Method for determining pharmacokinetics of axitinib and method for predicting therapeutic effect of axitinib based on pharmacokinetics of axitinib
A technology of pharmacokinetics and determination methods, applied in chemical property prediction, biochemical equipment and methods, microbial measurement/testing, etc., can solve problems such as inapplicability of axitinib
Pending Publication Date: 2019-12-31
YAMAGUCHI UNIV +1
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Problems solved by technology
[0008] However, the technology disclosed in Patent Document 2 is related to the epidermal growth factor receptor tyrosine kinase inhibitor drug erlotinib, and this technology is not a model for directly predicting the therapeutic effect of erlotinib, but only uses ABCB1 complex pharmacokinetic prediction, etc., so this technology cannot be applied to axitinib
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Embodiment 1
[0156] In this example, using a regression model with relevant gene polymorphism information and patient background factors as variables, a blood concentration-time curve for predicting the therapeutic effect and side effects of axitinib was established The model of the area under (AUC, one of the pharmacokinetic analysis parameters).
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In the present invention, the pharmacokinetics of axitinib are easily determined and the therapeutic effect of axitinib are predicted. A method for determining the pharmacokinetics of axitinib that includes a step for calculating predictive pharmacokinetic parameters of axitinib using specific genetic polymorphisms and background factors relating to a subject.
Description
technical field [0001] The present invention relates to a method for judging the pharmacokinetics of axitinib that can be applied to unresectable or metastatic renal cell carcinoma, and a method for predicting the therapeutic effect of axitinib based on the pharmacokinetics of axitinib. Background technique [0002] Axitinib is an oral tyrosine kinase inhibitor that selectively inhibits vascular endothelial growth factor receptor (VEGFR)-1, vascular endothelial growth factor receptor-2, and vascular endothelial growth factor receptor-3 . Incidentally, VEGFR-1, VEGFR-2, and VEGFR-3 are considered to be involved in tumor growth, cancer invasion (tumor spread), and metastasis. It is also believed that axitinib can selectively inhibit VEGFR-1, VEGFR-2, and VEGFR-3, thereby inhibiting angiogenesis and lymphangiogenesis, and inhibiting tumor proliferation and metastasis, showing anti-tumor activity. [0003] Currently, axitinib is used as a molecularly targeted drug for unresect...
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IPC IPC(8): C12Q1/6886C12M1/34G01N33/53
CPCC12M1/34G01N33/53C12Q1/6886C12Q2600/106C12Q2600/156G16B20/20G16C20/30
Inventor 松山豪泰浜本義彦藤田悠介山本義明恒富亮一大场光芳山野博文石川有希华
Owner YAMAGUCHI UNIV
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