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A kind of thieno[3,2-d]pyrimidine derivatives and its application

A 2-d, derivative technology, applied in the field of medicine, can solve problems such as adverse reactions of patients and affecting the quality of life of patients

Active Publication Date: 2022-01-07
SHAANXI SCI TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, there are also a large number of literature reports that fragments containing thieno[3,2-d]pyrimidine have good antitumor activity; however, when taking this kind of drugs, patients often have adverse reactions, which affect the quality of life of patients

Method used

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  • A kind of thieno[3,2-d]pyrimidine derivatives and its application
  • A kind of thieno[3,2-d]pyrimidine derivatives and its application
  • A kind of thieno[3,2-d]pyrimidine derivatives and its application

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Embodiment Construction

[0039] The Examples and Preparations provided hereinafter further illustrate and illustrate the compounds of the present invention and methods for their preparation. It should be understood that the scope of the following examples and preparations does not limit the scope of the invention in any way.

[0040] The following synthetic schemes describe the preparation of the derivatives of formula (I) of the present invention, all starting materials are prepared by the methods described in the following synthetic schemes, by methods well known to those of ordinary skill in the field of organic chemistry or are commercially available. All final derivatives of the present invention are prepared by the methods described in the following synthetic schemes or by methods analogous thereto, which are well known to those skilled in the art of organic chemistry. The substituents n and Ar of all compounds in the scheme are as defined in the claims. The synthetic route is as follows:

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Abstract

The invention belongs to the field of medicine, and specifically relates to a novel thieno[3,2-d]pyrimidine derivative with a structure of general formula (I) and its application. Derivatives are represented by general formula (I), or pharmaceutically acceptable salts of compounds represented by general formula (I). wherein n and Ar are as defined in the claims specification. The pharmacological activity screening results of some compounds show that they have significant inhibitory effects on human gastric cancer cell MKN45, human lung adenocarcinoma cell A549 and human colon cancer cell HT29, and have good prospects for the development and application of anti-tumor drugs.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to a novel thieno[3,2-d]pyrimidine derivative with a structure of general formula (I) and its application. Background technique [0002] Malignant tumors are also called cancer, which is the uncontrolled growth and spread of cells. It can affect almost any part of the body. Tumors often invade surrounding tissue and can metastasize to other sites. Cancer is a leading cause of death worldwide. Cancer has become an important and major public health problem that seriously threatens human health and social and economic development. In 2015, nearly 8.8 million people died of cancer worldwide, accounting for about one-sixth of the global death toll. Lung, stomach, colon, liver and breast cancers are responsible for the majority of cancer deaths each year. The most common types of cancer differ between men and women. The number of cancer deaths worldwide will continue to increase, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D495/04A61K31/519A61P35/00
CPCC07D495/04A61P35/00
Inventor 季晓晖卢久富
Owner SHAANXI SCI TECH UNIV