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Preparation methods of medicine combination and HPLC fingerprint establishment method thereof

A technique for fingerprinting and establishing methods, which is applied in the establishment of HPLC fingerprints and the preparation of pharmaceutical compositions, and can solve problems such as inability to ensure that effective substances are fully extracted and utilized

Active Publication Date: 2019-11-15
劲牌持正堂药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the embodiment of the present application is to provide a preparation method of a pharmaceutical composition and a method for establishing its HPLC fingerprint, which aims to improve the problem that the current pharmaceutical composition cannot ensure that the effective substances of each medicinal material are fully extracted and utilized

Method used

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  • Preparation methods of medicine combination and HPLC fingerprint establishment method thereof
  • Preparation methods of medicine combination and HPLC fingerprint establishment method thereof
  • Preparation methods of medicine combination and HPLC fingerprint establishment method thereof

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preparation example Construction

[0053] The embodiment of the application provides a method for preparing a pharmaceutical composition, including:

[0054] According to parts by weight, mix 15-25 parts of astragalus, 8-12 parts of ginseng, 3-8 parts of licorice, 1-3 parts of cinnamon, and 1-3 parts of ginger. After extracting 2-4 times, combine the extracts, Concentrated at 60-80℃ to a relative density of 1.05~1.20g / cm 3 Of concrete.

[0055] After mixing astragalus, ginseng, licorice, cinnamon and ginger, extract 2-4 times, combine the extracts and concentrate at 60-80℃ to a relative density of 1.05~1.20g / cm 3 Of concrete. It can be ensured that the final obtained medicinal composition extract contains the effective substances of each raw material of astragalus, ginseng, licorice, cinnamon and ginger, and the full utilization of each effective substance is ensured. The pharmaceutical composition prepared by the method can be used to improve weak vitality, mental fatigue, muscle tenderness, low diet and the like....

Embodiment 1

[0108] This embodiment provides a pharmaceutical composition, which is prepared as follows:

[0109] Weigh 2kg of prescription medicinal materials Astragalus, 1kg of ginseng, 0.5kg of licorice, 0.2kg of cinnamon, and 0.2kg of ginger, add water and extract twice, add 8 times the amount of water for the first time, soak for 30 minutes, then heat and boil, keep slightly boiling for extraction For 1.5 hours, add 6 times the amount of water for the second time, heat and keep slightly boiling for 1 hour, combine the two extracts and filter with 120 mesh. The filtrate was dried under reduced pressure at a temperature of 70°C and a vacuum degree of -0.06~0.08MPa to an extract with a relative density of 1.10 (70°C). Under the conditions of induced draft fan frequency 40Hz~50Hz, atomizer frequency 40Hz~50Hz and inlet air temperature 150-170℃, the dry paste powder is 1.26kg, and the moisture content of the dry paste powder is ≤4.5%. The dry paste powder was added to 10% maltodextrin for we...

Embodiment 2

[0111] This embodiment provides a pharmaceutical composition, which is prepared as follows:

[0112] Weigh 2kg of prescription medicinal materials Astragalus, 1kg of ginseng, 0.5kg of licorice, 0.2kg of ginger, add water to extract three times, add 8 times the amount of water for the first time, soak for 30 minutes, then heat and boil, keep slightly boiling for 1.5 hours, second Add 6 times the amount of water each time, heat and maintain the slightly boiling extraction for 1 hour, add 6 times the amount of water for the third time, heat and maintain the slightly boiling extraction for 1 hour, combine the three extracts and filter with 120 mesh. The filtrate is dried under reduced pressure at a temperature of 70°C and a vacuum degree of -0.06~0.08MPa to an extract with a relative density of 1.25 (70°C). The dry paste was dried under reduced pressure at 70°C to obtain a dry paste powder of 1.42kg, and the water content of the dry paste powder was ≤4.5%. Take another 1kg of cinnam...

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Abstract

The application relates to the field of traditional Chinese medicine, and particularly to preparation methods of a medicine combination and an HPLC fingerprint establishment method of thereof. 15-25 parts of astragalus, 8-12 parts of ginseng, 3-8 parts of glycyrrhiza, 1-3 parts of cinnamon and 1-3 parts of ginger are mixed, then extraction is carried out 2-4 times, and then extracts are combined,and are concentrated into an extract with relative density of 1.05-1.20g / cm<3> of at 60-80 DEG C. The methods can ensure that the finally obtained medicine combination extract contains valid substances of all raw materials of the scutellaria, the ginseng, the glycyrrhiza, the cinnamon and the ginger, ensure full utilization of all the valid substances, and thus improve quality of the medicine combination. The HPLC fingerprint establishment method can be used to judge the valid substances in the prepared medicine combination, and thus identify the quality of the medicine combination.

Description

Technical field [0001] This application relates to the field of traditional Chinese medicine, and specifically to a method for preparing a pharmaceutical composition and a method for establishing an HPLC fingerprint. Background technique [0002] Classic famous prescriptions have a long and rich history of human use in our country, and they are a valuable asset left by our ancestors. In order to develop the cause of Chinese medicine, the state has simplified the application for listing of traditional Chinese medicine compound preparations derived from ancient classic prescriptions in the national published catalog. At the same time, the intellectual property rights of traditional Chinese medicine preparations are protected by the state, and a series of regulations and technical requirements have been promulgated to stipulate and require the selection, declaration, simplified registration and approval of classic prescriptions. [0003] Baoyuan Decoction is from Sun Zhihong's "Concis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/06G01N30/14G01N30/86
CPCG01N30/06G01N30/14G01N30/8686
Inventor 成焕波翟红伟胡辉刘源才许梦玲靳步昆涂名扬
Owner 劲牌持正堂药业有限公司
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