Phnom Penh rose active extract, skin care compound, preparation and application of extract and skin care product

A Phnom Penh rose, extract technology, applied in the field of skin care products, can solve the problems of safety and allergies

Active Publication Date: 2019-11-22
云南西草资源开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the antioxidants added in some skin care products are not of

Method used

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  • Phnom Penh rose active extract, skin care compound, preparation and application of extract and skin care product
  • Phnom Penh rose active extract, skin care compound, preparation and application of extract and skin care product
  • Phnom Penh rose active extract, skin care compound, preparation and application of extract and skin care product

Examples

Experimental program
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Effect test

preparation example Construction

[0047] In addition, the above-mentioned preparation method of the active extract of Rose Phnom Penh comprises the following steps: after crushing the dried rose flower of Phnom Penh Rose, cold leaching with ethanol aqueous solution with a volume fraction of 65%-95% for several times, combining the filtrates to obtain the extract, The extract was concentrated under reduced pressure to obtain ethanol extract. Add water to the ethanol extract to suspend, extract with petroleum ether for several times, and concentrate under reduced pressure to obtain petroleum ether extract and ethanol extract. The ethanol extract is dissolved in water, and the active ingredient is enriched by macroporous adsorption resin (HP-20). First, the volume fraction is 0-30% methanol aqueous solution to elute for 4-10 column volumes to remove the large polar component, and then use volume fraction The methanol aqueous solution with a fraction of 50%-70% is eluted in 8-10 column volumes, and the eluate obta...

Embodiment 1

[0059] The present embodiment mainly extracts a kind of Phnom Penh Rose extract from Phnom Penh Rose, specifically comprises the following steps:

[0060] After 800g of Phnom Penh rose dried flower is pulverized, it is 95% ethanol aqueous solution cold leaching extraction three times with volume fraction, and the filtrate after merging is concentrated under reduced pressure and obtains 95% ethanol extract; Remaining plant residue is 65% ethanol aqueous solution cooling After leaching three times, the combined filtrate was concentrated under reduced pressure to obtain a 65% ethanol extract. Add water to the 95% ethanol extract to suspend, extract three times with petroleum ether, and concentrate under reduced pressure to obtain petroleum ether extract (7.431 g) and the aqueous phase part of the 95% ethanol extract. The aqueous phase part of the 95% ethanol extract and the 65% ethanol extract were combined, and freeze-dried to obtain the ethanol aqueous crude extract of Rose Phn...

Embodiment 2

[0064] This embodiment mainly isolates the skin care compound from the active extract of Rose Phnom Penh prepared in Example 1, and the specific steps are as follows:

[0065] Select 15 g of the active extract of Rose Phnom Penh prepared in Example 1 through silica gel (200 mesh) normal phase silica gel column chromatography, with chloroform-methanol solvent system (chloroform / methanol volume ratio is 9:1, 7:1, 5:1, 3:1, 1:1), and the eluate was combined into 9 fractions (D1-D9) after detection by thin-layer chromatography. Fraction D2 (eluted when the volume ratio of chloroform / methanol was 9:1) was separated by semi-preparative HPLC (YMC-Pack ODS-AQ, 40% methanol-water) to obtain compound 1 (44mg); Fraction D3 (chloroform eluting at a volume ratio of 5:1) to compound 2 (30 mg) was separated by semi-preparative HPLC (YMC-Pack ODS-AQ, 45% methanol-water).

[0066] Compounds 1 and 2 obtained in the above-mentioned separation steps of the present embodiment were subjected to 1...

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Abstract

The invention relates to a Phnom Penh rose active extract, a skin care compound, preparation and application of the extract and a skin care product. According to the mainly-adopted technical scheme, the Phnom Penh rose active extract comprises gallic acid ethyl ester and phenethyl 6'-O-galloyl-belta-D-glucoside. In the Phnom Penh rose active extract, the mass percentage content of the gallic acidethyl ester is higher than or equal to 0.325%, and the mass percentage content of the phenethyl 6'-O-galloyl-belta-D-glucoside is higher than or equal to 0.25%. The skin care compound is gallic acid ethyl ester or phenethyl 6'-O-galloyl-belta-D-glucoside. The main aim is to provide or prepare the Phnom Penh rose active extract and separate the skin care product from the Phnom Penh rose active extract. The Phnom Penh rose active extract and the skin care compound can be used as a DPPH free radical scavenger and a tyrosinase inhibitor and applied to preparation of the anti-aging and whitening skin care product.

Description

technical field [0001] The invention relates to the technical field of skin care products, in particular to an active extract of Phnom Penh Rose, a skin care compound, its preparation and application, and a skin care product. Background technique [0002] With the improvement of people's living standards, how to resist skin aging and whiten skin has become a deeper need after people's basic skin care is satisfied. [0003] Skin aging is divided into endogenous aging and exogenous aging, among which endogenous aging is also called natural aging, which is due to the changes of hormones with age. Exogenous aging is mainly due to excessive ultraviolet radiation, resulting in excessive free radicals or reactive oxygen species (ROS) in the body, which cause oxidative damage to the body. In addition, ROS will also activate matrix metalloproteinases (MMPs), which will lead to the degradation of collagen and elastin, resulting in skin aging symptoms such as skin relaxation, wrinkles...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61Q19/00A61Q19/02A61Q19/08
CPCA61K8/9789A61Q19/00A61Q19/02A61Q19/08A61K2800/782A61K2800/805A61K2800/84
Inventor 杜芝芝李明祥解静张红霞
Owner 云南西草资源开发有限公司
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