Mouthwash and preparation method thereof

A technology of mouthwash and biguanides, which is applied in the field of mouthwash and its preparation, can solve the problems of lysozyme with single antibacterial effect and unsatisfactory antibacterial effect, achieve good anti-caries effect, good treatment of oral ulcers, and good stability Effect

Inactive Publication Date: 2019-11-12
武汉品瑞医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used antibacterial ingredient on the market is lysozyme, but the antibacterial effect of lysozyme is single, especially the antibacterial effect on most Gram-negative bacteria is not ideal

Method used

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  • Mouthwash and preparation method thereof
  • Mouthwash and preparation method thereof
  • Mouthwash and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A mouthwash comprising the following components: lysozyme, biguanide compound and water, wherein the mass ratio of lysozyme, biguanide compound and water is 0.1:3:100; wherein the biguanide compound includes chlorhexidine gluconate and the mixture of polyhexamethylene biguanide hydrochloride, the mass ratio of chlorhexidine gluconate and polyhexamethylene biguanide hydrochloride is 5:8;

[0026] The preparation method of the above-mentioned mouthwash is as follows: according to the above-mentioned mass ratio, dissolve lysozyme and biguanide compounds in water at a temperature of 40° C. and stir for 3 hours to obtain the mouthwash.

Embodiment 2

[0028] A mouthwash comprising the following components: lysozyme, biguanide compounds and water, wherein the mass ratio of lysozyme, biguanide compounds and water is 0.1:4:105; wherein the biguanide compounds include chlorhexidine acetate and The mixture of polyhexamethylene biguanide hydrochloride, the mass ratio of chlorhexidine acetate and polyhexamethylene biguanide hydrochloride is 5:8;

[0029] The preparation method of the above-mentioned mouthwash is as follows: according to the above-mentioned mass ratio, dissolve lysozyme and biguanide compounds in water at a temperature of 40° C. and stir for 3 hours to obtain the mouthwash.

Embodiment 3

[0031] A mouthwash comprising the following components: lysozyme, biguanide compounds and water, wherein the mass ratio of lysozyme, biguanide compounds and water is 0.1:5:110; wherein the biguanide compounds include chlorhexidine acetate, The mixture of chlorhexidine gluconate and polyhexamethylene biguanide hydrochloride, the mass ratio of chlorhexidine gluconate and polyhexamethylene biguanide hydrochloride is 1:5:8;

[0032] The preparation method of the above-mentioned mouthwash is as follows: according to the above-mentioned mass ratio, dissolve lysozyme and biguanide compounds in water at a temperature of 40° C. and stir for 3 hours to obtain the mouthwash.

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Abstract

The invention provides a mouthwash. The mouthwash adopts biguanide compounds such as polyhexamethylene biguanide hydrochloride as a raw material, has good efficacy on Gram-negative bacteria which aredifficult to treat by common fungicides, and has good bacteriostatic effect on the Gram-negative bacteria. Experiments show that the mouthwash has good bacteriostatic effect on escherichia coli and helicobacter pylori. The mouthwash synergistically uses lysozyme, polyhexamethylene biguanide and chlorhexidine gluconate, and has wider sterilization range. Experiments show that the mouthwash not onlyhas a good bacteriostatic effect on Gram-negative bacteria, but also has a good bacteriostatic effect on staphylococcus aureus and candida albicans. The mouthwash has the advantages of good stability, good safety and no irritation to skin mucosa. The mouthwash also comprises plant extracts, wherein the plant extracts are prepared from the raw materials of winkled gianthyssop herb, fortune eupatorium herb, pseudo-ginseng, plectranthus tomentosa and sarcandra glabra, and after extraction, the plant extracts have good effects of treating oral ulcer and preventing caries.

Description

technical field [0001] The invention relates to the technical field of oral cavity cleaning and antibacterial, in particular to a mouthwash and a preparation method thereof. Background technique [0002] The human oral cavity is an environment prone to mixed infections, because the humidity, temperature, and nutrients in the oral cavity provide favorable conditions for the growth of various bacteria. The microorganisms that colonize the oral cavity include complex types of bacteria, fungi, mycoplasma, chlamydia, protozoa and viruses. These microorganisms live in different parts of the oral cavity, compete and antagonize, forming an oral micro-ecosystem, which is closely related to the health and disease of the host oral cavity . The factors of oral microecological dysbiosis are complex, which can be caused by age, diet, hygiene, health status and the use of antibiotics, etc., and may also be affected by the interaction between microorganisms. Oral diseases lead to oral mic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/66A61K8/84A61K8/43A61K36/532A61Q11/00A61P1/02A61P31/02A61P31/04A61P31/10
CPCA61K8/9789A61K8/84A61K8/43A61K8/66A61K36/532A61K36/28A61K36/258A61K36/53A61K36/185A61Q11/00A61P1/02A61P31/04A61P31/02A61P31/10A61K2800/805A61K2300/00Y02A50/30
Inventor 鲁建华
Owner 武汉品瑞医学科技有限公司
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