof, Eggerthella lenta and/or analogue thereof and Sutterella wadsworthensis and/or analogue thereof. The biomarker for early diagnosis of asthma or related diseases and a method for diagnosing asthma or related diseases and predicting the risk of illness can overcome the defect that an existing asthma diagnosing method cannot achieve early warning or predict pathogenesis of asthma and the like.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an asthma biomarker and its application. Specifically, the present invention relates to a biomarker for asthma or related diseases, a method for diagnosing or predicting the risk of asthma or related diseases, a kit, and the use of the asthma biomarker in the preparation of the kit. Background technique [0002] Asthma (English: asthma, also known as asthma) is a common chronic inflammatory disease of the airways, the main features are variable and recurrent symptoms, reversible airflow obstruction and bronchospasm. Common symptoms are wheezing, coughing, chest tightness, chest tightness, and difficulty breathing. Coughing may or may not produce phlegm in the lungs, but it is usually difficult to cough up. During an asthma attack, a pus-like substance may develop due to an increase in the number of white blood cells called eosinophils. Symptoms are usually worse in the evening and e...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C12Q1/6883C12Q1/689
CPCC12Q1/6883C12Q1/689C12Q2600/136
Inventor 郭锐进王奇贾慧珏鞠艳梅朱杰赵慧
Owner SHENZHEN HUADA GENE INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap