Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Organic-inorganic hybrid dressing for wound repair and preparation method and application thereof

A wound repair and organic technology, which is applied to the field of organic-inorganic hybrid dressings for wound repair and its preparation, can solve the problems of easy generation of drug resistance, slow wound healing, and frequent dressing changes, and achieves non-immunogenicity, promoting Healing, large surface area effect

Inactive Publication Date: 2019-11-29
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, traditional Chinese medicine chemical ointments and antibiotics are commonly used to treat wounds in China, but there are disadvantages such as frequent dressing changes, slow wound healing, and easy drug resistance.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Organic-inorganic hybrid dressing for wound repair and preparation method and application thereof
  • Organic-inorganic hybrid dressing for wound repair and preparation method and application thereof
  • Organic-inorganic hybrid dressing for wound repair and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, preparation of fucoidan sulfate organic-inorganic hybrid dressing (FGS1)

[0023] Weigh 1 g of fucoidan sulfate, dissolve it in 100 mL of distilled water, and stir evenly to prepare a 1% fucoidan sulfate solution. 3-Glycidyloxypropyltrimethoxysilane was added dropwise to the polysaccharide solution to make the final concentration 1%, and reacted at 25° C. for 24 hours. After the reaction, tetramethoxysilane (TMOS) was added to the solution to make the final concentration 1%. 30°C, react for 24h. After the reaction is completed, the ethanol with a final concentration of 65% is used for precipitation, and the precipitate is dried at 50° C. to prepare an organic-inorganic hybrid dressing.

Embodiment 2

[0024] Embodiment 2, the preparation of fucoidan sulfate organic-inorganic hybrid dressing (FGS2)

[0025] Weigh 3 g of fucoidan sulfate, dissolve it in 100 mL of distilled water, and stir evenly to prepare a 3% fucoidan sulfate solution. Add 3-glycidyloxypropyltrimethoxysilane dropwise to the polysaccharide solution to make the final concentration 3%, and react at 15°C for 24h. After the reaction, tetramethoxysilane (TMOS) was added to the solution to make the final concentration 2%. 25°C, react for 48h. After the reaction is completed, the ethanol with a final concentration of 70% is used for precipitation, and the precipitate is dried at 60° C. to prepare an organic-inorganic hybrid dressing.

Embodiment 3

[0026] Embodiment 3, the preparation of fucoidan sulfate organic-inorganic hybrid dressing (FGS3)

[0027] Weigh 2 g of fucoidan sulfate, dissolve it in 100 mL of distilled water, and stir evenly to prepare a 2% fucoidan sulfate solution. 3-glycidyloxypropyltrimethoxysilane was added dropwise to the polysaccharide solution to make the final concentration 2%, and reacted at 25° C. for 17 hours. After the reaction, tetramethoxysilane (TMOS) was added to the solution to make the final concentration 2%. 25°C, react for 24h. After the reaction is completed, the ethanol with a final concentration of 72% is used for precipitation, and the precipitate is dried at 50° C. to prepare an organic-inorganic hybrid dressing.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an organic-inorganic hybrid dressing for wound repair, particularly chronic wound repair, and a preparation method and application thereof, and more particularly relates to an organic-inorganic hybrid nano dressing prepared by modifying silica with natural sulphate polysaccharide under an action of a silane coupling agent through a sol-gel technology. The preparation methodof the dressing is simple and easy to implement. The prepared biological dressing has good biocompatibility and no cytotoxicity, can adsorb inflammatory factors, promote cell migration and angiogenesis, and promote chronic wound healing. The organic-inorganic hybrid dressing is particularly suitable for treatment and nursing of chronic refractory wounds, especially diabetic ulcers, widely existingin clinical practice.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an organic-inorganic hybrid dressing for wound repair (especially chronic wound repair) and its preparation method and application. Background technique [0002] Diabetes is a common disease caused by the interaction of genetic and environmental factors. Clinically, hyperglycemia is the main sign, and common symptoms include polydipsia, polyuria, polyphagia, and weight loss. In 2018, the International Diabetes Federation released the eighth edition of the global diabetes map. The results show that the number of adults with diabetes worldwide (aged 20-79) has nearly tripled from 151 million in 2000 to 425 million in 2017. It is estimated that by 2045, the number of people with diabetes may reach 629 million. There are currently 425 million diabetic patients in the world. Among all countries, China has the heaviest burden of diabetes, and the number of patients (114 mil...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0023A61L26/0066A61L26/0085A61L2300/232A61L2300/412C08L5/00
Inventor 王晶张全斌耿丽华岳洋张虹吴宁
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com