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Application of water-soluble pearl powder to promotion of wound healing

A water-soluble pearl powder and wound healing technology, applied in the field of biomedicine, can solve the problems of being difficult to use directly, and achieve the effects of easy absorption, fast wound repair, and inhibition of scar formation

Pending Publication Date: 2020-01-03
GUANGDONG OCEAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main component of pearl powder is calcium carbonate, and it is rich in various trace elements, proteins, amino acids and other functional substances, most of which are insoluble components, which are difficult to use directly

Method used

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  • Application of water-soluble pearl powder to promotion of wound healing
  • Application of water-soluble pearl powder to promotion of wound healing
  • Application of water-soluble pearl powder to promotion of wound healing

Examples

Experimental program
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Effect test

Embodiment 1

[0055] An application of water-soluble pearl powder in promoting wound healing, characterized in that the water-soluble pearl powder has a new purpose of repairing skin wounds;

[0056] The preparation method of described water-soluble pearl powder comprises the following steps:

[0057] S1. Pretreatment: washing, drying and preliminarily crushing the pearl or nacre layer into a powder of more than 200 mesh;

[0058] S2. Acid method modification; by weight, take 80 parts of pearl powder and 20 parts of 37% lactic acid solution. After the two components are mixed, keep the temperature at 70°C and keep stirring until the pH of the mixed system reaches 5.0, and after standing still When there is no obvious precipitation of insoluble matter, stop heating and cool to room temperature;

[0059] S3. Enzymatic modification; enzymatic hydrolysis of the liquid obtained in S2, after the enzymatic hydrolysis, inactivate the enzyme at 100°C for 10 minutes, centrifuge to take the supernata...

Embodiment 2

[0082] An application of water-soluble pearl powder in promoting wound healing, characterized in that the water-soluble pearl powder has a new purpose of repairing skin wounds;

[0083] The preparation method of described water-soluble pearl powder comprises the following steps:

[0084] S1. Pretreatment: washing, drying and preliminarily crushing the pearl or nacre layer into a powder of more than 200 mesh;

[0085] S2. Acid method modification; in parts by weight, take 75 parts of pearl powder and 16 parts of 32% lactic acid solution. After the two components are mixed, keep the temperature at 55°C and keep stirring until the pH of the mixed system reaches 4.8, and after standing still When there is no obvious precipitation of insoluble matter, stop heating and cool to room temperature;

[0086] S3. Enzymatic modification; enzymatic hydrolysis of the liquid obtained in S2, after the enzymatic hydrolysis, inactivate the enzyme at 100°C for 10 minutes, centrifuge to take the ...

Embodiment 3

[0105] An application of water-soluble pearl powder in promoting wound healing, characterized in that the water-soluble pearl powder has a new purpose of repairing skin wounds;

[0106] The preparation method of described water-soluble pearl powder comprises the following steps:

[0107] S1. Pretreatment: washing, drying and preliminarily crushing the pearl or nacre layer into a powder of more than 200 mesh;

[0108] S2. Acid method modification; by weight, take 85 parts of pearl powder and 24 parts of 45% lactic acid solution. After the two components are mixed, keep the temperature at 80°C and keep stirring until the pH of the mixed system reaches 5.4, and after standing still When there is no obvious precipitation of insoluble matter, stop heating and cool to room temperature;

[0109] S3. Enzymatic modification; enzymatic hydrolysis of the liquid obtained in S2, after the enzymatic hydrolysis, inactivate the enzyme at 100°C for 10 minutes, centrifuge to take the supernatant...

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Abstract

The invention provides application of water-soluble pearl powder to promotion of wound healing. The water-soluble pearl powder has the new usage for repairing skin wound. A preparation method of the water-soluble pearl powder comprises the following steps that S1, pretreatment is conducted; S2, acid modification is conducted; and S3, enzymatic modification is conducted, specifically, liquid obtained in the S2 is subjected to enzymolysis, after enzymolysis is completed, enzyme deactivation is conducted at 100 DEG C for ten minutes, centrifuging is conducted, supernatant is taken, subjected to freeze drying and crushed till the grain size being 200 meshes or above, and the water-soluble pearl powder is obtained. The invention provides the new usage of the water-soluble pearl powder to skin wound drugs for repairing skin burns, wounds, ambustion, scalds and the like, the effect of the water-soluble pearl powder is obviously better than that of drugs in the prior art, wound repairing is quick, scars are avoided, and the wound repairing promoting effect is more obvious.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of water-soluble pearl powder in promoting wound healing. Background technique [0002] Worldwide, more than 40 million people suffer from skin trauma each year. If the damaged skin cannot be repaired in time, the wound will be easily infected and become a chronic wound, severe trauma or even life-threatening. A good remodeling effect will reduce skin scars and even achieve scarless healing. [0003] Wound healing mainly includes four periods: hemostasis and coagulation, inflammation, proliferation and tissue remodeling. After the body suffers trauma, platelets are activated and secrete related factors to promote blood coagulation into thrombus to achieve coagulation and stimulate the body to produce inflammatory reactions. During the inflammatory phase, the immune system engulfs tissue fragments and kills environmental pollutants such as inva...

Claims

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Application Information

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IPC IPC(8): A61K35/618A61K9/70A61K47/42A61K47/36A61P17/02A61L15/42A61L15/44A61L15/40
CPCA61K35/618A61K9/7007A61K47/42A61K47/36A61P17/02A61L15/425A61L15/44A61L15/40A61L2300/30A61L2300/412A61L2300/404
Inventor 林海生章超桦谢绍河林展新秦小明苏伟明
Owner GUANGDONG OCEAN UNIVERSITY
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